GB1503116A - Sustained release drug delivery devices - Google Patents
Sustained release drug delivery devicesInfo
- Publication number
- GB1503116A GB1503116A GB2809376A GB2809376A GB1503116A GB 1503116 A GB1503116 A GB 1503116A GB 2809376 A GB2809376 A GB 2809376A GB 2809376 A GB2809376 A GB 2809376A GB 1503116 A GB1503116 A GB 1503116A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pharmaceutical
- polymer
- environment
- release
- soluble substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000012377 drug delivery Methods 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 6
- 239000000126 substance Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 238000011065 in-situ storage Methods 0.000 abstract 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The device for delayed pharmaceutical release is used in an aqueous environment in the human or animal body. It essentially releases the pharmaceutical by diffusion. It displays an integral solid structure of such a shape and size that it can be introduced into the environment in which it is to be used and can be held there. It consists of a mixture which contains a non-ionic pharmaceutical, a polymer and, in addition, 0.1 to 15% by weight of a soluble substance with osmotic activity. The pharmaceutical has a solubility in water of from 200 to 10,000 ppm. The polymer is permeable to water and to the pharmaceutical, is insoluble in the aqueous environment at least for the duration of the pharmaceutical release and is impermeable to the soluble substance. The soluble substance is in the form of single depots which have a number average diameter of 1 to 250 mu m which are dispersed in the polymer so that they are surrounded essentially singly by a polymer layer. When the device is introduced into the aqueous environment, the depots absorb water and rupture the surrounding polymer layers. This results in a network of mutually connected pores inside the device. There is thus an in situ enlargement of the surface area on which the pharmaceutical can be released from the polymer to the environment. This in situ enlargement of the surface area increases the rate of release of the pharmaceutical from the device.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59979575A | 1975-07-28 | 1975-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1503116A true GB1503116A (en) | 1978-03-08 |
Family
ID=24401120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2809376A Expired GB1503116A (en) | 1975-07-28 | 1976-07-06 | Sustained release drug delivery devices |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5215810A (en) |
| CA (1) | CA1083041A (en) |
| CH (1) | CH623232A5 (en) |
| DE (1) | DE2633987A1 (en) |
| FR (1) | FR2319380A1 (en) |
| GB (1) | GB1503116A (en) |
| IT (1) | IT1069521B (en) |
| SE (1) | SE7608161L (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080330A3 (en) * | 1981-11-18 | 1983-07-13 | Standard Telephones And Cables Public Limited Company | Composite materials |
| WO1997037640A3 (en) * | 1996-04-05 | 1997-11-13 | Alza Corp | Uniform drug delivery therapy |
| US6096339A (en) * | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2048710B (en) * | 1979-05-07 | 1983-03-09 | Alza Corp | Osmotically driven fluid dispenser |
| JPS60139222U (en) * | 1984-02-28 | 1985-09-14 | 株式会社東芝 | foldable recorder |
| DE19537090A1 (en) * | 1995-10-05 | 1997-04-10 | Lohmann Therapie Syst Lts | Osmotic device for the continuous release of active substances into the fluids of the gastrointestinal tract |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892842A (en) * | 1971-09-01 | 1975-07-01 | Alza Corp | Intrauterine contraceptive device for releasing steroid having double bond functionality |
| GB1425550A (en) * | 1973-04-25 | 1976-02-18 | Alza Corp | Device for releasing active agent and process for producing the same |
-
1976
- 1976-07-06 GB GB2809376A patent/GB1503116A/en not_active Expired
- 1976-07-16 SE SE7608161A patent/SE7608161L/en not_active Application Discontinuation
- 1976-07-20 CA CA257,322A patent/CA1083041A/en not_active Expired
- 1976-07-27 IT IT6887676A patent/IT1069521B/en active
- 1976-07-27 FR FR7622829A patent/FR2319380A1/en active Granted
- 1976-07-27 JP JP8960076A patent/JPS5215810A/en active Pending
- 1976-07-28 CH CH967576A patent/CH623232A5/en not_active IP Right Cessation
- 1976-07-28 DE DE19762633987 patent/DE2633987A1/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080330A3 (en) * | 1981-11-18 | 1983-07-13 | Standard Telephones And Cables Public Limited Company | Composite materials |
| WO1997037640A3 (en) * | 1996-04-05 | 1997-11-13 | Alza Corp | Uniform drug delivery therapy |
| US6096339A (en) * | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2319380B1 (en) | 1978-11-17 |
| CH623232A5 (en) | 1981-05-29 |
| JPS5215810A (en) | 1977-02-05 |
| SE7608161L (en) | 1977-01-29 |
| FR2319380A1 (en) | 1977-02-25 |
| CA1083041A (en) | 1980-08-05 |
| IT1069521B (en) | 1985-03-25 |
| DE2633987A1 (en) | 1977-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |