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GB1516095A - 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series - Google Patents

17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Info

Publication number
GB1516095A
GB1516095A GB33786/74A GB3378674A GB1516095A GB 1516095 A GB1516095 A GB 1516095A GB 33786/74 A GB33786/74 A GB 33786/74A GB 3378674 A GB3378674 A GB 3378674A GB 1516095 A GB1516095 A GB 1516095A
Authority
GB
United Kingdom
Prior art keywords
diesters
17alpha
steroids
dihydroxy
pregnane series
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33786/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB33786/74A priority Critical patent/GB1516095A/en
Priority to NL7509075A priority patent/NL7509075A/en
Priority to IE1708/75A priority patent/IE42124B1/en
Priority to JP50092137A priority patent/JPS51125059A/en
Priority to SE7508654A priority patent/SE7508654L/en
Priority to DE19752534051 priority patent/DE2534051A1/en
Priority to CH996575A priority patent/CH615442A5/en
Priority to ZA00754907A priority patent/ZA754907B/en
Priority to ES439852A priority patent/ES439852A1/en
Priority to CA232,579A priority patent/CA1058610A/en
Priority to DK346975AA priority patent/DK139303B/en
Priority to FR7523787A priority patent/FR2280383A1/en
Priority to BE158780A priority patent/BE831931A/en
Priority to AU83531/75A priority patent/AU492456B2/en
Publication of GB1516095A publication Critical patent/GB1516095A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

17 alpha ,21-Diesters of 17 alpha ,21-dihydroxysteroids of the pregnane series corresponding to the formula I in which the symbols X, Y, R<1> and R<2> have the meaning stated in Claim 1 are prepared by reacting a compound which has the group -CH2OCO(CH2)nZ in position 21, where Z is a substituent which can easily be replaced, with a compound of the formula H-NR<3>R<4>. The compounds are distinguished not only by a good topical antiinflammatory effect but also by an excellent systemic antiinflammatory effect. <IMAGE>
GB33786/74A 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series Expired GB1516095A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB33786/74A GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series
NL7509075A NL7509075A (en) 1974-07-31 1975-07-30 PROCESS FOR PREPARATION OF NEW 17 (ALPHA), 21 DIESTERS OF 17 (ALPHA), 21 DIHYDROXYSTEROIDS FROM THE PREGNAN SERIES.
IE1708/75A IE42124B1 (en) 1974-07-31 1975-07-30 17,21-diesters of 17,21-dihydroxy steroids of the pregnaneseries
JP50092137A JPS51125059A (en) 1974-07-31 1975-07-30 Production of novel steroid
SE7508654A SE7508654L (en) 1974-07-31 1975-07-30 PROCEDURE FOR THE MANUFACTURE OF STEROIDS
DE19752534051 DE2534051A1 (en) 1974-07-31 1975-07-30 17 ALPHA, 21-DIESTER OF 17 ALPHA, 21-DIHYDROXYSTEROID DERIVATIVES, METHODS FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS WHICH CONTAIN THEM
CH996575A CH615442A5 (en) 1974-07-31 1975-07-30 Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series
ZA00754907A ZA754907B (en) 1974-07-31 1975-07-30 17,21-diesters of 17,21-dihydroxy steroids of the pregnane series containing a basic 21-ester grouping
ES439852A ES439852A1 (en) 1974-07-31 1975-07-30 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series
CA232,579A CA1058610A (en) 1974-07-31 1975-07-30 17a, 21-diesters of the pregnane series
DK346975AA DK139303B (en) 1974-07-31 1975-07-30 Analogous process for the preparation of 11-oxygenated 17alpha, 21-diacyloxy-9alpha-halogen-16beta-methylpregn-4-ene-3,20-diones or acid addition salts thereof.
FR7523787A FR2280383A1 (en) 1974-07-31 1975-07-30 NEW 17A, 21-DIESTERS OF 17A, 21-DIHYDROXY STEROIDS, THEIR PREPARATION PROCESS, AND THEIR APPLICATION
BE158780A BE831931A (en) 1974-07-31 1975-07-30 NEW 17ALPHA, 21-DIESTERS OF 17ALPHA, 21-DIHYDROXY STEROIDS AND THEIR PREPARATION
AU83531/75A AU492456B2 (en) 1974-07-31 1975-07-30 17,21-diesters of 17, 21-dihydroxy-steroids of the pregnane series

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33786/74A GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Publications (1)

Publication Number Publication Date
GB1516095A true GB1516095A (en) 1978-06-28

Family

ID=10357423

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33786/74A Expired GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Country Status (13)

Country Link
JP (1) JPS51125059A (en)
BE (1) BE831931A (en)
CA (1) CA1058610A (en)
CH (1) CH615442A5 (en)
DE (1) DE2534051A1 (en)
DK (1) DK139303B (en)
ES (1) ES439852A1 (en)
FR (1) FR2280383A1 (en)
GB (1) GB1516095A (en)
IE (1) IE42124B1 (en)
NL (1) NL7509075A (en)
SE (1) SE7508654L (en)
ZA (1) ZA754907B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835724B2 (en) 1993-10-05 2004-12-28 Aventis Pharma Deutschland Gmbh Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
FR2600653B1 (en) * 1986-06-24 1988-12-16 Pasteur Strasbourg Universite COMPOUNDS FOR ASSOCIATIVE SYNTHESIS OF SULFUR OR NON-SULFUR AMINO ACIDS WITH D-4 PREGNENE 3,20-DIONE DERIVATIVES OR WITH D-1,4 PREGNADIENE 3,20-DIONE DERIVATIVES WITH GLUCOCORTICOID AND ANTI-INFLAMMATORY PROPERTIES, METHODS OBTAINED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. PHARMACOLOGICAL PROPERTIES AND APPLICATIONS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044212B (en) * 1971-03-17 1980-03-20 Sigma Tau Ind Farmaceuti ESTERS OF BESAMETAZONE AND BETAMETAZONE
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835724B2 (en) 1993-10-05 2004-12-28 Aventis Pharma Deutschland Gmbh Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds

Also Published As

Publication number Publication date
DE2534051A1 (en) 1976-02-19
CH615442A5 (en) 1980-01-31
CA1058610A (en) 1979-07-17
ES439852A1 (en) 1977-03-01
IE42124B1 (en) 1980-06-04
DK139303C (en) 1979-08-06
BE831931A (en) 1976-01-30
DK139303B (en) 1979-01-29
FR2280383B1 (en) 1978-10-06
NL7509075A (en) 1976-02-03
DK346975A (en) 1976-02-01
FR2280383A1 (en) 1976-02-27
IE42124L (en) 1976-01-31
SE7508654L (en) 1976-02-02
ZA754907B (en) 1976-07-28
JPS51125059A (en) 1976-11-01
AU8353175A (en) 1977-02-03

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee