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GB1455884A - Production of capsules - Google Patents

Production of capsules

Info

Publication number
GB1455884A
GB1455884A GB714173A GB714173A GB1455884A GB 1455884 A GB1455884 A GB 1455884A GB 714173 A GB714173 A GB 714173A GB 714173 A GB714173 A GB 714173A GB 1455884 A GB1455884 A GB 1455884A
Authority
GB
United Kingdom
Prior art keywords
capsules
cap
cellulose
materials
portions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB714173A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Priority to GB714173A priority Critical patent/GB1455884A/en
Priority to CA190,680A priority patent/CA1028951A/en
Priority to IE143/74A priority patent/IE38792B1/en
Priority to ZA00740543A priority patent/ZA74543B/en
Priority to IL44109A priority patent/IL44109A/en
Priority to AU65064/74A priority patent/AU484816B2/en
Priority to HU74LI00000249A priority patent/HU172393B/en
Priority to FR7404059A priority patent/FR2216985B1/fr
Priority to DE19742406021 priority patent/DE2406021A1/en
Priority to SE7401793A priority patent/SE413836B/en
Priority to NL7401812A priority patent/NL7401812A/xx
Priority to DD176513A priority patent/DD109509A5/xx
Priority to YU00367/74A priority patent/YU36774A/en
Priority to JP49017489A priority patent/JPS5029734A/ja
Priority to BE6044458A priority patent/BE810991A/en
Priority to AT113274A priority patent/AT336794B/en
Priority to CS741086A priority patent/CS191908B2/en
Priority to ES423259A priority patent/ES423259A1/en
Priority to CH207474A priority patent/CH592447A5/xx
Priority to DK78174AA priority patent/DK137166B/en
Priority to ES1976219627U priority patent/ES219627Y/en
Publication of GB1455884A publication Critical patent/GB1455884A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/14—Dipping a core

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

1455884 Telescopic capsules LILLY INDUSTRIES Ltd 12 Feb 1974 [14 Feb 1973] 7141/73 Heading B8C Telescopic capsules, e.g. for pharmaceutical use are comprised of conventionally shaped body and cap portions, both of which are composed of two superposed layers of different materials which are soluble in aqueous media in different but overlapping pH ranges. Both portions are manufactured separately, e.g. by a conventional dipping progress wherein the body and cap pins are dipped successively in solutions of the two materials. Subsequent to manufacture of the separate body and cap portions, the capsules may be filled, closed and sealed by application of a circumferential band at the junction of cap and body e.g. of the same material as the outer layer of the capsule walls. Suitable materials for the first (inner) layer are; gelatin (preferred), calcium alynate, methyl cellulose and hydroxy cellulose-alkyl cellulose ethers. Suitable materials for the outer layer are; salol, benzoin, nbutyl stearate, carnuba wax, shellac, methacrylis acid polymers, carboxyvinyl polymers, maleic anhydride-vinyl alkyl ether or alkene copolymers and cellulose derrivates. For medicaments, these which are substantially insoluble below about pH 3À5 are preferred, these giving enteric capsules.
GB714173A 1973-02-14 1973-02-14 Production of capsules Expired GB1455884A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GB714173A GB1455884A (en) 1973-02-14 1973-02-14 Production of capsules
CA190,680A CA1028951A (en) 1973-02-14 1974-01-22 Production of capsules
IE143/74A IE38792B1 (en) 1973-02-14 1974-01-24 Improvements in the production of capsules
ZA00740543A ZA74543B (en) 1973-02-14 1974-01-25 Improvement in the production of capsules
IL44109A IL44109A (en) 1973-02-14 1974-01-29 Capsules and their manufacture
AU65064/74A AU484816B2 (en) 1973-02-14 1974-01-31 Improvements inthe production of capsules
HU74LI00000249A HU172393B (en) 1973-02-14 1974-02-04 Capsules and process for producing them
FR7404059A FR2216985B1 (en) 1973-02-14 1974-02-07
DE19742406021 DE2406021A1 (en) 1973-02-14 1974-02-08 CAPSULES, METHOD FOR MANUFACTURING AND USING them
SE7401793A SE413836B (en) 1973-02-14 1974-02-11 PROCEDURE FOR MANUFACTURING CAPSULES
NL7401812A NL7401812A (en) 1973-02-14 1974-02-11
DD176513A DD109509A5 (en) 1973-02-14 1974-02-12
YU00367/74A YU36774A (en) 1973-02-14 1974-02-13 Hard-gelatine-type capsule
JP49017489A JPS5029734A (en) 1973-02-14 1974-02-13
BE6044458A BE810991A (en) 1973-02-14 1974-02-13 IMPROVED CAPSULES AND THEIR MANUFACTURING PROCESS
AT113274A AT336794B (en) 1973-02-14 1974-02-13 CAPSULES FOR ENCLOSING PHARMACEUTICAL PREPARATIONS AND METHOD FOR THEIR MANUFACTURING
CS741086A CS191908B2 (en) 1973-02-14 1974-02-14 Pill and method of making the same
ES423259A ES423259A1 (en) 1973-02-14 1974-02-14 Production of capsules
CH207474A CH592447A5 (en) 1973-02-14 1974-02-14
DK78174AA DK137166B (en) 1973-02-14 1974-02-14 Capsule shell and process for its manufacture.
ES1976219627U ES219627Y (en) 1973-02-14 1976-03-16 A PERFECTED CAPSULE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB714173A GB1455884A (en) 1973-02-14 1973-02-14 Production of capsules

Publications (1)

Publication Number Publication Date
GB1455884A true GB1455884A (en) 1976-11-17

Family

ID=9827403

Family Applications (1)

Application Number Title Priority Date Filing Date
GB714173A Expired GB1455884A (en) 1973-02-14 1973-02-14 Production of capsules

Country Status (19)

Country Link
JP (1) JPS5029734A (en)
AT (1) AT336794B (en)
BE (1) BE810991A (en)
CA (1) CA1028951A (en)
CH (1) CH592447A5 (en)
CS (1) CS191908B2 (en)
DD (1) DD109509A5 (en)
DE (1) DE2406021A1 (en)
DK (1) DK137166B (en)
ES (2) ES423259A1 (en)
FR (1) FR2216985B1 (en)
GB (1) GB1455884A (en)
HU (1) HU172393B (en)
IE (1) IE38792B1 (en)
IL (1) IL44109A (en)
NL (1) NL7401812A (en)
SE (1) SE413836B (en)
YU (1) YU36774A (en)
ZA (1) ZA74543B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129445A1 (en) * 1983-06-20 1984-12-27 Cosden Technology Inc. Process for forming tamper-resistant tamper-indicative capsules
GB2361643A (en) * 2000-02-16 2001-10-31 Bioprogress Tech Int Inc Two-layer capsules
GB2398499A (en) * 2000-02-16 2004-08-25 Bioprogress Technology Ltd Two layer capsules
CN104905967A (en) * 2015-05-23 2015-09-16 浙江益立胶囊股份有限公司 Production mold for double-layer enteric hollow capsule
WO2022112422A1 (en) 2020-11-25 2022-06-02 Capsugel France SAS Double layered delayed-release hard capsules
EP4559458A1 (en) 2022-07-22 2025-05-28 Qualicaps Co., Ltd. Multilayered enteric rigid capsule

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01232963A (en) * 1988-03-14 1989-09-18 Arimento Kogyo Kk Double-layer soft capsule and preparation thereof
AT397764B (en) * 1992-07-23 1994-06-27 Schlegel Christoph Device for automatic opening and emptying of capsules
TW245641B (en) * 1993-04-26 1995-04-21 Takeda Pharm Industry Co
FR2771660B1 (en) * 1997-11-28 2000-01-14 Industrialisation Concept Et M PROCESS FOR FORMING AND DEPOSITING A DETERMINED DOSE OF A LIQUID OR PASTY PRODUCT AND INSTALLATION FOR IMPLEMENTING THE PROCESS
DE102009010091A1 (en) * 2009-02-24 2010-08-26 Beiersdorf Ag Stabilized peeling capsule
WO2013050973A1 (en) 2011-10-06 2013-04-11 Market Demand Trading 767 Proprietary Limited A method and apparatus for manufacturing a capsule

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB493934A (en) * 1936-01-17 1938-10-17 Hugo Remmler Ag Dr Improvements in and relating to methods of treating medicaments
GB638284A (en) * 1946-03-25 1950-06-07 Parke Davis & Co Improvements in or relating to enteric capsules

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129445A1 (en) * 1983-06-20 1984-12-27 Cosden Technology Inc. Process for forming tamper-resistant tamper-indicative capsules
GB2361643A (en) * 2000-02-16 2001-10-31 Bioprogress Tech Int Inc Two-layer capsules
GB2398499A (en) * 2000-02-16 2004-08-25 Bioprogress Technology Ltd Two layer capsules
GB2361643B (en) * 2000-02-16 2004-11-24 Bioprogress Tech Int Inc Delivery capsules
GB2398499B (en) * 2000-02-16 2004-11-24 Bioprogress Technology Ltd Two layer capsules
CN104905967A (en) * 2015-05-23 2015-09-16 浙江益立胶囊股份有限公司 Production mold for double-layer enteric hollow capsule
CN104905967B (en) * 2015-05-23 2019-04-16 浙江益立胶囊股份有限公司 Production mould for the double-deck enteric hollow capsule
WO2022112422A1 (en) 2020-11-25 2022-06-02 Capsugel France SAS Double layered delayed-release hard capsules
EP4464313A2 (en) 2020-11-25 2024-11-20 Capsugel Belgium NV Double layered delayed-release hard capsules
EP4467132A2 (en) 2020-11-25 2024-11-27 Capsugel Belgium NV Double layered delayed-release hard capsules
EP4674411A2 (en) 2020-11-25 2026-01-07 Capsugel Belgium NV Double layered delayed-release hard capsules
EP4559458A1 (en) 2022-07-22 2025-05-28 Qualicaps Co., Ltd. Multilayered enteric rigid capsule

Also Published As

Publication number Publication date
FR2216985A1 (en) 1974-09-06
FR2216985B1 (en) 1977-06-10
AU6506474A (en) 1975-07-31
AT336794B (en) 1977-05-25
DK137166B (en) 1978-01-30
DK137166C (en) 1978-07-03
ES423259A1 (en) 1976-11-16
IE38792B1 (en) 1978-06-07
HU172393B (en) 1978-08-28
IL44109A (en) 1976-10-31
IE38792L (en) 1974-08-14
ES219627U (en) 1976-11-01
SE413836B (en) 1980-06-30
YU36774A (en) 1983-02-28
NL7401812A (en) 1974-08-16
CH592447A5 (en) 1977-10-31
JPS5029734A (en) 1975-03-25
BE810991A (en) 1974-08-13
IL44109A0 (en) 1974-05-16
DE2406021A1 (en) 1974-08-29
ATA113274A (en) 1976-09-15
ZA74543B (en) 1975-09-24
DD109509A5 (en) 1974-11-12
ES219627Y (en) 1977-03-01
CS191908B2 (en) 1979-07-31
CA1028951A (en) 1978-04-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19940211