GB1551054A - Syntheses of vinblastine vincristine and vinrosidine - Google Patents
Syntheses of vinblastine vincristine and vinrosidineInfo
- Publication number
- GB1551054A GB1551054A GB1284476A GB1284476A GB1551054A GB 1551054 A GB1551054 A GB 1551054A GB 1284476 A GB1284476 A GB 1284476A GB 1284476 A GB1284476 A GB 1284476A GB 1551054 A GB1551054 A GB 1551054A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vinrosidine
- syntheses
- vinblastine vincristine
- vinblastine
- vincristine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title 2
- JXLYSJRDGCGARV-KSNABSRWSA-N ac1l29ym Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-KSNABSRWSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960003048 vinblastine Drugs 0.000 title 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 title 1
- 229960004528 vincristine Drugs 0.000 title 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1
- 229950003670 vinrosidine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PK8176 | 1976-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1551054A true GB1551054A (en) | 1979-08-22 |
Family
ID=19935979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1284476A Expired GB1551054A (en) | 1976-03-04 | 1976-05-07 | Syntheses of vinblastine vincristine and vinrosidine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1551054A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2611202A1 (en) * | 1987-01-22 | 1988-08-26 | Univ British Columbia | PROCESS FOR THE SYNTHESIS OF DIMERED ALKALOID COMPOUNDS |
| US4767855A (en) * | 1985-06-03 | 1988-08-30 | P. F. Medicament | Process for the preparation of vincristine |
| US4778885A (en) * | 1986-09-18 | 1988-10-18 | Allelix Inc. | Production of alkaloid dimers using ferric ion |
| US4897477A (en) * | 1985-03-12 | 1990-01-30 | University Of Vermont & State Agricultural College | Synthesis of vinblastine and vincristine type compounds |
| EP0386972A3 (en) * | 1989-03-04 | 1991-04-10 | Mitsui Petrochemical Industries, Ltd. | Process for the preparation of binary indole alkaloids |
| BE1003068A4 (en) * | 1987-01-22 | 1991-11-12 | Univ British Columbia | Dimer alkaloid compound synthesis method |
| US5206699A (en) | 1988-05-06 | 1993-04-27 | Gersan Establishment | Sensing a narrow frequency band of radiation and gemstones |
-
1976
- 1976-05-07 GB GB1284476A patent/GB1551054A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897477A (en) * | 1985-03-12 | 1990-01-30 | University Of Vermont & State Agricultural College | Synthesis of vinblastine and vincristine type compounds |
| US4767855A (en) * | 1985-06-03 | 1988-08-30 | P. F. Medicament | Process for the preparation of vincristine |
| US4778885A (en) * | 1986-09-18 | 1988-10-18 | Allelix Inc. | Production of alkaloid dimers using ferric ion |
| FR2611202A1 (en) * | 1987-01-22 | 1988-08-26 | Univ British Columbia | PROCESS FOR THE SYNTHESIS OF DIMERED ALKALOID COMPOUNDS |
| BE1003068A4 (en) * | 1987-01-22 | 1991-11-12 | Univ British Columbia | Dimer alkaloid compound synthesis method |
| US5206699A (en) | 1988-05-06 | 1993-04-27 | Gersan Establishment | Sensing a narrow frequency band of radiation and gemstones |
| EP0386972A3 (en) * | 1989-03-04 | 1991-04-10 | Mitsui Petrochemical Industries, Ltd. | Process for the preparation of binary indole alkaloids |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |