GB1578862A - 6-hydroxy-8-oestradiols - Google Patents
6-hydroxy-8-oestradiols Download PDFInfo
- Publication number
- GB1578862A GB1578862A GB1061877A GB1061877A GB1578862A GB 1578862 A GB1578862 A GB 1578862A GB 1061877 A GB1061877 A GB 1061877A GB 1061877 A GB1061877 A GB 1061877A GB 1578862 A GB1578862 A GB 1578862A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- ethynyl
- oestra
- triene
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 8
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- 241000222290 Cladosporium Species 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 17
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- 244000005700 microbiome Species 0.000 description 1
- GLGNSAPAWZUDRT-UHFFFAOYSA-N morpholine-4-sulfonic acid Chemical class OS(=O)(=O)N1CCOCC1 GLGNSAPAWZUDRT-UHFFFAOYSA-N 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- DRINJBFRTLBHNF-UHFFFAOYSA-N propane-2-sulfonyl chloride Chemical compound CC(C)S(Cl)(=O)=O DRINJBFRTLBHNF-UHFFFAOYSA-N 0.000 description 1
- HNDXKIMMSFCCFW-UHFFFAOYSA-N propane-2-sulphonic acid Chemical compound CC(C)S(O)(=O)=O HNDXKIMMSFCCFW-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960001124 trientine Drugs 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762611535 DE2611535A1 (de) | 1976-03-16 | 1976-03-16 | 6alpha-hydroxy-8alpha-oestradiole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1578862A true GB1578862A (en) | 1980-11-12 |
Family
ID=5972833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1061877A Expired GB1578862A (en) | 1976-03-16 | 1977-03-14 | 6-hydroxy-8-oestradiols |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS52111551A (es) |
| BE (1) | BE852527A (es) |
| CH (1) | CH628066A5 (es) |
| DE (1) | DE2611535A1 (es) |
| DK (1) | DK105377A (es) |
| FR (1) | FR2344571A1 (es) |
| GB (1) | GB1578862A (es) |
| IE (1) | IE45494B1 (es) |
| LU (1) | LU76944A1 (es) |
| MX (1) | MX4367E (es) |
| NL (1) | NL7701303A (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8602666D0 (sv) * | 1986-06-16 | 1986-06-16 | Leo Ab | Intravaginal devices |
-
1976
- 1976-03-16 DE DE19762611535 patent/DE2611535A1/de not_active Withdrawn
-
1977
- 1977-02-08 NL NL7701303A patent/NL7701303A/xx unknown
- 1977-03-03 MX MX549677U patent/MX4367E/es unknown
- 1977-03-10 DK DK105377A patent/DK105377A/da unknown
- 1977-03-11 CH CH311077A patent/CH628066A5/de not_active IP Right Cessation
- 1977-03-14 LU LU76944A patent/LU76944A1/xx unknown
- 1977-03-14 GB GB1061877A patent/GB1578862A/en not_active Expired
- 1977-03-14 IE IE54677A patent/IE45494B1/en unknown
- 1977-03-15 JP JP2855677A patent/JPS52111551A/ja active Pending
- 1977-03-16 FR FR7707793A patent/FR2344571A1/fr active Granted
- 1977-03-16 BE BE175835A patent/BE852527A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE852527A (fr) | 1977-09-16 |
| MX4367E (es) | 1982-04-19 |
| FR2344571A1 (fr) | 1977-10-14 |
| CH628066A5 (en) | 1982-02-15 |
| JPS52111551A (en) | 1977-09-19 |
| LU76944A1 (es) | 1977-07-14 |
| DE2611535A1 (de) | 1977-09-29 |
| FR2344571B1 (es) | 1979-03-09 |
| DK105377A (da) | 1977-09-17 |
| IE45494L (en) | 1977-09-16 |
| IE45494B1 (en) | 1982-09-08 |
| NL7701303A (nl) | 1977-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |