GB1429339A - Bis-n-heterocyclic compounds - Google Patents
Bis-n-heterocyclic compoundsInfo
- Publication number
- GB1429339A GB1429339A GB2837173A GB2837173A GB1429339A GB 1429339 A GB1429339 A GB 1429339A GB 2837173 A GB2837173 A GB 2837173A GB 2837173 A GB2837173 A GB 2837173A GB 1429339 A GB1429339 A GB 1429339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- nitro
- amino
- alkylamino
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 hydroxy, methoxy, amino Chemical group 0.000 abstract 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- MOVDVILBUKJEBA-UHFFFAOYSA-N 2-amino-5-nitro-N-[2-(5-nitrofuran-2-yl)-4-oxo-1,2-dihydroquinazolin-3-yl]benzamide Chemical compound [N+](=O)([O-])C1=CC=C(O1)C1NC2=CC=CC=C2C(N1NC(C1=C(C=CC(=C1)[N+](=O)[O-])N)=O)=O MOVDVILBUKJEBA-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/92—Oxygen atoms with hetero atoms directly attached to nitrogen atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1429339 Bis - N - heterocyclic ketones HOECHST AG 14 June 1973 [15 June 1972 (4)] 28371/73 Heading C2C Novel compounds (I), (II) and (III) where R represents an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms; an unsubstituted or substituted phenyl group in which the substituents may be one or more groups selected from hydroxy, methoxy, amino, alkylamino, methyl, trifluoromethyl, nitro, cyano, carboxyl, and sulphonic acid groups, and fluorine, chlorine, and bromine atoms, an aralkyl group in which the aryl nucleus may be substituted with one or more of the substituents described above; or a heterocyclic group, for example, nitrofuryl group; R 1 and R<SP>1</SP> 1 which may be the same or different, each represents a hydroxy, methoxy, amino, alkylamino, methyl, trifluoromethyl, nitro, cyano, carboxyl or sulphonic acid group or a hydrogen, fluorine, chlorine or bromine atom, and n is the integer 1 or 2, are made by treating compounds (IV) with a diazotizing agent and/or with RCHO. N - [2 - (5 - nitrofuran - 2 - yl) - 1,2,3,4 - tetrahydroquinazolin - 4 - one - 3 - yl] - 5 - nitro - 2- amino-benzamide is also prepared. Pharmaceutical preparations having activity against gram-positive bacteria contain (I), (II) and/or (III) as active ingredient.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN556CA1972 | 1972-06-15 | ||
| IN558CA1972 | 1972-06-15 | ||
| IN555CA1972 | 1972-06-15 | ||
| IN557CA1972 | 1972-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1429339A true GB1429339A (en) | 1976-03-24 |
Family
ID=27452568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2837173A Expired GB1429339A (en) | 1972-06-15 | 1973-06-14 | Bis-n-heterocyclic compounds |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU5686473A (en) |
| CA (1) | CA992966A (en) |
| GB (1) | GB1429339A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804756A (en) * | 1984-09-26 | 1989-02-14 | Ortho Pharmaceutical Corporation | Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones |
| EP2722328A1 (en) * | 2012-10-19 | 2014-04-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Novel compounds with protective activity against toxins with intracellular action mode |
-
1973
- 1973-06-13 AU AU56864/73A patent/AU5686473A/en not_active Expired
- 1973-06-14 GB GB2837173A patent/GB1429339A/en not_active Expired
- 1973-06-15 CA CA174,217A patent/CA992966A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804756A (en) * | 1984-09-26 | 1989-02-14 | Ortho Pharmaceutical Corporation | Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones |
| EP2722328A1 (en) * | 2012-10-19 | 2014-04-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Novel compounds with protective activity against toxins with intracellular action mode |
Also Published As
| Publication number | Publication date |
|---|---|
| CA992966A (en) | 1976-07-13 |
| AU5686473A (en) | 1974-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |