GB1457400A - Pharmaceutical compositions containing 2-substituted quinoxa lines - Google Patents
Pharmaceutical compositions containing 2-substituted quinoxa linesInfo
- Publication number
- GB1457400A GB1457400A GB3198676A GB3198676A GB1457400A GB 1457400 A GB1457400 A GB 1457400A GB 3198676 A GB3198676 A GB 3198676A GB 3198676 A GB3198676 A GB 3198676A GB 1457400 A GB1457400 A GB 1457400A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- compositions containing
- alkyl
- quinoxa
- lines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003252 quinoxalines Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 hexafluoro-2- hydroxy-2-propyl Chemical group 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1457400 Anti-inflammatory compositions containing quinoxalines PFIZER Inc 14 Nov 1973 [20. Nov 1972 26 Oct 1973] 31986/76 Divided out of 1457005 Heading A5B [Also in Division C2] Therapeutic compositions having antiinflammatory activity comprise compounds of formula or their pharmaceutically-acceptable acid addition salts, wherein R 2 and R 3 are each hydrogen; lower alkyl, lower alkoxy, hexafluoro-2- hydroxy-2-propyl or chlorine; R, is. lower alkyl lower alkoxy, phenyl, phenoxy or chlorine; and R 8 is amino, lower dialkylamino, lower di(hydroxyalkyl)amino, morpholino, piparidino, piperazino or 4-substituted pipeea.zi.no wherein said substituent is lower, alkyl or lower hyer.,o,- xyalkyl, and a, pharmaceutically acceptable carrier. The ward "lower" signifies 1-4 C atoms. Oral and parenteral routes of administration are mentioned.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30816872A | 1972-11-20 | 1972-11-20 | |
| US41021473A | 1973-10-26 | 1973-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1457400A true GB1457400A (en) | 1976-12-01 |
Family
ID=26976126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3198676A Expired GB1457400A (en) | 1972-11-20 | 1973-11-14 | Pharmaceutical compositions containing 2-substituted quinoxa lines |
| GB5293673A Expired GB1457005A (en) | 1972-11-20 | 1973-11-14 | 2-substituted-3-aminoquinoxalines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5293673A Expired GB1457005A (en) | 1972-11-20 | 1973-11-14 | 2-substituted-3-aminoquinoxalines |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS554100B2 (en) |
| DE (1) | DE2357186A1 (en) |
| FR (1) | FR2206951B1 (en) |
| GB (2) | GB1457400A (en) |
| NL (1) | NL7315808A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI193974A7 (en) * | 1973-07-13 | 1975-01-14 | Merck & Co Inc | |
| DE2730644A1 (en) * | 1977-07-07 | 1979-01-25 | Bayer Ag | FLUORESCENT DYES |
| AU1918299A (en) * | 1998-02-23 | 1999-09-06 | Warner-Lambert Company | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| NZ536664A (en) | 2002-06-19 | 2007-07-27 | Biovitrum Ab | Piperazinylpyrazine derivative compounds, their use and preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2107301A1 (en) * | 1970-02-25 | 1971-09-09 | CIBA Geigy AG, Basel (Schweiz) | New heterocyclic compounds and processes for their preparation |
-
1973
- 1973-11-14 GB GB3198676A patent/GB1457400A/en not_active Expired
- 1973-11-14 GB GB5293673A patent/GB1457005A/en not_active Expired
- 1973-11-16 DE DE2357186A patent/DE2357186A1/en active Pending
- 1973-11-16 JP JP12836473A patent/JPS554100B2/ja not_active Expired
- 1973-11-19 NL NL7315808A patent/NL7315808A/xx not_active Application Discontinuation
- 1973-11-20 FR FR7341265A patent/FR2206951B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1457005A (en) | 1976-12-01 |
| DE2357186A1 (en) | 1974-05-22 |
| NL7315808A (en) | 1974-05-22 |
| FR2206951A1 (en) | 1974-06-14 |
| JPS49133384A (en) | 1974-12-21 |
| JPS554100B2 (en) | 1980-01-29 |
| FR2206951B1 (en) | 1976-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |