GB1571357A - Storable solid compositions for dilution with water to form aqueous peracid solutions - Google Patents
Storable solid compositions for dilution with water to form aqueous peracid solutions Download PDFInfo
- Publication number
- GB1571357A GB1571357A GB51233/77A GB5123377A GB1571357A GB 1571357 A GB1571357 A GB 1571357A GB 51233/77 A GB51233/77 A GB 51233/77A GB 5123377 A GB5123377 A GB 5123377A GB 1571357 A GB1571357 A GB 1571357A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- acid
- alkali
- acid anhydride
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 150000004965 peroxy acids Chemical class 0.000 title claims description 40
- 239000000243 solution Substances 0.000 title description 44
- 238000010790 dilution Methods 0.000 title description 5
- 239000012895 dilution Substances 0.000 title description 5
- 239000008247 solid mixture Substances 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims abstract description 66
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 14
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 11
- -1 alkali-metal salt Chemical class 0.000 claims description 24
- 229910052783 alkali metal Inorganic materials 0.000 claims description 20
- 239000000645 desinfectant Substances 0.000 claims description 19
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 239000003599 detergent Substances 0.000 claims description 12
- 229960001922 sodium perborate Drugs 0.000 claims description 12
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical group [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 150000008065 acid anhydrides Chemical class 0.000 claims description 10
- 238000005260 corrosion Methods 0.000 claims description 8
- 230000007797 corrosion Effects 0.000 claims description 8
- 239000003381 stabilizer Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 229920000388 Polyphosphate Polymers 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 229910000318 alkali metal phosphate Inorganic materials 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001205 polyphosphate Substances 0.000 claims description 4
- 235000011176 polyphosphates Nutrition 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 2
- MPCRDALPQLDDFX-UHFFFAOYSA-L Magnesium perchlorate Chemical compound [Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O MPCRDALPQLDDFX-UHFFFAOYSA-L 0.000 claims description 2
- 239000002250 absorbent Substances 0.000 claims description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 claims description 2
- 150000004973 alkali metal peroxides Chemical class 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 239000012964 benzotriazole Substances 0.000 claims description 2
- 230000003139 buffering effect Effects 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- HJMZMZRCABDKKV-UHFFFAOYSA-N carbonocyanidic acid Chemical compound OC(=O)C#N HJMZMZRCABDKKV-UHFFFAOYSA-N 0.000 claims description 2
- 230000000249 desinfective effect Effects 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims description 2
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 2
- 229960001484 edetic acid Drugs 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 125000005342 perphosphate group Chemical group 0.000 claims description 2
- 229920000151 polyglycol Polymers 0.000 claims description 2
- 239000010695 polyglycol Substances 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 239000011253 protective coating Substances 0.000 claims description 2
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 229960004365 benzoic acid Drugs 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 11
- 150000007513 acids Chemical class 0.000 abstract description 5
- 238000004090 dissolution Methods 0.000 abstract description 3
- 238000002844 melting Methods 0.000 abstract description 3
- 230000008018 melting Effects 0.000 abstract description 3
- 239000011241 protective layer Substances 0.000 abstract description 2
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 description 20
- RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 9
- GTDPSWPPOUPBNX-UHFFFAOYSA-N ac1mqpva Chemical compound CC12C(=O)OC(=O)C1(C)C1(C)C2(C)C(=O)OC1=O GTDPSWPPOUPBNX-UHFFFAOYSA-N 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000000721 bacterilogical effect Effects 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000001473 noxious effect Effects 0.000 description 5
- 239000008234 soft water Substances 0.000 description 5
- 241001478240 Coccus Species 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- SCKXCAADGDQQCS-UHFFFAOYSA-N Performic acid Chemical compound OOC=O SCKXCAADGDQQCS-UHFFFAOYSA-N 0.000 description 3
- 241000588769 Proteus <enterobacteria> Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- FWPVKDFOUXHOKQ-UHFFFAOYSA-N 2-[1-(carboxymethyl)cyclopentyl]acetic acid Chemical compound OC(=O)CC1(CC(O)=O)CCCC1 FWPVKDFOUXHOKQ-UHFFFAOYSA-N 0.000 description 2
- XIRDTMSOGDWMOX-UHFFFAOYSA-N 3,4,5,6-tetrabromophthalic acid Chemical compound OC(=O)C1=C(Br)C(Br)=C(Br)C(Br)=C1C(O)=O XIRDTMSOGDWMOX-UHFFFAOYSA-N 0.000 description 2
- WZHHYIOUKQNLQM-UHFFFAOYSA-N 3,4,5,6-tetrachlorophthalic acid Chemical compound OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C(O)=O WZHHYIOUKQNLQM-UHFFFAOYSA-N 0.000 description 2
- WCMNSFIBXDIFIR-UHFFFAOYSA-N 3,4,5,6-tetraphenylphthalic acid Chemical compound C=1C=CC=CC=1C=1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)C(C(=O)O)=C(C(O)=O)C=1C1=CC=CC=C1 WCMNSFIBXDIFIR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000588748 Klebsiella Species 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- UJMDYLWCYJJYMO-UHFFFAOYSA-N benzene-1,2,3-tricarboxylic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1C(O)=O UJMDYLWCYJJYMO-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- ADKBGLXGTKOWIU-UHFFFAOYSA-N butanediperoxoic acid Chemical compound OOC(=O)CCC(=O)OO ADKBGLXGTKOWIU-UHFFFAOYSA-N 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- UFOIOXZLTXNHQH-UHFFFAOYSA-N oxolane-2,3,4,5-tetracarboxylic acid Chemical compound OC(=O)C1OC(C(O)=O)C(C(O)=O)C1C(O)=O UFOIOXZLTXNHQH-UHFFFAOYSA-N 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940045872 sodium percarbonate Drugs 0.000 description 2
- 235000019830 sodium polyphosphate Nutrition 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- SRPWOOOHEPICQU-UHFFFAOYSA-N trimellitic anhydride Chemical compound OC(=O)C1=CC=C2C(=O)OC(=O)C2=C1 SRPWOOOHEPICQU-UHFFFAOYSA-N 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-naphthoquinone Chemical compound C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 description 1
- WVRNUXJQQFPNMN-UHFFFAOYSA-N 3-dodec-1-enyloxolane-2,5-dione Chemical compound CCCCCCCCCCC=CC1CC(=O)OC1=O WVRNUXJQQFPNMN-UHFFFAOYSA-N 0.000 description 1
- VQVIHDPBMFABCQ-UHFFFAOYSA-N 5-(1,3-dioxo-2-benzofuran-5-carbonyl)-2-benzofuran-1,3-dione Chemical compound C1=C2C(=O)OC(=O)C2=CC(C(C=2C=C3C(=O)OC(=O)C3=CC=2)=O)=C1 VQVIHDPBMFABCQ-UHFFFAOYSA-N 0.000 description 1
- HCXKTIWKRLLCJD-UHFFFAOYSA-N C1(C=2C(C(=O)O1)=CC=CC2)=O.C2(C(=C)CC(=O)O2)=O.C2(CCCC(=O)O2)=O.C2(C=C/C(=O)O2)=O.C2(CCC(=O)O2)=O Chemical compound C1(C=2C(C(=O)O1)=CC=CC2)=O.C2(C(=C)CC(=O)O2)=O.C2(CCCC(=O)O2)=O.C2(C=C/C(=O)O2)=O.C2(CCC(=O)O2)=O HCXKTIWKRLLCJD-UHFFFAOYSA-N 0.000 description 1
- MFDRXYZNYBHTNF-UHFFFAOYSA-N C1=CC(=C2C(=CC=C3C4=CC=C(C=5C(=CC=C(C1=C23)C45)C(=O)O)C(=O)O)C(=O)O)C(=O)O.[N+](=O)([O-])C4=C5C(C(=O)OC5=O)=CC=C4 Chemical compound C1=CC(=C2C(=CC=C3C4=CC=C(C=5C(=CC=C(C1=C23)C45)C(=O)O)C(=O)O)C(=O)O)C(=O)O.[N+](=O)([O-])C4=C5C(C(=O)OC5=O)=CC=C4 MFDRXYZNYBHTNF-UHFFFAOYSA-N 0.000 description 1
- JHVSISIDWXJLLS-UHFFFAOYSA-N C=1(C(=CC(=C(C1)C(=O)O)C(=O)O)C(=O)O)C(=O)O.C1(CC=2C(C(=O)O1)=CC=CC2)=O Chemical compound C=1(C(=CC(=C(C1)C(=O)O)C(=O)O)C(=O)O)C(=O)O.C1(CC=2C(C(=O)O1)=CC=CC2)=O JHVSISIDWXJLLS-UHFFFAOYSA-N 0.000 description 1
- BPDFNZBHRUGQNJ-UHFFFAOYSA-N CCCCCCCCCCCC(C)(C)NO Chemical compound CCCCCCCCCCCC(C)(C)NO BPDFNZBHRUGQNJ-UHFFFAOYSA-N 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241001400590 Richia Species 0.000 description 1
- AYVGBNGTBQLJBG-UHFFFAOYSA-N [3-(hydroxymethyl)cyclopentyl]methanol Chemical compound OCC1CCC(CO)C1 AYVGBNGTBQLJBG-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- CUBCNYWQJHBXIY-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O CUBCNYWQJHBXIY-UHFFFAOYSA-N 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 238000003421 catalytic decomposition reaction Methods 0.000 description 1
- WOSVXXBNNCUXMT-UHFFFAOYSA-N cyclopentane-1,2,3,4-tetracarboxylic acid Chemical compound OC(=O)C1CC(C(O)=O)C(C(O)=O)C1C(O)=O WOSVXXBNNCUXMT-UHFFFAOYSA-N 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940096118 ella Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid group Chemical group C(CCCC(=O)O)(=O)O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- VANNPISTIUFMLH-UHFFFAOYSA-N glutaric anhydride Chemical compound O=C1CCCC(=O)O1 VANNPISTIUFMLH-UHFFFAOYSA-N 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- OLAPPGSPBNVTRF-UHFFFAOYSA-N naphthalene-1,4,5,8-tetracarboxylic acid Chemical compound C1=CC(C(O)=O)=C2C(C(=O)O)=CC=C(C(O)=O)C2=C1C(O)=O OLAPPGSPBNVTRF-UHFFFAOYSA-N 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- CLYVDMAATCIVBF-UHFFFAOYSA-N pigment red 224 Chemical compound C=12C3=CC=C(C(OC4=O)=O)C2=C4C=CC=1C1=CC=C2C(=O)OC(=O)C4=CC=C3C1=C42 CLYVDMAATCIVBF-UHFFFAOYSA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- CZPZWMPYEINMCF-UHFFFAOYSA-N propaneperoxoic acid Chemical compound CCC(=O)OO CZPZWMPYEINMCF-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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Abstract
The novel, storage-stable mixtures which, upon dissolution in water, give solutions with antimicrobial activity, contain a substance which eliminates H2O2 and one or more odourless or low-odour carboxylic anhydrides with a melting point of not below 40 DEG C. Upon dissolution in water in the presence of H2O2, these latter substances are converted into low-odour water-soluble percarboxylic acids which offer potent antimicrobial activity. The carboxylic anhydrides and/or substances which eliminate H2O2 can be coated with inert, water-soluble protective layers.
Description
(54) STORABLE, SOLID COMPOSITIONS FOR DILUTION WITH WATER
TO FORM AQUEOUS PERACID SOLUTIONS
(71) We, SCHULKE & MAYR G.m.b.H.. a Company organised under the laws of the
Federal Republic of Germany, of Robert-Koch
Strasse 2, 2000 Norderstedt, Germany, do here bv declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: This invention relates to storable solid compositions for dilution with water to fonn aqueous peracid solutions, which act as antimicrobial agents and may be useful as disinfectants. Percarboxylic acids make excellent disinfectants, but to be able to use them as such it is desirable to have aqueous percarboxylic acid solutions with a high percarboxylic acid content but having a slight or only weak odour.
It is known that lower aliphatic monopercarboxylic acids, such as peracetic acid and perpropionic acid, are capable of forming stable solutions with a high peracid content. However, diluted forms of these solutions ready for use, e.g. as disinfectants, are not stable over long periods of time and are therefore not suitable to be sold in that form. Unfortunately, the stable concentrated peracid solutions have an extremely pungent odour which makes handling and use of them difficult and even hazardous.
The lower dicarboxylic acids, form watersoluble percarboxylic acids with little smell. In particular maleic acid, succinic acid and glutaric acid form almost odourless, water-soluble peracids. However, diluted solutions of these peracids, ready for use, are also not stable over extended periods of time. As indicated hereinafter only perglutaric acid of these peracids is capable of forming stable concentrated solutions.
If, for example, succinic acid anhydride is reacted with H202, then the initially high content of persuccinic acid diminishes during extended storage. The decomposition of the persuccinic acid leads to succinic acid crystallising out of solution. Peracid solutions obtained from maleic acid anhydride also lack stability over long periods. Perglutaric acid solutions with a high peracid content are stable, but only in the presence of excess H2O2. The solutions there described do require careful handling, preferably by those with adequate technical knowledge. Inappropriate treatment of any concentrated percarboxylic acid solution can give rise to violent decomposition reactions and corrosion which may result in damage to material. Impurities can also lead to catalytic decomposition, while storage at too high a temperature can lead to thermal decomposition.
The known compositions do not, therefore, provide a source of peracid in solution which is storable and non-corrosive, at the same time as being easy to handle.
In one aspect this invention provides a storable, solid composition for dilution with water to form aqueous peracid solutions, which comprises an H202 source and one or more non noxious carboxylic acid anhydrides (as detained hereinafter), the melting point of the anhydride(s) being not lower than 400C.
By the term "non-noxious carboxylic acid anhydrides" is meant compdunds which are themselves odourless or have only a slight odour and which dissolve in water in the presence of
H202 to form water-soluble antimicrobial peracids having no or only a slight odour. When the non-noxious anhydrides are dissolved in water in the absence of H202 they form watersoluble carboxylic acids, again having a slight odour, and advantageously such acids themselves have antimicrobial.activity.
The compositions of the invention may com prise a single carboxylic acid anhydride or a mixture of anhydrides. The anhydrides used may be simple carboxylic acid anhydrides (i.e. anhydrides of a single acid) or mixed carboxylic acid anhydrides, provided of course that they are non-noxious within the meaning of the term as set about above.
The structure - C - 0 - C II 11 0 0 can occur once, twice or n times in the anhydrides, 7t being an integer in the range 3 - 100.
Compounds with very many anhydride groups may, for example, be obtained by copolymeris ation of ethylenically-unsaturated compounds with maleic acid anhydride.
Non-noxious carboxylic acid anhydrides particularly suitable for use in the invention are readily available and include:
succinic acid anhydride
maleic acid anhydride
glutaric acid anhydride
phthalic acid anhydride
itaconic acid anhydride
benzoic acid anhydride
diglycolic acid anhydride
acetylcitric acid anhydride
dichloromaleic acid anhydride
3,3-dimethylglutaric acid anhydride 7,3-dimethylmaleic acid anhydride
2-dodecen-1-yl-succinic acid anhydride
homophthalic acid anhydride
3-methylglutaric acid anhydride
2-phenylglutaric acid anhydride
tetramethyleneglutaric acid anhydride
trimethylacetic acid anhydride
1 ,2,4,5-benzenetetracarboxylic acid anhydride
1,2,4-benzenetricarboxylic acid anhydride
1 j3-benzenetricarboxylic acid anhydride 3,3 ,4,4'-benzophenonetetracarboxylic acid di
anhydride naphthalene-1 4,5,8-tetracarboxylic acid dian
hydride 1 ,8-naphthalenic acid anhydride 3-nitro-plithalic acid anlWdride 3,4,9,10-perylenetetracarboxylic acid dianhy
dride
tetrabromo-phthalic acid dianhydride
tetrachloro-phthalic acid dianhydride
tetraphenyl-phthalic acid dianhydride bicycle.{2 '2,2,] -oct-7-en-2 ,3 5 ,6-tetracarboxylic
acid dianhydride - DL - camphoric acid anhy
dride
cis,cis,cis,cis cyclopentane-1,2,3 ,4-tetra-carb- oxylic acid dianhydride
cis 4cyclohexene-l ,2-dicarboxylic acid anhy
dride tetrahydrofuran-2,3,4,5-tetracarboxylic acid di
anhydride
Particularly preferred anhydrides are:
succinic acid anhydride
maleic acid anhydride
glutaric acid anhydride
phthalic acid anhydride
itaconic acid anhydride
homophthalic acid anhydride
1 ,2,4,5-benzenetetracarboxylic acid anhydride
and 1,2,4- and 1 ,2,3-benzenetricarboxylic acid anhydride
The compositions of the invention also contain an H202 source - that is to say, a compound which when the compositions are added to water is capable of generating H202 in the formed solution so that the anhydrides are converted to corresponding peracids. Suitable H202 sources include perborates, percarbonates, monopersulphates, dispersulphates, perphosphates, percarbamides and alkali-metal peroxides.
A preferred H202 source is sodium perborate.
The acid anhydrides react with sodium perborate and the other H202 sources in aqueous solution practically immediately to form the corresponding peracids, and this reaction may be so rapid that H2O2 is not actually generated for any finite time in the solution.
Whilst succinic acid anhydride and sodium perborate are stable in juxtaposition in pulverulent formulation and mixtures of these two in ingredients are still flowable after 6 weeks, it is advantageous for other carboxylic acid anhydrides and/or other H202 sources to be encased in water-soluble, chemically inert protective coatings which dissolve quickly in water with the release of the active ingredients. The coating may prevent coagulation and lead to better storage-stability of the products. Although not necessary the active substances in a mixture of succinic acid anhydride and sodium perborate may also be encased in a protective layer.
Examples of water soluble substances for use in such coatings are fatty acids and anionic and/ or non-ionic detergents for the carboxylic acid anhydrides and non-ionic and/or anionic detergents for the H202 sources. Suitable anionic detergents are alkylbenzoic sulphonates and lauryl sulphates, and suitable non-ionic detergents are alkylphenol polyglycol ethers, polyoxypropylene glycols (Pluronic - a Registered
Trade Mark) and aminoxides such as dimethyldodecylaminoxide and betaines.
Encasing the carboxylic acid anhydrides and/ or H202 sources with these materials may be carried out using known methods either before or after combining the active ingredients to form the compositions of the invention. For example, the active ingredients may be simply mixed or coated by spray drying with the inert materials. These inert materials can be used in solid form, in the form of a melt or as solution in an inert solvent, according to the method of application chosen.
The compositions of the invention may also contain water-absorbent agents capable of combining with traces of water. In this way coagulation of the compositions in the presence of moisture may be avoided so that the storability and consequently the antimicrobial activity of the disinfectant solutions prepared from the compositions may be improved. Such agents are well-known and examples include calcium chloride, calcium oxide, potassium carbonate, magnesium perchlorate, magnesium sulphate and sodium sulphate.
The molar ratio of acid anhydride to H202 source may be varied within broad ranges, preferably in the range of from 1:10 to 10:1 and is most preferably in the range 1:4 to 4:1. Preferably as many moles of sodium perborate are used per mole of anhydride as there are anhydride functions in the latter - thus, n moles of sodium perborate are used per mole of anhydride containing z anhydride functions. This gives a final pH in the range of 5 to 7, which is preferred since peracids tend to be unstable in alkaline conditions.
The compositions of the invention are solid, and may be in the form of powder or be formed into larger solid particles such as granules, pellets or tablets.
The compositions of the invention may also contain a variety of other components such as inert fillers, stabilising agents for the peracids and/or H2O2, agents for adjusting or buffering pH, corrosion inhibitors, perfumes, further antimicrobial substances, substances having cleaning activity, and a variety of inorganic and organic salts depending on the ultimate use intended for the compositions. Such additional materials are generally known, but by way of illustration, suitable stabilisers for H202 and/or the peracids are urea, alkali-metal metaphosphates, alkalimetal polyphosphates, pyridin-2,3-dicarboxylic acid, pyridin-2,6-dicarboxylic acid, citric acid and its alkali-metal salts, ethylenediaminetetracetic acid and its alkali-metal salts, and nitriloacetic acid and its alkali-metal salts. These stabilisers can be used in an amount of from 0.01 to 5% by weight of the composition, and preferably in an amount of from 0.1 to 5% by weight.
Benzotriazole, alkali-metal phosphates, alkyl phosphates and amine oxides can be used as corrosion inhibitors. These compounds are preferably employed in amounts ranging from 0.01 to 10% by weight of the composition and preferably 0.5 to 5% by weight.
Examples of further antimicrobial additives are sorbic acid, benzoic acid and salicylic acid.
To adjust and stabilise the pH value of the composition citric acid and its alkali-metal salts, alkali-metal phosphates, alkali-metal acetates, lactic acid and its alkali-metal salts, alkali-metal bisulphates, alkali-metal carbonates and alkalimetal bicarbonates may be used.
Substances with cleaning activity which may be included are, in addition to the detergents mentioned above, metaphosphates and polyphosphates.
The compositions of the invention possess good storability, dissolve in water immediately without the production of large amounts of heat of reaction and in doing so give a high yield of peracids, to form solutions having the excellent antimicrobial activity of the peracids.
The solutions formed are substantially odourless. Furthermore the carboxylic acids formed on decomposition of the peracids largely represent naturally-occurring compounds, so that they give no problems with unwanted residues.
This invention also provides a process for forming a disinfectant solution in which a composition of the invention is dissolved in water.
Naturally, the concentration of peracid in the disinfectant solution may be selected by dissolving an appropriate amount of the composition in water.
The preparation of a disinfectant solution containing a peracid by the addition to water of a composition comprising acid anhydride and a H202 source, and where present the extra additives set out above, has many advantages over a preparation comprising separate addition of the individual ingredients. By being added in an intimate mixture the ingredients go into better solution and a higher yield of active peracid is obtained. The disinfectant solution formed is more stable and its compatibility to other substances is greater.
If one puts the individual ingredients into water separately - that is, the acid anhydride first - then this anhydride is converted into acid. With the subsequent addition of the H202 source so much acid anhydride has already converted into acid that the reaction of the remaining anhydride with H202 leads to a substantially smaller peracid content. This results in insufficient disinfectant activity in the solution formed.
Conversely, if the H202 source is dissolved first, at least for a short period, a pH value is produced which can differ strongly from the final pH value of the solution. Thus, solutions may be formed with potassium monoperoxydisulphate (KIlSOs) as H202 source which are too acidic, while the use of perborates and percarbonates give solutions which are too alkaline.
Undesirable pH values can result in incompatibility with other substances and corrosion problems resulting in damage to the disinfectant solution. Above all if metal ions go into solution the peracid may be decomposed catalytically.
These disadvantages may also occur if the individual ingredients are added not one after the other but separately in the sense that (for instance, as a result of coagulation) one or other of the ingredients dissolves too slowly.
The acid anhydrides react in solution immediately with H202 or the H202 source itself to form a high yield of peracid. The solution obtained may contain, depending on whether mono- or higher functional carboxylic acid anhydrides are present and according to the ratio of acid anhydride : H202 source used, both monoperacids, diperacids and higher functional peracids, as well as mixtures of these peracids.
Moreover the solutions are sufficiently stable to produce excellent and effective antimicrobial activity.
The spectrum of activity of disinfectant solutions obtained according to the invention was established according to the methods described in "Guide Lines for the examination of chemical disinfectants", Gustav Fischer Verlag, Stuttgart,
Germany. The results are shown in the following Tests, which show disinfectant solutions prepared according to the invention and tested 30 minutes and 16 hours after dissolution.
The disinfectant solutions obtainable using the compositions of the invention can be used in the food industry to disinfect medical and dental instruments and to disinfect materials, for example in hospitals.
This invention extends to a method of disinfecting a locus infected with microbes, or liable to infection by microbes, in which the locus is treated with an effective amount of a disinfectant solution produced according to the invention.
The following Examples and Tests are now given, through only by way of illustration, to show certain preferred aspects of the invention.
EXAMPLE I
1.53 g of sodium perborate and 1.0 g of succinic acid anhydride were mixed together. This mixture was dissolved in soft water to give 100 g of an aqueous solution. The solution was clear and colourless and had a pH value of 5.3. It contained: after 20 minutes 13.6 mg of H202 and
863 mg of peracid after 40 minutes 10.9 mg of H202 and
863 mg of peracid after 60 minutes 10.9 mg of H202 and
852 mg of peracid after 94 hours 63.9 mg of H202 and
346 mg of peracid.
With the addition of Na3 PO4 to adjust the pH value to 7 the solution contained: after 24 hours 46.2 mg of H202 and
158 mg of peracid.
EXAMPLE 2
A colourless, odourless, flowable powder was prepared from 10 g of succinic acid anhydride, 15 g of sodium perborate, 25 g of sodium polyphosphate of average chain length (Calgon N "CALGON" is a Registered Trade Mark) and anhydrous Na2 S04 to make up to 100 g. After 22 days' storage the mixture was dissolved in water. This solution contained: after 20 minutes 748 mg of H202 and
7742 mg of peracid after 50 minutes 680 mg of H202 and
7742 mg of peracid after 80 minutes 476 mg of H202 and
5896 mg of peracid
EXAMPLE 3
10 g of finely-ground succinic acid anhydride were coated with 5 g of a fatty alcohol ethoxylate (C12 -C14 - fat alcohols with 25 ethylene oxide units) subsequently 15 g of sodium perborate, 25 g of sodium polyphosphate (Calgon
N) and sodium sulphate to 100 g were added.
For comparison a) a mixture without fat alcohol ethoxylate
coating; and b) a mixture without fat alcohol ethoxylate
coating and without sodium sulphate where also prepared.
After 60 days' storage at room temperature the mixtureb) (without coating and without sodium sulphate) showed the formation of lumps. After a further 60 days the formation of lumps was also noticed in mixture a) (without coating). The mixture containing encased succinic acid anhydride and sodium sulphate was still satisfactory after 120 days.
Tests: Bacteriological Ltvestigation The bacteriological investigation was carried out in accordance with the "Guidelines for the
Examination of Chemical Disinfectants", 3rd
Edition, published on behalf of the DGHM (Deutsche Gesellschaft fer Hygiene und Mikrobiologie) by Gustav Fischer Verlag, Stuttgart,
Germany, as there laid down for suspensions, germ-carriers and surfaces.
According to the DGHM Guidelines a disinfecting agent is effective if it kills the pathogenic germs (a) within 30 minutes in the suspension test and (b) within 6 hours in the surface test, at the same concentrations in each of the active substance. The germ-carriers test is a more severe one, in which absorbtive materials (such as the mineral granules and cambric respectively used below) are soaked in dispersions of the pathogenic germs before treatment with the active substance.
The results secured according to the DGHM tests were as set out in the following Tables:
WHAT WE CLAIM IS:
1. A storable, solid composition for dilution with water to form aqueous peracid solutions, which comprises an H202 source and one or more non-noxious carboxylic acid anhydrides (as herein defined), the melting point of the anhydride(s) being not lower than 40"C.
2. A composition as claimed in claim 1, which comprises one or more of:
succinic acid anhydride
maleic acid anhydride
glutaric acid anhydride
phthalic acid anhydride
itaconic acid anhydride
benzoic acid anhydride
diglycolic acid anhydride
dichloromaleic acid anhydride 3,3-dimethylglutaric acid anhydride
2,3-dimethylmaleic acid anhydride 2-dodecen-1-yl-succinic acid anhydride
homophthalic acid anhydride
3-methylglutaric acid anhydride
2-phenylglutaric acid anhydride
tetramethyleneglutaric acid anhydride
trimethylacetic acid anhydride 1,2,4,5 -benzenetetracarboxylic acid anhy
dride 1,2 ,4-benzenetricarboxylic acid anhydride 1,2l3-benzenetricarboxylic acid anhydride
3,3 ,4,4'-benzophenonetetracarboxylic acid
dianhydride naphthalene-1,4,5 ,8-tetracarboxylic acid di
anhydride TABLE 1 Composition -1.0 g Succinic acid anhydride 1.5 g Sodium perborate
Soft water to make up to 100 g.
Bacteriological results (DGHM) 30 minutes after the mixture has dissolved.
Suspension, Bacteria Suspension, Fungi Germ Carrier Staphylo- Esche
Grains Cambric coccus richia aureus coli Surfaces concen- Staphylo- Klebsi- Pyo- Proteus Tricho- Candida Asper- Bacil- Mycobac- PVC Wood PVC Wood tration coccus ella genes vulgaris phyton albicans gillus lus sub- terium Var- Varaureus pneumon. menta- niger tilis smegmatis nish nish grophytes 2 > 30' > 30' > 30' > 30' 5 15' 15' 15' 30' 10 5' 5' 5' 15' 25 5' 2 ' 2 ' 2 ' 3h > 120' 1h 1h 1h 1h 50 2 ' 2 ' 2 ' 2 ' 1h > 120' 1h 1h 1h 1h 100 > 30' > 30' > 30' 1h > 120' 1h 1h 1h 1h + 20% Serum > 30' > 30' > 30' > 30' 5 > 30' > 30' > 30' 30' 10 30' 15' 15' 15' 25 2 ' 2 ' 2 ' 2 ' M H K TABLE 2
Composition: 1.0 g Succinic acid anhydride
1.5 g Sodium perborate
soft water to make up to 100 g
Bacteriological results (DGHM)
16 hours after the mixture has dissolved
Suspension, Bacteria
Concentration Staphylo- Klebsiella Pyogenes Proteus coccus pneumon. vulgaris aureus.
10 15' 5' 1 15' 21/2' 25 2 1/2' 2 1/2' 2 1/2' 2 1/2' 50 2 1/2' 2 1/2' 2 1/2' 2 1/2' TABLE 3
Composition: A) 0.94 g Maleic acid anhydride
1.5 g Sodium percarbonate
Soft water to make up to 100 g
B) 1.14 g Glutaric acid anhydride
1.5 g Sodium percarbonate
soft water to make up to 100 g
Bacteriological results (DGHM) 30 minutes after the mixtures have dissolved
Suspension, Bacteria
Concentration Staphylo- Klebsiella Pyogenes Proteus coccus pneumon. vulgaris aureus.
A) 5 > 30' 30' 15' 15' 10 15' 30' 5' 15' 25 5' 2 1/2' 2 1/2' 2 1/2' B) 5 15' 15' 5' 15' 10 5' 5' 21/2' 2 1/2' 25 2 1/2' 2 1/2' 2 1/2' 2 1/2' 1 ,8-naphthalenic acid anhydride 3-nitro-phthalic acid anhydride 3,4,9,10-perylenetetracarboxylic acid dianhy
dride tetrabromo-phthalic acid dianhydride tetrachloro-phthalic acid dianhydride tetraphenyl-phthalic acid dianhydride bicyclo-[2,2,2] -oct-7en-2,3,5,6-tetracarb- oxylic acid dianhydride - DL - camphoric acid anhydride cis, cis, cis, cis cyclopentane-1 '2,3 4-tetra- carboxylic acid dianhydride cis 4-cyclohexene-l ,2-dicarboxylic acid di
anhydride tetrahydrofuran-2,3,4,5-tetracarboxylic acid
anhydride
Claims (1)
- 3. A composition as claimed in claim 1 or claim 2, in which the H202 source is or includes a perborate, percarbonate, monopersulphate, dispersulphate, perphosphate, percarbamide or alkali-metal peroxide.4. A composition as claimed in claim 3, in which the H202 source is sodium perborate.5. A composition as claimed in any of the preceding claims, in which the or each carboxylic acid anhydride and/or the H202 source is encased in a water-soluble, chemically inert protective coating.6. A composition as claimed in claim 5, in which the or each carboxylic acid anhydride is coated with a fatty acid or an anionic and/or non-ionic detergent, and/the H202 source is coated with a non-ionic and/or anionic detergent.7. A composition as claimed in claim 6, in which the anionic detergent is an alkylbenzoic sulphonate or a lauryl sulphate and/or the nonionic detergent is an alkylphenol polyglycol ether, a polyoxypropylene glycol or an aminoxide.8. A composition as claimed in any of the preceding claims, which also contains a waterabsorbent agent.9. A composition as claimed in claim 8, in which the water-absorbent agent is calcium chloride, calcium oxide, potassium carbonate, magnesium perchlorate, magnesium sulphate or sodium sulphate.10. A composition as claimed in any of the preceding claims, in which the molar ratio of acid anhydride to H202 source is in the range offrom 1:10 to 10:1.11. A composition as claimed in claim 10, in which the molar ratio is from 1:4 to 4:1.12. A composition as claimed in any of the preceding claims, in which the pH is in the range of from 5 to 7.13. A composition as claimed in any of the preceding claims, which also contains one or more of inert fillers, stabilising agents for the peracids and/or H2O2, agents for adjusting or buffering pH, corrosion inhibitors, perfumes, antimicrobial substances, substances having cleaning activity, and inorganic and organic salts.14. A composition as claimed in claim 13, in which the stabiliser for H202 and/or the peracids is urea, alkali-metal metaphosphates, alkalimetal polyphosphates, pyridin-2,3-dicarboxylic acid, pyridin-2,6-dicarboxylic acid, citric acid or an alkali-metal salt thereof, ethylenediaminetetracetic acid or an alkali-metal salt thereof, or nitriloacetic acid or an alkali-metal salt thereof.15. A composition as claimed in claim 14, in which the stabiliser comprises from 0.01 to 5% by weight of the composition.16. A composition as claimed in claim 15, in which the stabiliser comprises from 0.1 to 5% by weight of the composition.17. A composition as claimed in any of claims 13 to 16, in which the corrosion inhibitor is benzotriazole, an alkali-metal phosphate, or alkyl phosphate or an amine oxide.18. A composition as clainied in claim 17, in which the corrosion inhibitor comprises from 0.01 to 10% by weight of the composition.19. A composition as claimed in claim 18, in which the corrosion inhibitor comprises from 0.5 to 5% by weight of the composition.20. A composition as claimed in any of claims 13 to 19, in which the antimicrobial substance is sorbic acid, benzoic acid or salicylic acid.21. A composition as claimed in any of claims 13 to 20, in which the pH value of the composition is adjusted or stabilised with citric acid, an alkali-metal salt thereof, an alkali-metal phosphate, an alkali-metal acetate, lactic acid or an alkali-metal salt thereof, an alkali-metal bisulphate, an alkali-metal carbonate or an alkalimetal bicarbonate.22. A composition as claimed in any of claims 13 to 21, which contains a metaphosphase or polyphosphate.23. A composition as claimed in any of the preceding claims, in the form of a powder, granules, pellets or tablets.24. A composition as claimed in claim 1 and substantially as described herein with reference to any one of the Examples.25. A process for forming a disinfectant solution in which a composition as claimed in any of claims 1 to 24 is dissolved in water.26. A process as claimed in claim 25 and substantially as described herein with reference to any one of the Examples.27. A method of disinfecting a locus infected with microbes, or liable to infection by microbes, in which the locus is treated with an effective amount of a disinfectant solution formed by a process as claimed in claim 25 or claim 26.28. A method as claimed in claim 27 and substantially as described herein with reference to any one of the Tests.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2655599A DE2655599B2 (en) | 1976-12-08 | 1976-12-08 | Storable mixture, which when dissolved in water, gives a solution with an antimicrobial effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1571357A true GB1571357A (en) | 1980-07-16 |
Family
ID=5994990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB51233/77A Expired GB1571357A (en) | 1976-12-08 | 1977-12-08 | Storable solid compositions for dilution with water to form aqueous peracid solutions |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS53104728A (en) |
| AT (1) | ATA794177A (en) |
| BE (1) | BE861276A (en) |
| BR (1) | BR7708103A (en) |
| CH (1) | CH631868A5 (en) |
| DE (1) | DE2655599B2 (en) |
| DK (1) | DK548277A (en) |
| FI (1) | FI60097C (en) |
| FR (1) | FR2373292A1 (en) |
| GB (1) | GB1571357A (en) |
| IE (1) | IE46271B1 (en) |
| IT (1) | IT1090553B (en) |
| LU (1) | LU78599A1 (en) |
| NL (1) | NL7712850A (en) |
| NO (1) | NO146621C (en) |
| SE (1) | SE7713799L (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3615787A1 (en) * | 1986-05-10 | 1987-11-12 | Fresenius Ag | Disinfectant |
| WO1995020876A1 (en) * | 1994-02-07 | 1995-08-10 | Warwick International Group Limited | Oxidising compositions |
| DE19962344A1 (en) | 1999-12-23 | 2001-07-12 | Henkel Ecolab Gmbh & Co Ohg | Methods and agents for cleaning and disinfecting sensitive medical devices |
| US6627657B1 (en) | 2000-03-22 | 2003-09-30 | Ecolab Inc. | Peroxycarboxylic acid compositions and methods of use against microbial spores |
-
1976
- 1976-12-08 DE DE2655599A patent/DE2655599B2/en not_active Ceased
-
1977
- 1977-11-07 AT AT794177A patent/ATA794177A/en not_active Application Discontinuation
- 1977-11-14 CH CH1388177A patent/CH631868A5/en not_active IP Right Cessation
- 1977-11-21 FI FI773513A patent/FI60097C/en not_active IP Right Cessation
- 1977-11-22 NL NL7712850A patent/NL7712850A/en not_active Application Discontinuation
- 1977-11-28 LU LU78599A patent/LU78599A1/xx unknown
- 1977-11-28 BE BE182987A patent/BE861276A/en not_active IP Right Cessation
- 1977-11-30 FR FR7736032A patent/FR2373292A1/en active Granted
- 1977-12-06 BR BR7708103A patent/BR7708103A/en unknown
- 1977-12-06 SE SE7713799A patent/SE7713799L/en not_active Application Discontinuation
- 1977-12-07 IE IE2492/77A patent/IE46271B1/en unknown
- 1977-12-07 IT IT52106/77A patent/IT1090553B/en active
- 1977-12-07 NO NO774178A patent/NO146621C/en unknown
- 1977-12-08 JP JP14769477A patent/JPS53104728A/en active Pending
- 1977-12-08 DK DK548277A patent/DK548277A/en not_active Application Discontinuation
- 1977-12-08 GB GB51233/77A patent/GB1571357A/en not_active Expired
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6540960B2 (en) | 1996-12-11 | 2003-04-01 | Henkel-Ecolab Gmbh & Co. Ohg (Henkel-Ecolab) | Process for disinfecting instruments |
| WO2001006856A1 (en) * | 1999-07-27 | 2001-02-01 | Ecolab Inc. | Peracid forming system, peracid forming composition, and methods for making and using |
| US6319888B2 (en) | 1999-07-27 | 2001-11-20 | Ecolab, Inc. | Peracid forming system, peracid forming composition, and methods for making and using |
| US6384006B1 (en) | 1999-07-27 | 2002-05-07 | Ecolab Inc. | Peracid forming system, peracid forming composition, and methods for making and using |
| WO2003001911A1 (en) * | 2001-06-28 | 2003-01-09 | Fmc Technologies, Inc. | Composition and process for reducing bacterial citrus canker organisms |
| US6506417B1 (en) | 2001-06-28 | 2003-01-14 | Fmc Technologies, Inc. | Composition and process for reducing bacterial citrus canker organisms |
| US10377971B2 (en) | 2012-09-13 | 2019-08-13 | Ecolab Usa Inc. | Detergent composition comprising phosphinosuccinic acid adducts and methods of use |
| US11053458B2 (en) | 2012-09-13 | 2021-07-06 | Ecolab Usa Inc. | Hard surface cleaning compositions comprising phosphinosuccinic acid adducts and methods of use |
| US9994799B2 (en) | 2012-09-13 | 2018-06-12 | Ecolab Usa Inc. | Hard surface cleaning compositions comprising phosphinosuccinic acid adducts and methods of use |
| US10358622B2 (en) | 2012-09-13 | 2019-07-23 | Ecolab Usa Inc. | Two step method of cleaning, sanitizing, and rinsing a surface |
| US9670434B2 (en) | 2012-09-13 | 2017-06-06 | Ecolab Usa Inc. | Detergent composition comprising phosphinosuccinic acid adducts and methods of use |
| US12371639B2 (en) | 2012-09-13 | 2025-07-29 | Ecolab Usa Inc. | Hard surface cleaning compositions comprising phosphinosuccinic acid adducts and methods of use |
| US11001784B2 (en) | 2012-09-13 | 2021-05-11 | Ecolab Usa Inc. | Detergent composition comprising phosphinosuccinic acid adducts and methods of use |
| US9752105B2 (en) | 2012-09-13 | 2017-09-05 | Ecolab Usa Inc. | Two step method of cleaning, sanitizing, and rinsing a surface |
| US11952556B2 (en) | 2012-09-13 | 2024-04-09 | Ecolab Usa Inc. | Detergent composition comprising phosphinosuccinic acid adducts and methods of use |
| US11859155B2 (en) | 2012-09-13 | 2024-01-02 | Ecolab Usa Inc. | Hard surface cleaning compositions comprising phosphinosuccinic acid adducts and methods of use |
| US11865219B2 (en) | 2013-04-15 | 2024-01-09 | Ecolab Usa Inc. | Peroxycarboxylic acid based sanitizing rinse additives for use in ware washing |
| US12337073B2 (en) | 2013-04-15 | 2025-06-24 | Ecolab Usa Inc. | Peroxycarboxylic acid based sanitizing rinse additives for use in ware washing |
| US11723361B2 (en) | 2015-07-17 | 2023-08-15 | Next Science IP Holdings Pty Ltd | Antimicrobial composition having efficacy against endospores |
| CN111424419B (en) * | 2020-05-22 | 2022-11-04 | 无锡浦惠恒业纺织科技有限公司 | Hydrogen peroxide catalytic system containing benzophenone structure derivative and application of hydrogen peroxide catalytic system in low-temperature pretreatment of textiles |
| CN111424419A (en) * | 2020-05-22 | 2020-07-17 | 无锡浦惠恒业纺织科技有限公司 | Hydrogen peroxide catalytic system containing benzophenone structure derivative and application of hydrogen peroxide catalytic system in low-temperature pretreatment of textiles |
Also Published As
| Publication number | Publication date |
|---|---|
| FI60097C (en) | 1981-12-10 |
| DE2655599B2 (en) | 1978-09-28 |
| JPS53104728A (en) | 1978-09-12 |
| DK548277A (en) | 1978-06-09 |
| FI60097B (en) | 1981-08-31 |
| IE46271L (en) | 1978-06-08 |
| DE2655599A1 (en) | 1978-06-22 |
| NO774178L (en) | 1978-06-09 |
| FI773513A7 (en) | 1978-06-09 |
| NO146621B (en) | 1982-08-02 |
| IE46271B1 (en) | 1983-04-20 |
| ATA794177A (en) | 1979-09-15 |
| NO146621C (en) | 1982-11-10 |
| BR7708103A (en) | 1978-08-15 |
| CH631868A5 (en) | 1982-09-15 |
| NL7712850A (en) | 1978-06-12 |
| FR2373292A1 (en) | 1978-07-07 |
| SE7713799L (en) | 1978-06-09 |
| LU78599A1 (en) | 1978-04-20 |
| IT1090553B (en) | 1985-06-26 |
| BE861276A (en) | 1978-03-16 |
| FR2373292B1 (en) | 1980-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |