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GB1412591A - Antiviral ds rna and compositions thereof - Google Patents

Antiviral ds rna and compositions thereof

Info

Publication number
GB1412591A
GB1412591A GB5542571A GB5542571A GB1412591A GB 1412591 A GB1412591 A GB 1412591A GB 5542571 A GB5542571 A GB 5542571A GB 5542571 A GB5542571 A GB 5542571A GB 1412591 A GB1412591 A GB 1412591A
Authority
GB
United Kingdom
Prior art keywords
ribonucleic acid
component
polyanion
double
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5542571A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB5542571A priority Critical patent/GB1412591A/en
Publication of GB1412591A publication Critical patent/GB1412591A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1412591 Antiviral RNA complexes BEECHAM GROUP Ltd 21 Nov 1972 [30 Nov 1971] 55425/71 Heading C3H [Also in Division A5] An antiviral ds RNA complex which is a principally ionic complex, the cationic component being a non-cross-linked polypeptide in which at least 50% of the component amino acids are basic, the free amino acid group or groups of which are protonated, and the anionic component being either (a) double-stranded ribonucleic acid polyanion, said double-stranded ribonucleic acid being of natural origin or (b) a polyanion of a double-stranded derivative of a double-stranded ribonucleic acid of natural origin. The catioric component is preferably a non-cross-linked polypeptide in which at least 70% of the component amino acids are basic, the free amino acid group or groups of which are protonated and may be, e.g. polylysine, polyornithine, a protamine, or polyarginine. The polyanion is preferably the polyanion of the ribonucleic acid found in infected strains of Penicillium chrysogenum, P. stoloniferum, Aspergillus niger or A. foetidus, or of the ribonucleic acid of the replicative form of a phage, e.g. the MU-9 mutant of MS2 coliphage.
GB5542571A 1971-11-30 1971-11-30 Antiviral ds rna and compositions thereof Expired GB1412591A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5542571A GB1412591A (en) 1971-11-30 1971-11-30 Antiviral ds rna and compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5542571A GB1412591A (en) 1971-11-30 1971-11-30 Antiviral ds rna and compositions thereof

Publications (1)

Publication Number Publication Date
GB1412591A true GB1412591A (en) 1975-11-05

Family

ID=10473869

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5542571A Expired GB1412591A (en) 1971-11-30 1971-11-30 Antiviral ds rna and compositions thereof

Country Status (1)

Country Link
GB (1) GB1412591A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009498A4 (en) * 1978-01-16 1980-10-16 Univ Boston Effecting cellular uptake of molecules.
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
EP0213921A3 (en) * 1985-08-26 1988-01-07 Hem Research, Inc. Modulation of virus-related events by double-stranded rnas
US4820696A (en) * 1985-08-26 1989-04-11 Hem Research, Inc. Modulation of aids virus-related events by double-stranded RNAS
WO1990000894A1 (en) * 1988-07-19 1990-02-08 Laboratoires Serobiologiques Cyto-photo-protector agent based on nucleic acids and/or their derivatives
DE3990820T1 (en) * 1988-07-19 1990-07-19 Serobiologiques Lab Sa LIGHT PROTECTION AGENT FOR SKIN CELLS BASED ON NUCLEIC ACIDS AND / OR THEIR DERIVATIVES
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
EP1541690A3 (en) * 1999-09-09 2005-07-27 CureVac GmbH Transfer of mRNA using polycationic compounds

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009498A4 (en) * 1978-01-16 1980-10-16 Univ Boston Effecting cellular uptake of molecules.
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
US4820696A (en) * 1985-08-26 1989-04-11 Hem Research, Inc. Modulation of aids virus-related events by double-stranded RNAS
EP0213921A3 (en) * 1985-08-26 1988-01-07 Hem Research, Inc. Modulation of virus-related events by double-stranded rnas
WO1990000894A1 (en) * 1988-07-19 1990-02-08 Laboratoires Serobiologiques Cyto-photo-protector agent based on nucleic acids and/or their derivatives
DE3990820T1 (en) * 1988-07-19 1990-07-19 Serobiologiques Lab Sa LIGHT PROTECTION AGENT FOR SKIN CELLS BASED ON NUCLEIC ACIDS AND / OR THEIR DERIVATIVES
GB2233557A (en) * 1988-07-19 1991-01-16 Serobiologiques Lab Sa Cyto-photo-protector agent based on nucleic acids and/or their derivatives
GB2233557B (en) * 1988-07-19 1993-03-31 Serobiologiques Lab Sa An agent for cytoprotection based on nucleic acids and/or derivatives thereof
DE3990820C2 (en) * 1988-07-19 2001-02-15 Lab Serobiologiques Pulnoy Light stabilizers for skin cells based on ribonucleic acids and derivatives thereof, as well as derivatives of ribonucleotides
EP1541690A3 (en) * 1999-09-09 2005-07-27 CureVac GmbH Transfer of mRNA using polycationic compounds
EP1619254A1 (en) * 1999-09-09 2006-01-25 CureVac GmbH Transfer of mRNA using polycationic compounds
EP1818409A1 (en) * 1999-09-09 2007-08-15 CureVac GmbH Transfer of mRNAusing polycationic compounds

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee