GB1480089A - Diluent composition for biologically active materials - Google Patents
Diluent composition for biologically active materialsInfo
- Publication number
- GB1480089A GB1480089A GB5160674A GB5160674A GB1480089A GB 1480089 A GB1480089 A GB 1480089A GB 5160674 A GB5160674 A GB 5160674A GB 5160674 A GB5160674 A GB 5160674A GB 1480089 A GB1480089 A GB 1480089A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ions
- meq
- liquid composition
- composition
- diluent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003085 diluting agent Substances 0.000 title abstract 3
- 239000011149 active material Substances 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 3
- 239000008367 deionised water Substances 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 102000013563 Acid Phosphatase Human genes 0.000 abstract 1
- 108010051457 Acid Phosphatase Proteins 0.000 abstract 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 abstract 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 abstract 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 102000004420 Creatine Kinase Human genes 0.000 abstract 1
- 108010042126 Creatine kinase Proteins 0.000 abstract 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 229910001425 magnesium ion Inorganic materials 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- -1 sulphate ions Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
1480089 Diluent composition for diagnostic tests E I DU PONT DE NEMOURS & CO 28 Nov 1974 [29 Nov 1973] 51606/74 Heading G1B [ Also in Division C3] A liquid composition suitable for use as a diluent for a biologically active material e.g. in the diagnostic measurement of enzyme activity, comprises 4À5 to 8À0 g/dl of a bovine albumin 95- 145 meq/l of sodium ions, 90-112 meq/l of chloride ions, 1-4 mg/dl of magnesium ions, 7- 12 mg/dl of calcium ions, 3-5À5 meq/l of potassium ions, up to 4 mg/l of zinc ions, 2-6 mg/dl of phosphorus as phosphate ions and up to 4 mg/dl of sulphur as sulphate ions, in de-ionized water. The pH is typically 6À5-7À5, osmolarity 190-300 milliosmoles, viscosity 1À2-2À0 centipoise and ionic strength 0À11-0À14 Á. The composition may be stored in the form of porous spheres of diameter not exceeding 1 mm and pore volume of at least 90%, which spheres are produced by spraying the liquid composition into boiling dichlorodifluoromethane at -25‹C and freeze-drying the frozen droplets. The porous spheres are dissolved in de-ionized water prior to use. Examples are directed to the comparison of acid or alkaline phosphatase and creatine phosphokinase activities when measured in undiluted human serum and human serum diluted with distilled water, saline solution or the liquid composition of the invention.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41997473A | 1973-11-29 | 1973-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1480089A true GB1480089A (en) | 1977-07-20 |
Family
ID=23664542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5160674A Expired GB1480089A (en) | 1973-11-29 | 1974-11-28 | Diluent composition for biologically active materials |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5082282A (en) |
| DE (1) | DE2456628A1 (en) |
| FR (1) | FR2253074B1 (en) |
| GB (1) | GB1480089A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110159565A1 (en) * | 2009-12-31 | 2011-06-30 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55156589A (en) * | 1979-05-25 | 1980-12-05 | Baiorisaac Center:Kk | Enzymatic treatment of water-insoluble substrate |
| NL8500266A (en) * | 1985-01-31 | 1986-08-18 | Stichting Gastransport | CALIBRATION SOLUTION FOR ION-SELECTIVE ELECTRODES, DRY MATERIAL FOR MAKING IT OUT, METHOD FOR PREPARING THE SAME, AND USE THEREOF. |
| US5227305A (en) * | 1988-05-13 | 1993-07-13 | Instrumentation Laboratory Spa | Buffer solution systems for standardizing pH analyzers and electrolytes |
-
1974
- 1974-11-27 JP JP13566574A patent/JPS5082282A/ja active Pending
- 1974-11-28 GB GB5160674A patent/GB1480089A/en not_active Expired
- 1974-11-28 FR FR7438999A patent/FR2253074B1/fr not_active Expired
- 1974-11-29 DE DE19742456628 patent/DE2456628A1/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110159565A1 (en) * | 2009-12-31 | 2011-06-30 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof |
| US8753858B2 (en) * | 2009-12-31 | 2014-06-17 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2253074B1 (en) | 1978-09-22 |
| FR2253074A1 (en) | 1975-06-27 |
| JPS5082282A (en) | 1975-07-03 |
| DE2456628A1 (en) | 1975-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |