GB1460019A - 6,7-diaza 3,2,2-bicyclonon-3-yl derivatives - Google Patents
6,7-diaza 3,2,2-bicyclonon-3-yl derivativesInfo
- Publication number
- GB1460019A GB1460019A GB2601773A GB2601773A GB1460019A GB 1460019 A GB1460019 A GB 1460019A GB 2601773 A GB2601773 A GB 2601773A GB 2601773 A GB2601773 A GB 2601773A GB 1460019 A GB1460019 A GB 1460019A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- derivatives
- stereoisomers
- ketones
- alcohols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 acetyltropoyl Chemical group 0.000 abstract 8
- 150000001298 alcohols Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- OXTNCQMOKLOUAM-UHFFFAOYSA-N 3-Oxoglutaric acid Chemical class OC(=O)CC(=O)CC(O)=O OXTNCQMOKLOUAM-UHFFFAOYSA-N 0.000 abstract 1
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940124575 antispasmodic agent Drugs 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- WLNWKZXPHXIQKT-UHFFFAOYSA-N cyclohepta-2,6-dien-1-one Chemical compound O=C1C=CCCC=C1 WLNWKZXPHXIQKT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1460019 Derivatives of 6,7-diaza-[3,2,2]- bicyclononane ASSIA CHEMICAL LABORATORIES Ltd 21 May 1974 [31 May 1973] 26017/73 Heading C2C The invention comprises compounds of formula including the optical isomers and other stereoisomers, and the physiologically active and pharmaceutically acceptable salts, wherein R 1 is O = or R being H, tropoyl, acetyltropoyl, atropoyl, benzoyl, p-aminobenzoyl, benziloyl, mandeloyl, cinnamoyl, propylvaleroyl, diarylacryloyl or benzhydryl; and R 2 , R 3 are each H, C 1-7 alkyl, C 2-4 alkenyl, C 3-7 cycloalkyl, carboxy-C 1-4 - alkyl, aryl-C 1-4 -alkyl, #-alkoxycarbonylethyl (possibly α-Ph-substituted), or C 1-4 alkyl substituted by mono- or dialkylamino, piperidino, morpholino or pyrrolidino. In examples, the ketones are prepared by reacting R 2 NHNHR 3 with cyclohepta-2,6-dienone or with succinaldehyde + an acetonedicarboxylic acid derivative, and may be reduced to the alcohols, which in turn may be esterified. Stereoisomers of the alcohols (or their derivatives) may be selectively formed by choice of reducing agent and may be interconverted. Therapeutic compositions which may have atropine-like activity and may be antispasmodics, anticholinergics and histamine antagonists, comprise compounds of the above formula (other than the ketones). Forms suitable for oral, parenteral, rectal and topical administration are mentioned.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2601773A GB1460019A (en) | 1973-05-31 | 1973-05-31 | 6,7-diaza 3,2,2-bicyclonon-3-yl derivatives |
| IL44765A IL44765A (en) | 1973-05-31 | 1974-05-05 | 3-substituted 6,7-diaza-(3,2,2)-bicyclononane derivatives |
| ZA00743184A ZA743184B (en) | 1973-05-31 | 1974-05-17 | '3-substituted 8,9-diaza<3,2,2>-bicycloan derivatives |
| AU69392/74A AU487415B2 (en) | 1973-05-31 | 1974-05-27 | 3-substituted 8, 9-diaza [3,2,2] - bicyclonan derivatives |
| FR7418639A FR2241304B1 (en) | 1973-05-31 | 1974-05-29 | |
| DE19742426105 DE2426105A1 (en) | 1973-05-31 | 1974-05-29 | 8,9 DIAZA ANGULAR CLAMP ON 3,2,2 ANGLE CLAMP FOR BICYCLONONANE DERIVATIVES, THEIR SALT, METHOD FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2601773A GB1460019A (en) | 1973-05-31 | 1973-05-31 | 6,7-diaza 3,2,2-bicyclonon-3-yl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1460019A true GB1460019A (en) | 1976-12-31 |
Family
ID=10237053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2601773A Expired GB1460019A (en) | 1973-05-31 | 1973-05-31 | 6,7-diaza 3,2,2-bicyclonon-3-yl derivatives |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE2426105A1 (en) |
| FR (1) | FR2241304B1 (en) |
| GB (1) | GB1460019A (en) |
| IL (1) | IL44765A (en) |
| ZA (1) | ZA743184B (en) |
-
1973
- 1973-05-31 GB GB2601773A patent/GB1460019A/en not_active Expired
-
1974
- 1974-05-05 IL IL44765A patent/IL44765A/en unknown
- 1974-05-17 ZA ZA00743184A patent/ZA743184B/en unknown
- 1974-05-29 FR FR7418639A patent/FR2241304B1/fr not_active Expired
- 1974-05-29 DE DE19742426105 patent/DE2426105A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2426105A1 (en) | 1975-01-02 |
| FR2241304A1 (en) | 1975-03-21 |
| ZA743184B (en) | 1975-05-28 |
| AU6939274A (en) | 1975-11-27 |
| IL44765A (en) | 1977-07-31 |
| FR2241304B1 (en) | 1977-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT49612A (en) | Process for producing new 3-alkenyl-1-azabicyclo/3.2.0/ hept-2-ene-2-carboxylic acid derivatives and pharmaceutical compositions comprising same | |
| DE68917023D1 (en) | 3-pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds. | |
| IT1229570B (en) | FLUORATED DERIVATIVES OF BILIARY ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| AU538424B2 (en) | Piperazino phenylindane | |
| IT1223313B (en) | BILIARY ACID DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| ATE83147T1 (en) | ANTI-ALLERGIC 2(HETEROCYCLYLALKYL)IMIDAZOPYRIDINE AND 2(HETEROCYCLYLALKYL) PURINE. | |
| ATE13297T1 (en) | PIPERIDYLID DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM. | |
| DK157785D0 (en) | 1,5-BENZOTHIAZEPINE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION | |
| ES8701752A1 (en) | Benzimidazoles. | |
| GB1460019A (en) | 6,7-diaza 3,2,2-bicyclonon-3-yl derivatives | |
| DE3682225D1 (en) | CARBAPEN DERIVATIVES, THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. | |
| AU658175B2 (en) | Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients | |
| JPS56103183A (en) | Pyridazine derivative and its application to medicine | |
| ES8206537A1 (en) | Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them. | |
| GB1152788A (en) | 1,8-Naphthyridine Derivatives and Intermediates therefor | |
| GB1163921A (en) | Azadibenzocycloheptene Derivatives | |
| GB1109588A (en) | Improvements in or relating to nitrothiophene compounds | |
| GB1210106A (en) | Derivatives of 1,2,3,4-tetrahydrobenzothieno [2,3-c]pyridine and of 1,2,3,4-tetrahydro-5h-benzothieno[2,3-c]azepine | |
| GB1218590A (en) | N-substituted piperidine spiro compounds | |
| ES472208A1 (en) | Benzimidazole-2 derivatives, their preparation and their use for the preparation of medicaments. | |
| ES8207176A1 (en) | Naphthyridine derivatives | |
| IL43236A (en) | 15alpha,16alpha-methylene-19-nor-delta4-pregnene-3,20-diones | |
| GB1418831A (en) | Reserpine derivatives | |
| GB1197985A (en) | Improvements in or relating to Piperidones | |
| FR2370473A1 (en) | Azetidine compsn. for treating psoriasis - contg. 3-hydrocarbyl-sulphonyloxy-azetidine derivs. formulated e.g. as topical compsn. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 416 | Proceeding under section 16 patents act 1949 | ||
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |