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GB1473819A - Derivatives of imidazo 1,2-a pyridine - Google Patents

Derivatives of imidazo 1,2-a pyridine

Info

Publication number
GB1473819A
GB1473819A GB337176A GB337176A GB1473819A GB 1473819 A GB1473819 A GB 1473819A GB 337176 A GB337176 A GB 337176A GB 337176 A GB337176 A GB 337176A GB 1473819 A GB1473819 A GB 1473819A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
pyridine
compounds
haloketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB337176A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antonio Gallardo SA
Original Assignee
Antonio Gallardo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Gallardo SA filed Critical Antonio Gallardo SA
Priority to GB337176A priority Critical patent/GB1473819A/en
Priority to ES454823A priority patent/ES454823A1/en
Priority to ES454824A priority patent/ES454824A1/en
Priority to DE19772702790 priority patent/DE2702790A1/en
Priority to FR7702785A priority patent/FR2339612A1/en
Priority to JP861277A priority patent/JPS52116494A/en
Publication of GB1473819A publication Critical patent/GB1473819A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1473819 Imidazo[1,2-a]pyridine derivatives ANTONIO GALLARDO SA 28 Jan 1976 03371/76 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein R is H or C 1-6 alkyl; R<SP>1</SP> is H, halogen, amino, nitro, or C 1-6 alkyl, alkoxy or alkylsulphonyl; and R<SP>2</SP> is C 1-6 alkyl (optionally substituted by 1 or more C 1-6 alkoxy radicals). The compounds are prepared by reacting (1) an R-substituted 2-aminopyridine with the alpha-haloketone or (2) an R-substituted pyridine with the said alpha-haloketone to give a substituted 1:phenacylpyridinium halide, of which the oxime is formed and cyclized in situ. Therapeutic compositions having antiinflammatory, analgesic, antipyretic, antiulcer, anticonvulsant, spasmogenic, spasmolytic and hypertensive activity, and said to be especially useful for treating inflammatory conditions of the gastro-intestinal tract, comprise compounds of the above formula. They may be administered orally, parenterally, rectally or topically.
GB337176A 1976-01-28 1976-01-28 Derivatives of imidazo 1,2-a pyridine Expired GB1473819A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB337176A GB1473819A (en) 1976-01-28 1976-01-28 Derivatives of imidazo 1,2-a pyridine
ES454823A ES454823A1 (en) 1976-01-28 1977-01-05 Derivatives of imidazo 1,2-a pyridine
ES454824A ES454824A1 (en) 1976-01-28 1977-01-05 Derivatives of imidazo 1,2-a pyridine
DE19772702790 DE2702790A1 (en) 1976-01-28 1977-01-24 NEW THERAPEUTICS BASED ON IMIDAZO (1,2-A) PYRIDINE
FR7702785A FR2339612A1 (en) 1976-01-28 1977-01-25 NEW DERIVATIVES OF IMIDAZO 1,2-A PYRIDINE
JP861277A JPS52116494A (en) 1976-01-28 1977-01-28 Imidazo*1*22a*pyridine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB337176A GB1473819A (en) 1976-01-28 1976-01-28 Derivatives of imidazo 1,2-a pyridine

Publications (1)

Publication Number Publication Date
GB1473819A true GB1473819A (en) 1977-05-18

Family

ID=9757057

Family Applications (1)

Application Number Title Priority Date Filing Date
GB337176A Expired GB1473819A (en) 1976-01-28 1976-01-28 Derivatives of imidazo 1,2-a pyridine

Country Status (5)

Country Link
JP (1) JPS52116494A (en)
DE (1) DE2702790A1 (en)
ES (2) ES454823A1 (en)
FR (1) FR2339612A1 (en)
GB (1) GB1473819A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052016A1 (en) * 1980-11-11 1982-05-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
EP0261912A3 (en) * 1986-09-22 1989-09-20 Ortho Pharmaceutical Corporation 2- or 3- Aryl substituted imidazo [1,2-a] pyridines
EP2083009A1 (en) * 2008-01-22 2009-07-29 Grünenthal GmbH Substituted tetrahydroimidazopyridine compounds and their use in medicine
US20100249418A1 (en) * 2007-10-24 2010-09-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
US8569504B2 (en) 2009-06-17 2013-10-29 Ono Pharmaceutical Co., Ltd. Imidazopyridine compound

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154835A (en) * 1977-10-12 1979-05-15 Merck & Co., Inc. Anthelmintic imidazo [1,2-a] pyridines
DE10247271A1 (en) * 2002-10-10 2004-08-26 Grünenthal GmbH Use of new and known 7-(methyl or trifluoromethyl)-imidazo-(1,2-a)-pyridines as nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, neurodegenerative diseases, inflammatory pain, diabetes or cancer

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052016A1 (en) * 1980-11-11 1982-05-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
EP0261912A3 (en) * 1986-09-22 1989-09-20 Ortho Pharmaceutical Corporation 2- or 3- Aryl substituted imidazo [1,2-a] pyridines
US20100249418A1 (en) * 2007-10-24 2010-09-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2083009A1 (en) * 2008-01-22 2009-07-29 Grünenthal GmbH Substituted tetrahydroimidazopyridine compounds and their use in medicine
WO2009092565A1 (en) * 2008-01-22 2009-07-30 Grünenthal GmbH Substituted tetrahydroimidazopyridine compounds and the use thereof in pharmaceuticals
US8288424B2 (en) 2008-01-22 2012-10-16 Gruenenthal Gmbh Substituted tetrahydroimidazopyridine compounds and the use thereof in the treatment of pain and other conditions
US8569504B2 (en) 2009-06-17 2013-10-29 Ono Pharmaceutical Co., Ltd. Imidazopyridine compound

Also Published As

Publication number Publication date
ES454823A1 (en) 1978-01-01
ES454824A1 (en) 1978-01-01
JPS52116494A (en) 1977-09-29
DE2702790A1 (en) 1977-08-04
FR2339612A1 (en) 1977-08-26

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee