GB1423089A - Furopyrrole derivatives - Google Patents
Furopyrrole derivativesInfo
- Publication number
- GB1423089A GB1423089A GB3981274A GB3981274A GB1423089A GB 1423089 A GB1423089 A GB 1423089A GB 3981274 A GB3981274 A GB 3981274A GB 3981274 A GB3981274 A GB 3981274A GB 1423089 A GB1423089 A GB 1423089A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- possibly
- analgesic
- halogenated
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 2
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960001301 amobarbital Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 abstract 1
- 229960004782 chlordiazepoxide Drugs 0.000 abstract 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
- -1 codiene Chemical compound 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229960003878 haloperidol Drugs 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 229960000482 pethidine Drugs 0.000 abstract 1
- 229960003893 phenacetin Drugs 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 229960002695 phenobarbital Drugs 0.000 abstract 1
- WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 abstract 1
- 229960002324 trifluoperazine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1423089 Analgesic &c medicines ICI UNITED STATES INC 12 Sept 1974 39812/74 Heading A5B [Also in Division C2] Therapeutic compositions having analgesic and in some cases antiinflammatory activity comprise compounds of formula I (or, where appropriate their pharmaceutically acceptable acid addition salts), wherein R 1 is H, C 1-3 alkyl, isobutyl, tert-butyl, C 4-8 cycloalkyl, C 3-4 alk-2 or 3-enyl, Ph, C 8-10 Ph-alkyl (possibly ring-halogenated), or R<SP>1</SP> is RCO, where R is C 1-3 alkyl, Ph (possibly substituted by MeO or by 1-2 halogen atoms or Me groups), C 7-9 Ph-alkyl (possibly ring-halogenated), pyridyl or thienyl. The compositions may be administered orally, parenterally or rectally, and may contain additionally (e.g.) one or more of aspirin, phenacetin, codiene, pethidine, morphine, chloropromazine, prochloroperazine, trifluoperazine, haloperidol, chlordiazepoxide, phenobarbitone and amylobarbitone.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3981274A GB1423089A (en) | 1974-09-12 | 1974-09-12 | Furopyrrole derivatives |
| BE148899A BE820345A (en) | 1974-09-12 | 1974-09-25 | FUROPYRROLE DERIVATIVES. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3981274A GB1423089A (en) | 1974-09-12 | 1974-09-12 | Furopyrrole derivatives |
| BE820345 | 1974-09-25 | ||
| BE148899A BE820345A (en) | 1974-09-12 | 1974-09-25 | FUROPYRROLE DERIVATIVES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1423089A true GB1423089A (en) | 1976-01-28 |
Family
ID=27158534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3981274A Expired GB1423089A (en) | 1974-09-12 | 1974-09-12 | Furopyrrole derivatives |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE820345A (en) |
| GB (1) | GB1423089A (en) |
-
1974
- 1974-09-12 GB GB3981274A patent/GB1423089A/en not_active Expired
- 1974-09-25 BE BE148899A patent/BE820345A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE820345A (en) | 1975-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |