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GB1469575A - Preparation of 16,17-cyclic acetals and ketals of 9alpha-halo steroids - Google Patents

Preparation of 16,17-cyclic acetals and ketals of 9alpha-halo steroids

Info

Publication number
GB1469575A
GB1469575A GB4305974A GB4305974A GB1469575A GB 1469575 A GB1469575 A GB 1469575A GB 4305974 A GB4305974 A GB 4305974A GB 4305974 A GB4305974 A GB 4305974A GB 1469575 A GB1469575 A GB 1469575A
Authority
GB
United Kingdom
Prior art keywords
ketals
cyclic acetals
steroids
halo
9alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4305974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lark SpA
Original Assignee
Lark SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lark SpA filed Critical Lark SpA
Publication of GB1469575A publication Critical patent/GB1469575A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1469575 16,17-Cyclic acetals and ketals of 9α - halo - 11#,16α,17α - trihydroxy - steroids LARK SpA 25 Feb 1975 [17 May 1974] 43059/74 Heading C2U 16,17-Cyclic acetals and ketals of 9α-halo- 11#,16α,17α-trihydroxy-steroids of the pregnane series are prepared by treating corresponding 9#,11# - epoxy - 16α,17α - dihydroxysteroids with a minimum quantity of aqueous hydrogen halide as long as this quantity is not below the amount stoichiometrically required for the hydrohalogenation reaction in the presence of the necessary quantity of the selected aldehyde or ketone at - 15‹ to + 20‹ C. and in the absence of other organic diluents.
GB4305974A 1974-05-17 1975-02-25 Preparation of 16,17-cyclic acetals and ketals of 9alpha-halo steroids Expired GB1469575A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2286674 1974-05-17

Publications (1)

Publication Number Publication Date
GB1469575A true GB1469575A (en) 1977-04-06

Family

ID=11201335

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4305974A Expired GB1469575A (en) 1974-05-17 1975-02-25 Preparation of 16,17-cyclic acetals and ketals of 9alpha-halo steroids

Country Status (4)

Country Link
JP (1) JPS548675B2 (en)
DE (1) DE2448548A1 (en)
GB (1) GB1469575A (en)
NL (1) NL7412537A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482934A (en) * 1990-09-07 1996-01-09 Especialidades Latinas Medicamentos Universales, S.A. (Elmu, S.A.) Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions
EP0875516A3 (en) * 1997-04-30 2000-04-12 Farmabios S.r.l. Process for the preparation of 16,17 acetals of pregnane derivatives with control of the epimeric distribution at the C-22 position
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
EP1275656A1 (en) * 2001-07-11 2003-01-15 Genchem Pharma Limited Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
EP2108653A1 (en) * 2008-04-11 2009-10-14 INDUSTRIALE CHIMICA S.r.l. Process for preparing budesonide
CN101348516B (en) * 2008-09-08 2010-08-18 天津太平洋化学制药有限公司 Refining process of triamcinolone acetonide raw medicine
CN106749493A (en) * 2017-01-09 2017-05-31 河南利华制药有限公司 A kind of preparation technology of Halcinonide intermediate
CN106905406A (en) * 2017-01-09 2017-06-30 河南利华制药有限公司 A kind of preparation technology of Triamcinolone acetonide

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221786A (en) * 1978-06-20 1980-09-09 Ciba-Geigy Corporation Novel halogenopregnadienes and process for the manufacture thereof
DE102005009194B4 (en) * 2005-03-01 2006-12-14 Hpp-Hommel Pharmaceuticals Production Gmbh Process for the preparation of polymorphically stable triamcinolone acetonide

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482934A (en) * 1990-09-07 1996-01-09 Especialidades Latinas Medicamentos Universales, S.A. (Elmu, S.A.) Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions
EP0875516A3 (en) * 1997-04-30 2000-04-12 Farmabios S.r.l. Process for the preparation of 16,17 acetals of pregnane derivatives with control of the epimeric distribution at the C-22 position
US6169178B1 (en) 1997-04-30 2001-01-02 Farmabios S.R.L. Process for the preparation of 16,17 acetals of pregnane derivatives with control of the epimeric distribution at the C-22 position
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
EP1275656A1 (en) * 2001-07-11 2003-01-15 Genchem Pharma Limited Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
EP2108653A1 (en) * 2008-04-11 2009-10-14 INDUSTRIALE CHIMICA S.r.l. Process for preparing budesonide
US8119793B2 (en) 2008-04-11 2012-02-21 Industriale Chimica S.R.L. Process for preparing budesonide
CN101348516B (en) * 2008-09-08 2010-08-18 天津太平洋化学制药有限公司 Refining process of triamcinolone acetonide raw medicine
CN106749493A (en) * 2017-01-09 2017-05-31 河南利华制药有限公司 A kind of preparation technology of Halcinonide intermediate
CN106905406A (en) * 2017-01-09 2017-06-30 河南利华制药有限公司 A kind of preparation technology of Triamcinolone acetonide

Also Published As

Publication number Publication date
NL7412537A (en) 1975-11-19
JPS50149661A (en) 1975-11-29
DE2448548A1 (en) 1975-11-27
JPS548675B2 (en) 1979-04-17

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee