GB1518683A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1518683A GB1518683A GB28246/75A GB2824675A GB1518683A GB 1518683 A GB1518683 A GB 1518683A GB 28246/75 A GB28246/75 A GB 28246/75A GB 2824675 A GB2824675 A GB 2824675A GB 1518683 A GB1518683 A GB 1518683A
- Authority
- GB
- United Kingdom
- Prior art keywords
- july
- skin permeation
- alkaloid
- ergot
- dissolved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002280 amphoteric surfactant Substances 0.000 abstract 1
- 239000003945 anionic surfactant Substances 0.000 abstract 1
- 229960003133 ergot alkaloid Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229930015720 peptide alkaloid Natural products 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1518683 Skin permeation compositions SANDOZ Ltd 4 July 1975 [5 July 1974] 28246/75 Heading A5B A skin permeation preparation comprises (a) at least one active ingredient at least partly dissolved in a carrier comprising (b) a C 11 -C 24 aliphatic alcohol which is liquid at 25C, and (c) an amphoteric or anionic surfactant, the concentration of (c) being at least 5% by wt. in the composition and such that it would give a pH of 4 to 8 if dissolved in water at the same concentration. The active agent (a) may be a quinazoline, an ergot alkaloid, an hydrogenated derivative of an ergot peptide alkaloid or 4-(1-methyl-4-piperidylidene)-4H-benzo [4, G] cyclohepta [1, 2-b]- thiophen-10 (9H)-one.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH931274 | 1974-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1518683A true GB1518683A (en) | 1978-07-19 |
Family
ID=4350618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28246/75A Expired GB1518683A (en) | 1974-07-05 | 1975-07-04 | Pharmaceutical compositions |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5132724A (en) |
| AU (1) | AU8280175A (en) |
| BE (1) | BE831042A (en) |
| DE (1) | DE2528516A1 (en) |
| ES (1) | ES439113A1 (en) |
| FR (1) | FR2276832A1 (en) |
| GB (1) | GB1518683A (en) |
| HU (1) | HU170215B (en) |
| IL (1) | IL47634A (en) |
| NL (1) | NL7507798A (en) |
| NZ (1) | NZ178011A (en) |
| SE (1) | SE7507414L (en) |
| YU (1) | YU170475A (en) |
| ZA (1) | ZA754304B (en) |
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
| US4752612A (en) * | 1983-07-01 | 1988-06-21 | Nitto Electrical Industrial Co., Ltd. | Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| GB2230444A (en) * | 1989-04-19 | 1990-10-24 | Ritchie Swanson John | Topical therapeutic compositions containing betaine surfactant |
| US5059427A (en) * | 1987-05-15 | 1991-10-22 | Sansho Co., Ltd. | Pharmaceutical preparation for percutaneous administration containing eperisone or tolperisone or salt thereof |
| US5128376A (en) * | 1983-07-01 | 1992-07-07 | Nitto Denko Corporation | Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator |
| US5219877A (en) * | 1989-09-25 | 1993-06-15 | Bristol-Myers Squibb Company | Lauryl alcohol as skin penetration enhancer for topical imidazole agents |
| US5223261A (en) * | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US5652228A (en) * | 1993-11-12 | 1997-07-29 | The Procter & Gamble Company | Topical desquamation compositions |
| US5681852A (en) * | 1993-11-12 | 1997-10-28 | The Procter & Gamble Company | Desquamation compositions |
| US5807820A (en) * | 1988-05-13 | 1998-09-15 | Novartis Ag | Cyclosporin compositions for topical application |
| US5821237A (en) * | 1995-06-07 | 1998-10-13 | The Procter & Gamble Company | Compositions for visually improving skin |
| US6005135A (en) * | 1996-03-21 | 1999-12-21 | Exxon Chemical Patents Inc. | Water-borne polymeric vehicle for coating compositions containing an amine or ammonium salt of phenolic ester alcohols |
| EP1011610A4 (en) * | 1997-08-15 | 2004-08-18 | Scandinavian American Imp Exp | Skin care compositions and use |
| EP2223703A4 (en) * | 2007-11-22 | 2011-01-19 | Medrx Co Ltd | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
| EP2570116A1 (en) * | 2011-09-13 | 2013-03-20 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| EP2570115A1 (en) * | 2011-09-13 | 2013-03-20 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| US9526763B2 (en) | 2005-02-03 | 2016-12-27 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
| US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| US9572889B2 (en) | 2008-02-13 | 2017-02-21 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| US9682127B2 (en) | 2005-02-03 | 2017-06-20 | Intarcia Therapeutics, Inc. | Osmotic delivery device comprising an insulinotropic peptide and uses thereof |
| US9724293B2 (en) | 2003-11-17 | 2017-08-08 | Intarcia Therapeutics, Inc. | Methods of manufacturing viscous liquid pharmaceutical formulations |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
| US10231923B2 (en) | 2009-09-28 | 2019-03-19 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| US10527170B2 (en) | 2006-08-09 | 2020-01-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
| US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54163810A (en) * | 1978-06-14 | 1979-12-26 | Mundipharma Ag | Gel composition for local coating |
| JPS56159310A (en) * | 1980-05-14 | 1981-12-08 | Showa Denko Kk | Preparation of monofilament having high strength and knot strength |
| FR2483235A1 (en) * | 1980-05-28 | 1981-12-04 | Fabre Sa Pierre | TOPICAL COMPOSITIONS CONTAINING RYE AND VINCA ROSEA ERGOT ALKALOIDS FOR THE TREATMENT OF HYPERSEBORRHOES |
| JPS59216825A (en) * | 1983-05-23 | 1984-12-06 | Takeda Chem Ind Ltd | External drug for transcutaneous absorption |
| US4590190A (en) * | 1983-07-01 | 1986-05-20 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| JPS6013720A (en) * | 1983-07-01 | 1985-01-24 | Nitto Electric Ind Co Ltd | Percutaneous administration of physiological activator using adjuvant, solvent and diol modulator |
| JPH0735331B2 (en) * | 1986-01-16 | 1995-04-19 | 久光製薬株式会社 | External gel formulation |
| JPH0735332B2 (en) * | 1986-02-25 | 1995-04-19 | 久光製薬株式会社 | Cream formulation for external use |
| JPH0759519B2 (en) * | 1987-02-23 | 1995-06-28 | 株式会社資生堂 | Transdermal absorption enhancer and external preparation for skin containing the same |
| US4746515A (en) * | 1987-02-26 | 1988-05-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolaurate |
| DE3710216A1 (en) * | 1987-03-27 | 1988-10-06 | Rentschler Arzneimittel | USE OF DIHYDROERGOTAMINE AND ITS SALTS FOR LOCAL TREATMENT OF TROPHIC DISORDERS |
| US5397771A (en) * | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
| ATE164080T1 (en) * | 1990-05-10 | 1998-04-15 | Bechgaard Int Res | PHARMACEUTICAL PREPARATION CONTAINING N-GLYCOFUROLES AND N-ETHYLENE GLYCOLS |
| IL98747A0 (en) * | 1991-07-05 | 1992-07-15 | Yissum Res Dev Co | Ophthalmic compositions |
| PT1666026E (en) † | 1999-02-08 | 2012-03-15 | Intarcia Therapeutics Inc | Non-aqueous single phase biocompatible viscous vehicles and methods for preparing the same |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| JP2012020991A (en) | 2010-06-16 | 2012-02-02 | Takasago Internatl Corp | Transdermal absorption promoter, and external skin formulation thereof |
| EP3395369A1 (en) | 2014-10-30 | 2018-10-31 | Asahi Kasei Kabushiki Kaisha | Transdermal absorption enhancer and transdermal absorption enhancement aid |
-
1975
- 1975-06-26 DE DE19752528516 patent/DE2528516A1/en active Pending
- 1975-06-27 SE SE7507414A patent/SE7507414L/en unknown
- 1975-07-01 NL NL7507798A patent/NL7507798A/en unknown
- 1975-07-02 YU YU01704/75A patent/YU170475A/en unknown
- 1975-07-03 NZ NZ178011A patent/NZ178011A/en unknown
- 1975-07-03 ES ES439113A patent/ES439113A1/en not_active Expired
- 1975-07-03 IL IL47634A patent/IL47634A/en unknown
- 1975-07-03 HU HUSA2816A patent/HU170215B/hu unknown
- 1975-07-03 FR FR7520946A patent/FR2276832A1/en active Granted
- 1975-07-04 GB GB28246/75A patent/GB1518683A/en not_active Expired
- 1975-07-04 ZA ZA754304A patent/ZA754304B/en unknown
- 1975-07-04 JP JP50082022A patent/JPS5132724A/ja active Pending
- 1975-07-04 BE BE158022A patent/BE831042A/en unknown
- 1975-07-07 AU AU82801/75A patent/AU8280175A/en not_active Expired
Cited By (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752612A (en) * | 1983-07-01 | 1988-06-21 | Nitto Electrical Industrial Co., Ltd. | Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| US5128376A (en) * | 1983-07-01 | 1992-07-07 | Nitto Denko Corporation | Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator |
| US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
| US5059427A (en) * | 1987-05-15 | 1991-10-22 | Sansho Co., Ltd. | Pharmaceutical preparation for percutaneous administration containing eperisone or tolperisone or salt thereof |
| US5073375A (en) * | 1987-05-15 | 1991-12-17 | Sansho Co., Ltd. | Pharmaceutical preparation for percutaneous administration containing eperisone or tolperisone or salt thereof |
| US5223261A (en) * | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US5807820A (en) * | 1988-05-13 | 1998-09-15 | Novartis Ag | Cyclosporin compositions for topical application |
| GB2230444B (en) * | 1989-04-19 | 1993-12-08 | Ritchie Swanson John | Therapeutic compositions. |
| GB2230444A (en) * | 1989-04-19 | 1990-10-24 | Ritchie Swanson John | Topical therapeutic compositions containing betaine surfactant |
| US5219877A (en) * | 1989-09-25 | 1993-06-15 | Bristol-Myers Squibb Company | Lauryl alcohol as skin penetration enhancer for topical imidazole agents |
| US5652228A (en) * | 1993-11-12 | 1997-07-29 | The Procter & Gamble Company | Topical desquamation compositions |
| US5681852A (en) * | 1993-11-12 | 1997-10-28 | The Procter & Gamble Company | Desquamation compositions |
| US5849728A (en) * | 1993-11-12 | 1998-12-15 | The Procter & Gamble Company | Desquamation compositions |
| US5821237A (en) * | 1995-06-07 | 1998-10-13 | The Procter & Gamble Company | Compositions for visually improving skin |
| US6005135A (en) * | 1996-03-21 | 1999-12-21 | Exxon Chemical Patents Inc. | Water-borne polymeric vehicle for coating compositions containing an amine or ammonium salt of phenolic ester alcohols |
| EP1011610A4 (en) * | 1997-08-15 | 2004-08-18 | Scandinavian American Imp Exp | Skin care compositions and use |
| US9724293B2 (en) | 2003-11-17 | 2017-08-08 | Intarcia Therapeutics, Inc. | Methods of manufacturing viscous liquid pharmaceutical formulations |
| US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| US10363287B2 (en) | 2005-02-03 | 2019-07-30 | Intarcia Therapeutics, Inc. | Method of manufacturing an osmotic delivery device |
| US9526763B2 (en) | 2005-02-03 | 2016-12-27 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| US9682127B2 (en) | 2005-02-03 | 2017-06-20 | Intarcia Therapeutics, Inc. | Osmotic delivery device comprising an insulinotropic peptide and uses thereof |
| US10527170B2 (en) | 2006-08-09 | 2020-01-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
| AU2008327436B2 (en) * | 2007-11-22 | 2013-09-05 | Medrx Co., Ltd. | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
| CN101909651B (en) * | 2007-11-22 | 2013-11-06 | 美德阿利克斯株式会社 | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
| US8623387B2 (en) | 2007-11-22 | 2014-01-07 | Medrx Co., Ltd. | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
| CN103239721B (en) * | 2007-11-22 | 2016-03-16 | 美德阿利克斯株式会社 | Comprise ion type liquid based on fatty acid as the external preparation composition of active component |
| EP2223703A4 (en) * | 2007-11-22 | 2011-01-19 | Medrx Co Ltd | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
| US9572889B2 (en) | 2008-02-13 | 2017-02-21 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| US10441528B2 (en) | 2008-02-13 | 2019-10-15 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| US10231923B2 (en) | 2009-09-28 | 2019-03-19 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US10869830B2 (en) | 2009-09-28 | 2020-12-22 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US12042557B2 (en) | 2009-09-28 | 2024-07-23 | I2O Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
| US9707187B2 (en) | 2011-09-13 | 2017-07-18 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| US9707189B2 (en) | 2011-09-13 | 2017-07-18 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| EP2570116A1 (en) * | 2011-09-13 | 2013-03-20 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| EP2570115A1 (en) * | 2011-09-13 | 2013-03-20 | Nitto Denko Corporation | Composition for enhancing transdermal absorption of a drug and patch preparation |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10583080B2 (en) | 2014-09-30 | 2020-03-10 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| US11840559B2 (en) | 2016-05-16 | 2023-12-12 | I2O Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| US11214607B2 (en) | 2016-05-16 | 2022-01-04 | Intarcia Therapeutics Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD912249S1 (en) | 2016-06-02 | 2021-03-02 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD962433S1 (en) | 2016-06-02 | 2022-08-30 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
| US11654183B2 (en) | 2017-01-03 | 2023-05-23 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of exenatide and co-administration of a drug |
Also Published As
| Publication number | Publication date |
|---|---|
| ES439113A1 (en) | 1977-10-16 |
| DE2528516A1 (en) | 1976-01-22 |
| AU8280175A (en) | 1977-01-13 |
| NZ178011A (en) | 1978-07-28 |
| HU170215B (en) | 1977-04-28 |
| NL7507798A (en) | 1976-01-07 |
| SE7507414L (en) | 1976-01-07 |
| BE831042A (en) | 1976-01-05 |
| FR2276832A1 (en) | 1976-01-30 |
| IL47634A (en) | 1978-07-31 |
| ZA754304B (en) | 1977-02-23 |
| FR2276832B1 (en) | 1978-10-06 |
| IL47634A0 (en) | 1975-10-15 |
| JPS5132724A (en) | 1976-03-19 |
| YU170475A (en) | 1984-02-29 |
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