[go: up one dir, main page]

GB1457911A - Guanyl-hydrazones - Google Patents

Guanyl-hydrazones

Info

Publication number
GB1457911A
GB1457911A GB822574A GB822574A GB1457911A GB 1457911 A GB1457911 A GB 1457911A GB 822574 A GB822574 A GB 822574A GB 822574 A GB822574 A GB 822574A GB 1457911 A GB1457911 A GB 1457911A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
reacting
aryl
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB822574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of GB1457911A publication Critical patent/GB1457911A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

1457911 Amidinohydrazones BEIERSDORF AG 22 Feb 1974 [24 Feb 1973] 8225/74 Heading C2C Novel amidinoguanidines of the formula and acid addition salts thereof, wherein R 1 is C 1-4 alkyl; R 2 is aryl, alkylamino, arylamino, aralkylamino or aryloxyalkylamino, or a group of the formula R 5 R 6 -N-R 4 -, wherein R 5 is H or alkyl and R 6 is alkyl or R 5 and R 6 together with N atom to which they are attached form a 5- to 7-membered saturated heterocyclic ring, and R 4 is alkylene, and R3 is H, alkyl, aryl, aralkyl or aryloxyalkyl (the term aryl including heteroaryl) are prepared by reacting the appropriate ketones with aminoguanidines of the formula p-Butyrylphenylurea is obtained by reacting p-aminobutyrophenone with methyl isocyanate. 4<SP>1</SP> - Acetyl - 2 - diethylaminoacetonilide is obtained by reacting diethylamine with 4<SP>1</SP>- acetyl-2-chloroacetanilide. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above novel compounds or acid addition salts thereof together with pharmaceutically acceptable carriers or diluents.
GB822574A 1973-02-24 1974-02-22 Guanyl-hydrazones Expired GB1457911A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732309260 DE2309260A1 (en) 1973-02-24 1973-02-24 SUBSTITUTED GUANYLHYDRAZONES FROM ALKYLARYL KETONES

Publications (1)

Publication Number Publication Date
GB1457911A true GB1457911A (en) 1976-12-08

Family

ID=5872970

Family Applications (1)

Application Number Title Priority Date Filing Date
GB822574A Expired GB1457911A (en) 1973-02-24 1974-02-22 Guanyl-hydrazones

Country Status (8)

Country Link
JP (1) JPS5024235A (en)
AT (1) AT335468B (en)
BE (1) BE811466A (en)
CA (1) CA1002052A (en)
DE (1) DE2309260A1 (en)
FR (1) FR2218889B1 (en)
GB (1) GB1457911A (en)
NL (1) NL7402335A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971986A (en) * 1988-03-25 1990-11-20 Ciba-Geigy Corporation Arylhydrazones useful as SAMDC inhibitors
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130324A (en) * 1984-03-19 1992-07-14 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971986A (en) * 1988-03-25 1990-11-20 Ciba-Geigy Corporation Arylhydrazones useful as SAMDC inhibitors
US5118709A (en) * 1988-03-25 1992-06-02 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions containing the same
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
US5376685A (en) * 1988-03-25 1994-12-27 Ciba-Geigy Corporation Arylhydrazones using as SAMDC inhibitors
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

Also Published As

Publication number Publication date
FR2218889A1 (en) 1974-09-20
JPS5024235A (en) 1975-03-15
DE2309260A1 (en) 1974-08-29
AT335468B (en) 1977-03-10
CA1002052A (en) 1976-12-21
NL7402335A (en) 1974-08-27
FR2218889B1 (en) 1976-12-03
ATA147174A (en) 1976-07-15
BE811466A (en) 1974-06-17

Similar Documents

Publication Publication Date Title
GB1432576A (en) Substituted phenylacetic acids
GB1505305A (en) Benzcycloamide derivatives
IE812273L (en) Cephalosporin derivatives
GB1511095A (en) Phenylacetic acid derivatives
HK41086A (en) Amine salts of clavulanic acid, methods for their preparation and compositions containing them
ES8302001A1 (en) Cephalosporin derivatives, a process for their preparation and compositions containing them.
GB1355147A (en) Oxoprostanoic acid derivatives
GB1427139A (en) Penicillins
GB1457911A (en) Guanyl-hydrazones
GB1436533A (en) Aryl piperazine derivatives of adenine
DE3267188D1 (en) Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same
GB1436307A (en) Diaromatic o-aminoalkyl-oximes
IE35879B1 (en) Penicillanic acid derivatives
GB1418619A (en) 3,4-dihydro-2-h-naphthalin-1-one-5-oxypropyl-piperazine derivatives
IE39213B1 (en) New pyrazol 5-ones their preparation and their pharmaceutical use
GB1322987A (en) On,n-diacylhydroxylamine derivatives and preparation
GB1361863A (en) Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1156781A (en) New Heterocyclic Compounds
GB1390402A (en) Substituted imidazolecarboxamides
GB1345214A (en) Isoxazoles
GB1327157A (en) N-acyl-piperazinoalkyl-pyrazoles and their preparation
GB1464431A (en) Indolobenzazepine derivatives and a process for the manufacture thereof
GB1514225A (en) Paracetamol derivatives
GB1384523A (en) Oxime derivatives and their preparation
GB1441872A (en) Nitrobenzophenones

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee