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GB1459571A - Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus - Google Patents

Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus

Info

Publication number
GB1459571A
GB1459571A GB3975374A GB3975374A GB1459571A GB 1459571 A GB1459571 A GB 1459571A GB 3975374 A GB3975374 A GB 3975374A GB 3975374 A GB3975374 A GB 3975374A GB 1459571 A GB1459571 A GB 1459571A
Authority
GB
United Kingdom
Prior art keywords
thiophene
therapeutic agents
sulphonamide derivatives
orienting apparatus
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3975374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER Ltd
Original Assignee
PFIZER Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER Ltd filed Critical PFIZER Ltd
Priority to GB3975374A priority Critical patent/GB1459571A/en
Publication of GB1459571A publication Critical patent/GB1459571A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1459571 Thiophene-2-sulphonamide derivatives PFIZER Ltd 10 Sept 1975 [12 Sept 1974] 39753/74 Heading C2C The invention comprises compounds of the Formula I where Ar represents a mono- or bi-cyclic aromatic group, optionally substituted; n is 0, 1 or 2 and R represents a hydrogen or halogen atom, or a C 1 to C 6 alkyl, C 1 to C 6 alkoxy, hydroxyl, nitro, amino or mono- or dialkylamino group; and the alkali metal or acid addition salts of such compounds. The compounds of Formula I are used as therapeutic agents.
GB3975374A 1974-09-12 1974-09-12 Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus Expired GB1459571A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3975374A GB1459571A (en) 1974-09-12 1974-09-12 Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3975374A GB1459571A (en) 1974-09-12 1974-09-12 Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus

Publications (1)

Publication Number Publication Date
GB1459571A true GB1459571A (en) 1976-12-22

Family

ID=10411298

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3975374A Expired GB1459571A (en) 1974-09-12 1974-09-12 Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus

Country Status (1)

Country Link
GB (1) GB1459571A (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042731A1 (en) * 1980-06-21 1981-12-30 Pfizer Limited Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them
US4477466A (en) * 1983-05-23 1984-10-16 Merck & Co., Inc. Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure
US4542152A (en) * 1983-05-23 1985-09-17 Merck & Co., Inc. 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
EP0182691A1 (en) * 1984-11-02 1986-05-28 Merck & Co. Inc. Substituted thiophene-2-sulfonamides and their preparation
EP0130109A3 (en) * 1983-06-20 1986-11-26 Merck & Co. Inc. Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
EP0228237A1 (en) * 1985-12-24 1987-07-08 Merck & Co. Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4721794A (en) * 1984-11-02 1988-01-26 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4788192A (en) * 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
EP0295049A3 (en) * 1987-06-08 1989-03-08 Merck & Co. Inc. Thiophene sulfonamide antiglaucoma agents
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
EP0479480A3 (en) * 1990-10-01 1992-04-22 Merck & Co. Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents
US8680139B2 (en) 2009-04-01 2014-03-25 Progenra Anti-neoplastic compounds, compositions and methods
US11364300B2 (en) 2018-05-01 2022-06-21 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
US11596633B2 (en) 2017-09-07 2023-03-07 Revolution Medicines, Inc. SHP2 inhibitor compositions and methods for treating cancer
US11661401B2 (en) 2016-07-12 2023-05-30 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors
US11673896B2 (en) 2017-01-23 2023-06-13 Revolution Medicines, Inc. Pyridine compounds as allosteric SHP2 inhibitors
US11673901B2 (en) 2017-12-15 2023-06-13 Revolution Medicines, Inc. Polycyclic compounds as allosteric SHP2 inhibitors
US11685749B2 (en) 2018-05-01 2023-06-27 Revolution Medicines, Inc. C26-linked rapamycin analogs as mTOR inhibitors
US11702411B2 (en) 2017-10-12 2023-07-18 Revolution Medicines, Inc. Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
US11739093B2 (en) 2017-01-23 2023-08-29 Revolution Medicines, Inc. Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
US12121522B2 (en) 2022-05-25 2024-10-22 Revolution Medicines, Inc. Methods of treating cancer with an mTOR inhibitor
US12544448B2 (en) 2024-04-30 2026-02-10 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042731A1 (en) * 1980-06-21 1981-12-30 Pfizer Limited Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them
US4477466A (en) * 1983-05-23 1984-10-16 Merck & Co., Inc. Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure
US4542152A (en) * 1983-05-23 1985-09-17 Merck & Co., Inc. 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4788192A (en) * 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
EP0130109A3 (en) * 1983-06-20 1986-11-26 Merck & Co. Inc. Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
EP0182691A1 (en) * 1984-11-02 1986-05-28 Merck & Co. Inc. Substituted thiophene-2-sulfonamides and their preparation
US4721794A (en) * 1984-11-02 1988-01-26 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
EP0228237A1 (en) * 1985-12-24 1987-07-08 Merck & Co. Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
EP0295049A3 (en) * 1987-06-08 1989-03-08 Merck & Co. Inc. Thiophene sulfonamide antiglaucoma agents
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
EP0479480A3 (en) * 1990-10-01 1992-04-22 Merck & Co. Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents
US8680139B2 (en) 2009-04-01 2014-03-25 Progenra Anti-neoplastic compounds, compositions and methods
US11661401B2 (en) 2016-07-12 2023-05-30 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors
US11739093B2 (en) 2017-01-23 2023-08-29 Revolution Medicines, Inc. Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
US11673896B2 (en) 2017-01-23 2023-06-13 Revolution Medicines, Inc. Pyridine compounds as allosteric SHP2 inhibitors
US12365688B2 (en) 2017-01-23 2025-07-22 Revolution Medicines, Inc. Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
US11596633B2 (en) 2017-09-07 2023-03-07 Revolution Medicines, Inc. SHP2 inhibitor compositions and methods for treating cancer
US11702411B2 (en) 2017-10-12 2023-07-18 Revolution Medicines, Inc. Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
US11673901B2 (en) 2017-12-15 2023-06-13 Revolution Medicines, Inc. Polycyclic compounds as allosteric SHP2 inhibitors
US11364300B2 (en) 2018-05-01 2022-06-21 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
US11685749B2 (en) 2018-05-01 2023-06-27 Revolution Medicines, Inc. C26-linked rapamycin analogs as mTOR inhibitors
US12048749B2 (en) 2018-05-01 2024-07-30 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
US12187746B2 (en) 2018-05-01 2025-01-07 Revolution Medicines, Inc. C26-linked rapamycin analogs as mTOR inhibitors
US12121522B2 (en) 2022-05-25 2024-10-22 Revolution Medicines, Inc. Methods of treating cancer with an mTOR inhibitor
US12539305B2 (en) 2022-05-25 2026-02-03 Revolution Medicines, Inc. Methods of treating cancer with an mTOR inhibitor
US12544448B2 (en) 2024-04-30 2026-02-10 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee