GB1462356A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1462356A GB1462356A GB3283373A GB3283373A GB1462356A GB 1462356 A GB1462356 A GB 1462356A GB 3283373 A GB3283373 A GB 3283373A GB 3283373 A GB3283373 A GB 3283373A GB 1462356 A GB1462356 A GB 1462356A
- Authority
- GB
- United Kingdom
- Prior art keywords
- particles
- antibiotic
- july
- cross
- benzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 5
- 230000003115 biocidal effect Effects 0.000 abstract 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000005633 phthalidyl group Chemical group 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 229920000193 polymethacrylate Polymers 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1462356 Antibiotic preparations BEECHAM GROUP Ltd 12 July 1974 [10 July 1973] 32833/73 Heading A5B Antibiotic particles comprise (a) 20-70 weight % of a semi-synthetic penicillin or cephalosporin containing a basic group absorbed on (b) 30-80% of pharmaceutially acceptable, benzene-insoluble, acidic cationexchange particles, which particles are resistant to enzmatic degradation, contain not more than 4% cross-linking and have a particle size between 20 and 250 microns. The antibiotic may be the phthalidyl or pivaloxymethyl ester of ampicillin. The resin may be a carboxylated polyacrylate or polymethacrylate or a sulphonylated polystyrene cross-linked with divinyl benzene. The particles may be combined with another beta-lactam antibiotic and an excipient. They may be mixed with water to provide a syrup or made into tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3283373A GB1462356A (en) | 1973-07-10 | 1973-07-10 | Pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3283373A GB1462356A (en) | 1973-07-10 | 1973-07-10 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1462356A true GB1462356A (en) | 1977-01-26 |
Family
ID=10344680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3283373A Expired GB1462356A (en) | 1973-07-10 | 1973-07-10 | Pharmaceutical compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1462356A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02111719A (en) * | 1988-05-11 | 1990-04-24 | Glaxo Group Ltd | drug adsorbate |
| EP0431759A1 (en) * | 1989-11-10 | 1991-06-12 | Glaxo Group Limited | Process for the preparation of a ranitidine resin absorbate |
| WO1994008572A1 (en) * | 1992-10-15 | 1994-04-28 | Alza Corporation | Delayed onset transdermal delivery device |
| EP0527606A3 (en) * | 1991-08-14 | 1994-07-20 | Rohm & Haas | Apparatus and process for measuring release rates of bound solutes from binding compositions |
| EP0622083A1 (en) * | 1993-04-28 | 1994-11-02 | Takeda Chemical Industries, Ltd. | Taste masked solid preparation and its production |
| US5730999A (en) * | 1993-03-27 | 1998-03-24 | Roehm Gmbh Chemische Fabrik | Dermal therapeutic system made of a meltable poly (meth) acrylate |
-
1973
- 1973-07-10 GB GB3283373A patent/GB1462356A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02111719A (en) * | 1988-05-11 | 1990-04-24 | Glaxo Group Ltd | drug adsorbate |
| EP0431759A1 (en) * | 1989-11-10 | 1991-06-12 | Glaxo Group Limited | Process for the preparation of a ranitidine resin absorbate |
| EP0527606A3 (en) * | 1991-08-14 | 1994-07-20 | Rohm & Haas | Apparatus and process for measuring release rates of bound solutes from binding compositions |
| WO1994008572A1 (en) * | 1992-10-15 | 1994-04-28 | Alza Corporation | Delayed onset transdermal delivery device |
| US5730999A (en) * | 1993-03-27 | 1998-03-24 | Roehm Gmbh Chemische Fabrik | Dermal therapeutic system made of a meltable poly (meth) acrylate |
| EP0622083A1 (en) * | 1993-04-28 | 1994-11-02 | Takeda Chemical Industries, Ltd. | Taste masked solid preparation and its production |
| US5464612A (en) * | 1993-04-28 | 1995-11-07 | Takeda Chemical Industries, Ltd. | Solid preparation comprising ion exchanger and active agent |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |