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GB1457245A - Cyclohexenyl compounds - Google Patents

Cyclohexenyl compounds

Info

Publication number
GB1457245A
GB1457245A GB1567075A GB1567075A GB1457245A GB 1457245 A GB1457245 A GB 1457245A GB 1567075 A GB1567075 A GB 1567075A GB 1567075 A GB1567075 A GB 1567075A GB 1457245 A GB1457245 A GB 1457245A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
oxocyclohex
formula
image
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1567075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/555,308 external-priority patent/US4002767A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of GB1457245A publication Critical patent/GB1457245A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Oxocyclohex-1-en-1-ylureas of the formula (I) <IMAGE> in which R1, R2 and R3 denote alkyl groups having 1 to 3 carbon atoms or alkenyl groups having 2 to 3 carbon atoms, where the total number of the carbon atoms of R1, R2 and R3 does not exceed five and two of the radicals R1, R2 and R3 can be bonded to one another to form a cycloalkyl or cycloalkenyl group, preferably 1-tert-butyl-3-(3-oxocyclohex-1-en-1-yl)urea, exhibit antihypertensive activity in mammals. The said compounds are obtained by reaction of a compound of the formula II <IMAGE> with 1,3-cyclohexanedione.
GB1567075A 1974-04-17 1975-04-16 Cyclohexenyl compounds Expired GB1457245A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46169774A 1974-04-17 1974-04-17
US52544574A 1974-11-20 1974-11-20
US05/555,308 US4002767A (en) 1974-11-20 1975-03-11 1-Tertiary-alkyl-3-(substituted cyclohexenyl)ureas as antihypertensive agents

Publications (1)

Publication Number Publication Date
GB1457245A true GB1457245A (en) 1976-12-01

Family

ID=27412847

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1567075A Expired GB1457245A (en) 1974-04-17 1975-04-16 Cyclohexenyl compounds

Country Status (18)

Country Link
JP (1) JPS50148337A (en)
AR (1) AR206020A1 (en)
CA (1) CA1051029A (en)
CH (1) CH611273A5 (en)
DD (1) DD119223A5 (en)
DE (1) DE2516556A1 (en)
DK (1) DK134318B (en)
ES (1) ES436647A1 (en)
FI (1) FI751127A7 (en)
FR (1) FR2267766B1 (en)
GB (1) GB1457245A (en)
IE (1) IE40999B1 (en)
IL (1) IL47097A (en)
LU (1) LU72305A1 (en)
NL (1) NL7504568A (en)
NO (1) NO751350L (en)
PH (1) PH11869A (en)
SE (1) SE398116B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424162A1 (en) * 1978-04-24 1979-11-23 British Hovercraft Corp Ltd Aircushon vehicle skirt rip stopper - has flexible core chemically bonded in fabric reinforced elastomer sheath with tensile load path discontinuities

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004959A1 (en) * 1978-04-24 1979-10-31 Ciba-Geigy Ag Process for preparing 3-oxo-cyclopentenyl ureas, compounds thus obtained, pharmaceutical compositions containing them and 3-oxo-cyclopentenylisothio ureas
DE3862944D1 (en) * 1987-02-09 1991-07-04 Ciba Geigy Ag NEW CYCLOHEXANDIONE.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424162A1 (en) * 1978-04-24 1979-11-23 British Hovercraft Corp Ltd Aircushon vehicle skirt rip stopper - has flexible core chemically bonded in fabric reinforced elastomer sheath with tensile load path discontinuities

Also Published As

Publication number Publication date
DK134318C (en) 1977-04-18
ES436647A1 (en) 1977-08-01
IE40999B1 (en) 1979-09-26
JPS50148337A (en) 1975-11-27
CH611273A5 (en) 1979-05-31
IL47097A (en) 1978-03-10
DE2516556A1 (en) 1975-10-30
DK163975A (en) 1975-10-18
FR2267766A1 (en) 1975-11-14
SE7503522L (en) 1975-10-20
SE398116B (en) 1977-12-05
IL47097A0 (en) 1975-06-25
FI751127A7 (en) 1975-10-18
AR206020A1 (en) 1976-06-23
IE40999L (en) 1975-10-17
LU72305A1 (en) 1976-03-17
CA1051029A (en) 1979-03-20
NO751350L (en) 1975-10-20
DK134318B (en) 1976-10-18
DD119223A5 (en) 1976-04-12
PH11869A (en) 1978-08-04
NL7504568A (en) 1975-10-21
FR2267766B1 (en) 1978-10-06
AU8013475A (en) 1976-10-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee