GB1461528A - Removal of albumin from aqueous fluids and compounds therefor - Google Patents
Removal of albumin from aqueous fluids and compounds thereforInfo
- Publication number
- GB1461528A GB1461528A GB3934574A GB3934574A GB1461528A GB 1461528 A GB1461528 A GB 1461528A GB 3934574 A GB3934574 A GB 3934574A GB 3934574 A GB3934574 A GB 3934574A GB 1461528 A GB1461528 A GB 1461528A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cibacron
- albumin
- procion
- blue
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000009027 Albumins Human genes 0.000 title abstract 5
- 108010088751 Albumins Proteins 0.000 title abstract 5
- 239000012530 fluid Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- RTLULCVBFCRQKI-UHFFFAOYSA-N 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid Chemical compound C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S(O)(=O)=O)C=C1NC(C=1)=CC=C(S(O)(=O)=O)C=1NC1=NC(Cl)=NC(Cl)=N1 RTLULCVBFCRQKI-UHFFFAOYSA-N 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 229920002307 Dextran Polymers 0.000 abstract 2
- POJOORKDYOPQLS-UHFFFAOYSA-L barium(2+) 5-chloro-2-[(2-hydroxynaphthalen-1-yl)diazenyl]-4-methylbenzenesulfonate Chemical compound [Ba+2].C1=C(Cl)C(C)=CC(N=NC=2C3=CC=CC=C3C=CC=2O)=C1S([O-])(=O)=O.C1=C(Cl)C(C)=CC(N=NC=2C3=CC=CC=C3C=CC=2O)=C1S([O-])(=O)=O POJOORKDYOPQLS-UHFFFAOYSA-L 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 229920000178 Acrylic resin Polymers 0.000 abstract 1
- 239000004925 Acrylic resin Substances 0.000 abstract 1
- 229920000936 Agarose Polymers 0.000 abstract 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 abstract 1
- -1 Cibacron brown Chemical compound 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002156 adsorbate Substances 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GTRGJJDVSJFNTE-UHFFFAOYSA-N chembl2009633 Chemical compound OC1=CC=C2C=C(S(O)(=O)=O)C=CC2=C1N=NC1=CC=CC=C1 GTRGJJDVSJFNTE-UHFFFAOYSA-N 0.000 abstract 1
- YKCWQPZFAFZLBI-UHFFFAOYSA-N cibacron blue Chemical compound C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S(O)(=O)=O)C=C1NC(C=C1S(O)(=O)=O)=CC=C1NC(N=1)=NC(Cl)=NC=1NC1=CC=CC=C1S(O)(=O)=O YKCWQPZFAFZLBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920002401 polyacrylamide Polymers 0.000 abstract 1
- 239000000985 reactive dye Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
- C08B37/0039—Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
- C09B62/02—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring
- C09B62/04—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to a triazine ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
1461528 Removing albumin from aqueous fluids; dextran-dye conjugates RESEARCH CORP 9 Sept 1974 [10 Sept 1973] 39345/74 Headings C3H and C3U A method of removing albumin from substantially cell-free aqueous fluids comprises (a) suspending a composition of general formula [SP] x -[CRD] where CRD is the residue of a colour reactive dye of the Formula I wherein R 3 is alkyl, phenyl, alkoxyphenyl, alkyl phenyl, or hydrogen, R 1 is hydrogen, an alkali metal ion or an alkaline earth metal ion, R 2 is halide or -o-dextran, Z 1 is [-H] 2 or-CH=CH-CH=CH-, Z 2 is one bond of a nitrogen-nitrogen double bond or a hydrogen atom attached to the nitrogen atom shown only, Q is substituted or unsubstituted aryl where Z 2 is hydrogen or an unsubstituted aryl-N= where Z 2 constitutes a double bond, provided that the substituent groups aforesaid are other than halide or heavy metal (i.e. of groups other than 1 or 2A) and wherein SP is a solid support phase selected from agarose, polyacrylamide, and acrylic resin containing amino groups and x is expressed as a weight ratio of SP to CRD of between 0À8 and 40, in a buffer of at least 0À05 M molarity at a pH of 6À5 to 8À5; (b) contacting said suspension with said albumin containing fluid to provide a suspension having albumin adsorbed upon the solid phase thereof; (c) separating the solid-phase-albumin adsorbate from the aqueous phase. The preferred dyestuffs are Blue Dextran and those dyestuffs identified by the designations Cibacron (Registered Trade Mark) orange, Procion (Registered Trade Mark) brilliant orange, Cibacron brilliant blue, Cibacron blue, Procion blue, Cibacron brilliant red, Procion brilliant red, Cibacron brown, Procion orange brown, Cibacron scarlet, and Procion scarlet. The preferred conjugate has the formula
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39603673A | 1973-09-10 | 1973-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1461528A true GB1461528A (en) | 1977-01-13 |
Family
ID=23565576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3934574A Expired GB1461528A (en) | 1973-09-10 | 1974-09-09 | Removal of albumin from aqueous fluids and compounds therefor |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5126900A (en) |
| CA (1) | CA1034569A (en) |
| CH (1) | CH600782A5 (en) |
| DE (1) | DE2443119A1 (en) |
| FR (1) | FR2243438A1 (en) |
| GB (1) | GB1461528A (en) |
| IL (1) | IL45618A (en) |
| IT (1) | IT1021253B (en) |
| NL (1) | NL7411909A (en) |
| SE (1) | SE7411373L (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2267502A (en) * | 1992-05-28 | 1993-12-08 | Aligena Ag | Immobilized buffered gels and membranes of hydroxy groups containing polymers |
| WO2006108760A3 (en) * | 2005-04-08 | 2007-07-19 | Ciba Sc Holding Ag | Adsorbents comprising anthraquinone dye-ligands for the separation of biological materials |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2351665A1 (en) * | 1976-05-21 | 1977-12-16 | Elf Aquitaine | PROCESS FOR PURIFYING PREPARATIONS INCLUDING IN PARTICULAR AN INTERFERON ACTIVITY, PURIFIED PREPARATIONS THUS OBTAINED AND THEIR APPLICATION AS A MEDICINAL PRODUCT |
| US4043997A (en) * | 1976-05-28 | 1977-08-23 | Cutter Laboratories, Inc. | Method for isolating albumin using insoluble supports coupled to a dye |
| DE2709094C2 (en) * | 1977-03-02 | 1984-11-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Adsorbent for affinity-specific separation of nucleic acids, process for its preparation and its use |
| JPS53128602A (en) * | 1977-04-15 | 1978-11-09 | Mitsui Eng & Shipbuild Co Ltd | Heat recovery device of high-temperature coke |
| JPS63199149U (en) * | 1987-06-06 | 1988-12-21 | ||
| JPS6410057U (en) * | 1987-07-07 | 1989-01-19 | ||
| US7019129B1 (en) * | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
| WO2009124150A2 (en) | 2008-04-01 | 2009-10-08 | Biosearch Technologies, Inc. | Stabilized nucleic acid dark quencher-fluorophore probes |
-
1974
- 1974-09-09 DE DE2443119A patent/DE2443119A1/en active Pending
- 1974-09-09 NL NL7411909A patent/NL7411909A/en not_active Application Discontinuation
- 1974-09-09 CA CA208,689A patent/CA1034569A/en not_active Expired
- 1974-09-09 SE SE7411373A patent/SE7411373L/xx unknown
- 1974-09-09 CH CH1222074A patent/CH600782A5/xx not_active IP Right Cessation
- 1974-09-09 JP JP49103780A patent/JPS5126900A/en active Pending
- 1974-09-09 GB GB3934574A patent/GB1461528A/en not_active Expired
- 1974-09-09 IL IL45618A patent/IL45618A/en unknown
- 1974-09-10 IT IT27140/74A patent/IT1021253B/en active
- 1974-09-10 FR FR7430595A patent/FR2243438A1/fr not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2267502A (en) * | 1992-05-28 | 1993-12-08 | Aligena Ag | Immobilized buffered gels and membranes of hydroxy groups containing polymers |
| US5430099A (en) * | 1992-05-28 | 1995-07-04 | Aligena Ag | Immobilized buffered gels and membranes of hydroxy groups containing polymers |
| US5597863A (en) * | 1992-05-28 | 1997-01-28 | Aligena Ag | Immobilized buffered gels and membranes of hydroxy groups containing polymers |
| US5599506A (en) * | 1992-05-28 | 1997-02-04 | Aligena Ag | Immobilized buffered gels and membranes of hydroxy groups containing polymers |
| WO2006108760A3 (en) * | 2005-04-08 | 2007-07-19 | Ciba Sc Holding Ag | Adsorbents comprising anthraquinone dye-ligands for the separation of biological materials |
| US8227599B2 (en) | 2005-04-08 | 2012-07-24 | Basf Se | Adsorbents comprising anthraquinone dye-ligends for the separation of biological materials |
Also Published As
| Publication number | Publication date |
|---|---|
| CH600782A5 (en) | 1978-06-30 |
| CA1034569A (en) | 1978-07-11 |
| JPS5126900A (en) | 1976-03-05 |
| FR2243438A1 (en) | 1975-04-04 |
| DE2443119A1 (en) | 1975-03-13 |
| IL45618A (en) | 1978-06-15 |
| NL7411909A (en) | 1975-03-12 |
| IT1021253B (en) | 1978-01-30 |
| SE7411373L (en) | 1975-03-11 |
| IL45618A0 (en) | 1975-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |