GB1511571A - Lactam compounds and conjugates - Google Patents
Lactam compounds and conjugatesInfo
- Publication number
- GB1511571A GB1511571A GB1348875A GB1348875A GB1511571A GB 1511571 A GB1511571 A GB 1511571A GB 1348875 A GB1348875 A GB 1348875A GB 1348875 A GB1348875 A GB 1348875A GB 1511571 A GB1511571 A GB 1511571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- yield
- acid
- sodium
- reacted
- diphenylhydantoin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Lactam compounds Chemical class 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 9
- JBSMSVZHETUQQA-UHFFFAOYSA-N 5,5-diphenylimidazolidine-2,4-dione;sodium Chemical compound [Na].N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 JBSMSVZHETUQQA-UHFFFAOYSA-N 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 239000012312 sodium hydride Substances 0.000 abstract 3
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 3
- QCNABQCBYVFCEX-UHFFFAOYSA-N 2-[4-(2,5-dioxo-4-phenylimidazolidin-4-yl)phenoxy]acetic acid Chemical compound C1=CC(OCC(=O)O)=CC=C1C1(C=2C=CC=CC=2)C(=O)NC(=O)N1 QCNABQCBYVFCEX-UHFFFAOYSA-N 0.000 abstract 2
- SLFDVIROMKYTAA-UHFFFAOYSA-N 3-(3-methyl-2,5-dioxopyrrolidin-3-yl)propanoic acid Chemical compound C(=O)(O)CCC1(C(=O)NC(C1)=O)C SLFDVIROMKYTAA-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 abstract 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N 1,1-Diethoxyethane Chemical compound CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- USGBLEMQARVRDC-UHFFFAOYSA-N 1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-amine Chemical compound CC1(C)CC(N)C(C)(C)N1O USGBLEMQARVRDC-UHFFFAOYSA-N 0.000 abstract 1
- GQFCLJZQECVTDO-UHFFFAOYSA-N 2-(2-chloroethoxy)acetonitrile Chemical compound ClCCOCC#N GQFCLJZQECVTDO-UHFFFAOYSA-N 0.000 abstract 1
- RVBUGGBMJDPOST-UHFFFAOYSA-N 2-thiobarbituric acid Chemical compound O=C1CC(=O)NC(=S)N1 RVBUGGBMJDPOST-UHFFFAOYSA-N 0.000 abstract 1
- ISZSECZOIFIWLV-UHFFFAOYSA-N 3-methyl-2-pentan-3-ylhex-2-enenitrile Chemical compound C(C)C(C(=C(CCC)C)C#N)CC ISZSECZOIFIWLV-UHFFFAOYSA-N 0.000 abstract 1
- WCMVZDBWMRWITA-UHFFFAOYSA-N 4-(2-carboxypropyl)-2,5-dioxopyrrolidine-3-carboxylic acid Chemical compound CC(CC1C(=O)NC(C1C(=O)O)=O)C(=O)O WCMVZDBWMRWITA-UHFFFAOYSA-N 0.000 abstract 1
- XEEDURHPFVXALT-UHFFFAOYSA-N 4-hydroxyphenytoin Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC=CC=2)C(=O)NC(=O)N1 XEEDURHPFVXALT-UHFFFAOYSA-N 0.000 abstract 1
- RIMXEJYJXDBLIE-UHFFFAOYSA-N 6-bromohex-1-ene Chemical compound BrCCCCC=C RIMXEJYJXDBLIE-UHFFFAOYSA-N 0.000 abstract 1
- RENMDAKOXSCIGH-UHFFFAOYSA-N Chloroacetonitrile Chemical compound ClCC#N RENMDAKOXSCIGH-UHFFFAOYSA-N 0.000 abstract 1
- ICMAFTSLXCXHRK-UHFFFAOYSA-N Ethyl pentanoate Chemical compound CCCCC(=O)OCC ICMAFTSLXCXHRK-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000047875 Pica hudsonia Species 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 abstract 1
- 229940106681 chloroacetic acid Drugs 0.000 abstract 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- ARFLASKVLJTEJD-UHFFFAOYSA-N ethyl 2-bromopropanoate Chemical compound CCOC(=O)C(C)Br ARFLASKVLJTEJD-UHFFFAOYSA-N 0.000 abstract 1
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 abstract 1
- PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 abstract 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 abstract 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000005949 ozonolysis reaction Methods 0.000 abstract 1
- 229960002036 phenytoin Drugs 0.000 abstract 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 abstract 1
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 abstract 1
- 229960002393 primidone Drugs 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9446—Antibacterials
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pyrrole Compounds (AREA)
Abstract
1511571 Lactam derivatives and intermediates therefor; spin-label compounds SYNTEX ENERGY RESEARCH Ine and VARIAN ENERGY [trading as SYVA CO] 2 April 1975 [28 June 1974] 13488/75 Heading C2C [Also in Divisions C3 and G1] (1.1) The reaction of chloroacetic acid/sodium bicarbonate and sodium diphenylhydantoin yields; 3- (N - carboxymethyl)diphenylhydantoin (1.2) The reaction of sodium diphenylhydantoin and chloroacetonitrile yields; 3-(N-cyanomethyl)- diphenylhydantoin which is hydrolysed with sodium ethoxide/ethanol to; 3 - (N - carboxymethyl)diphenylhydantoin (1.3) Sodium diphenylhydantoin is reacted with ethyl 2-bromopropionate to yield; 2-(N-diphenylhydantoinyl)- propionic acid, ethyl ester which is hydrolysed with aqueous sodium hydroxide to; 2-(N-diphenylhydantoinyl)propionic acid (1.4) Sodium diphenylhydantoin is reacted with ethyl n-5- bromopentanoate to yield; 5-(N<SP>31</SP>-diphenylhydantoinyl)pentanoic acid, ethyl ester which, on hydrolysis with aqueous hydroxide, yields 5 - (N<SP>31</SP> - diphenylhydantoinyl)pentanoic acid (1.5) Sodium diphenylhydantoin is reacted with 2 - chloroethoxyacetonitrile to yield; (2 - (N - diphenylhydantoinyl)ethoxy)acetonitrile which is hydrolysed with sodium hydroxide/ ethanol to; (2 - (N - diphenylhydantoinyl) - ethoxy)acetic acid. (1.6) 5-(p-hydroxyphenyl)- 5 - phenylhydantoin is reacted with sodium chloroacetate to yield; 5-(p-carboxymethoxyphenyl) - 5 - phenylhydantoin. (1.7) Primidone, reduced with sodium hydride, is reacted with ethyl bromoacetate to yield; 2-deoxo-1-barbiturylacetic acid, ethy elster which is hydrolysed with sodium hydroxide to yield; 2-deoxo-1- barbiturylacetic acid. (1.8) Phenyldiethyl malonate, reduced with sodium hydride and the product reacted with 6-bromo-1-hexene to yield; diethyl - 2 - phenyl - 2 - (5<SP>1 </SP>- hexenyl - 1<SP>1</SP>)- malonate which, on ozonolysis, yields; diethyl 2 - phenyl - 2 - (5<SP>1</SP>- pentanal - 1<SP>1</SP> - yl) - malonate which is treated with p-toluene sulphonic acid to yield; diethyl 2-phenyl-(5<SP>1</SP>-pentanal-1<SP>1</SP>-yl)- malonate diethyl acetal which is treated' with thiobarbituric acid, and the product hydrogenated over Raney nickel to yield; 2-deoxo-5- phenyl - 5 - (5<SP>1</SP> - pentanal - 1<SP>1</SP> - yl) - thiobarbituric acid diethyl acetal which is treated with acetic acid to yield; 2-deoxo-5-(5<SP>1</SP>-pentanal-1<SP>1</SP>-yl)barbituric acid which is oxidized with chromic acid/sulphuric acid to; 5-(2<SP>1</SP>-deoxo-5<SP>1</SP>-phenylbarbituryl)pentanoic acid. (1.9) Zerantin, reduced with sodium hydride, is reacted with iodoacetic acid to yield; 1-carboxymethylzarontin. (1.10) Ethyl cyanoacetate and ethyl levalinate are reacted to yield; diethyl 2-cyano-3- methylhex - 2 - en - 1,6 - dionate which is treated with potassium cyanide to yield 2-methyl-2- (21 - cyanomethoxyethyl) - 3 - cyanomethoxysuccinimide; which is treated with sodium hydroxide and phosphonic acid to yield 2- methyl - 2 - (2<SP>1</SP>- carbomethoxyethyl) - 3 - carbomethoxy succinimide which is treated with sodium hydroxide to yield 2-methyl-2-carboxyethyl-3- carboxysuccinimide which is refluxed with acetic acid to yield; 2-carboxyethyl-2-methylsuccinimide. Spin-label compounds were obtained by the reaction of, in triethylamine, 2,2,5,5-tetramethyl - 3 - amino - 1 - oxylpyrrolidine and (4.1) methyl (N<SP>3</SP>-diphenyl hydantoinyl)acetamidate; (4.2) 5-(p-carboxymethoxy phenyl)-5- phenylhydantoin; (4.3) 2-carboxyethyl-2-methylsuccinimide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48402674A | 1974-06-28 | 1974-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1511571A true GB1511571A (en) | 1978-05-24 |
Family
ID=23922433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1348875A Expired GB1511571A (en) | 1974-06-28 | 1975-04-02 | Lactam compounds and conjugates |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS511632A (en) |
| CA (1) | CA1037475A (en) |
| DE (1) | DE2521523A1 (en) |
| FR (1) | FR2276317A1 (en) |
| GB (1) | GB1511571A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0095665A1 (en) * | 1982-06-01 | 1983-12-07 | Miles Laboratories, Inc. | Labelled conjugates of ethosuximide, ethosuximide immunogens, antibodies thereto, immunoassay method employing the antibodies and reagent means, test kit and test device for the immunoassay method |
| RU2794719C1 (en) * | 2022-05-18 | 2023-04-24 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | 2-(2,5-dioxo-4,4-diarylymidazolidin-1-yl)carboxy acids, their salts and methods for their production |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069105A (en) * | 1977-03-03 | 1978-01-17 | Syva Company | Lidocaine antigens and antibodies |
| US4156081A (en) * | 1977-04-15 | 1979-05-22 | Syva Company | Theophylline antigens and antibodies |
| EP0199963B1 (en) * | 1985-04-01 | 1991-10-23 | Abbott Laboratories | Ethosuximide assay tracers, immunogens and antibodies |
| DE3924705A1 (en) * | 1989-07-26 | 1991-01-31 | Boehringer Mannheim Gmbh | HETEROBIFUNCTIONAL CONNECTIONS |
| CN101863834B (en) * | 2010-06-29 | 2012-10-10 | 渤海大学 | Preparation method of S-carboxymethyl-5,5-diphenyl-2-thiohydantoin |
| KR102267919B1 (en) | 2018-06-28 | 2021-06-23 | 주식회사 고영테크놀러지 | Method and electronic apparatus for determining cause of mounting failure for component mounted on board |
| US11428644B2 (en) | 2018-11-27 | 2022-08-30 | Koh Young Technology Inc. | Method and electronic apparatus for displaying inspection result of board |
| CN115372501B (en) * | 2022-07-27 | 2024-03-26 | 广州科曼生物科技有限公司 | Control extract of fritillaria thunbergii or fritillaria hubei, preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
-
1975
- 1975-04-02 GB GB1348875A patent/GB1511571A/en not_active Expired
- 1975-04-23 FR FR7512665A patent/FR2276317A1/en active Granted
- 1975-04-30 CA CA225,944A patent/CA1037475A/en not_active Expired
- 1975-05-14 DE DE19752521523 patent/DE2521523A1/en not_active Ceased
- 1975-05-22 JP JP6142475A patent/JPS511632A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0095665A1 (en) * | 1982-06-01 | 1983-12-07 | Miles Laboratories, Inc. | Labelled conjugates of ethosuximide, ethosuximide immunogens, antibodies thereto, immunoassay method employing the antibodies and reagent means, test kit and test device for the immunoassay method |
| RU2794719C1 (en) * | 2022-05-18 | 2023-04-24 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | 2-(2,5-dioxo-4,4-diarylymidazolidin-1-yl)carboxy acids, their salts and methods for their production |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2521523A1 (en) | 1976-01-15 |
| JPS638427B2 (en) | 1988-02-23 |
| JPS511632A (en) | 1976-01-08 |
| CA1037475A (en) | 1978-08-29 |
| FR2276317A1 (en) | 1976-01-23 |
| FR2276317B1 (en) | 1979-04-27 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950401 |