GB1453034A - Pharmaceutical composition for treating spasticity - Google Patents
Pharmaceutical composition for treating spasticityInfo
- Publication number
- GB1453034A GB1453034A GB5808872A GB5808872A GB1453034A GB 1453034 A GB1453034 A GB 1453034A GB 5808872 A GB5808872 A GB 5808872A GB 5808872 A GB5808872 A GB 5808872A GB 1453034 A GB1453034 A GB 1453034A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- dihydroxyphenyl
- butylaminoethane
- tert
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000008238 Muscle Spasticity Diseases 0.000 title 1
- 208000018198 spasticity Diseases 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 abstract 1
- OXBBIHZWNDPBMQ-UHFFFAOYSA-N 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 OXBBIHZWNDPBMQ-UHFFFAOYSA-N 0.000 abstract 1
- QPYZEEKXUYXZBK-UHFFFAOYSA-N 4-[hydroxy(piperidin-2-yl)methyl]benzene-1,2-diol;hydrobromide Chemical compound Br.C=1C=C(O)C(O)=CC=1C(O)C1CCCCN1 QPYZEEKXUYXZBK-UHFFFAOYSA-N 0.000 abstract 1
- QYDZOQAGVTYFSI-UHFFFAOYSA-N 5-[1-amino-1-hydroxy-4-(4-hydroxyphenyl)-3-methylbutyl]benzene-1,3-diol Chemical compound OC=1C=C(C=C(C1)O)C(CC(C)CC1=CC=C(C=C1)O)(O)N QYDZOQAGVTYFSI-UHFFFAOYSA-N 0.000 abstract 1
- RSDQHEMTUCMUPQ-UHFFFAOYSA-N 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]quinolin-8-ol Chemical compound C1=CC=C2C(C(O)CNC(C)C)=CC=C(O)C2=N1 RSDQHEMTUCMUPQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- QSRHLIUOSXVKTG-UHFFFAOYSA-N eprozinol Chemical compound C=1C=CC=CC=1C(OC)CN(CC1)CCN1CCC(O)C1=CC=CC=C1 QSRHLIUOSXVKTG-UHFFFAOYSA-N 0.000 abstract 1
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexamethylene diamine Natural products NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 abstract 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000001975 sympathomimetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1453034 Skeletal muscle relaxing preparations BOEHRINGER INGELHEIM GmbH 14 Dec 1973 [15 Dec 1972] 58088/72 Heading A5B . A pharmaceutical composition for use in the treatment of spastically disabled human being comprises a sympathomimetic amine or a physiologically acceptable salt thereof together with an effective amount of sustained or delayed release agent, said amine being: 1-(3, 5-dihydroxyphenyl)-1 -hydroxy-2-isopropylaminoethane; 1-(4-amino-3, 5-dichlorophenyl) - 1 -hydroxy-2-tert-butylaminoethane; 1-(3-hydroxymethyl -4- hydroxyphenyl) -1- hydroxy -2- tert butylaminoethane; 1-(3, 5 - dihydroxyphenyl) -1- hydroxy -2- (1-(4-hydroxybenzyl) ethyl)-aminoethane; 1-(3, 5-dihydroxyphenyl)- 1 -hydroxy-2-tert butylaminoethane; N, N'-bis- [1-(3, 4-dihydroxyphenyl)-1-hydroxyethyl (2)]- hexamethylenediamine; 1-(3, 4-dihydroxyphenyl)-1 -hydroxy-2-isopropylaminoethane; 2-[(3, 4-dihydroxyphenyl) hydroxymethyl] piperidinium hydrobromide; 8-hydroxy-5-( 1 -hydroxy-2- isopropylaminoethyl) quinoline; 1-diphenylmethyl-4-hydroxyethoxyethyl-piperazine; 1 -phenethylpiperidine-4-spiro-5'-[1', 3']-oxazolidin-2'- one; and 1-(2-phenyl-2-methoxyethyl)-4-(3-hydroxy-3-phenylpropyl) piperazine. The composition may be in a form suitable for oral or parenteral administration.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5808872A GB1453034A (en) | 1972-12-15 | 1972-12-15 | Pharmaceutical composition for treating spasticity |
| IE2267/73A IE38655B1 (en) | 1972-12-15 | 1973-12-14 | Pharmaceutical compositions for treating spasticity |
| IL43820A IL43820A (en) | 1972-12-15 | 1973-12-14 | Pharmaceutical compositions for treatment of spastically disabled human beings containing bronchodilating sympathomimetic amines |
| AU63647/73A AU491048B2 (en) | 1972-12-15 | 1973-12-14 | Chemical compositions |
| DE2362123A DE2362123A1 (en) | 1972-12-15 | 1973-12-14 | PHARMACEUTICAL PREPARATIONS |
| BE138890A BE808662A (en) | 1972-12-15 | 1973-12-14 | SYMPATHOMIMETIC AMINE COMPOSITIONS |
| ZA00739480*DA ZA739480B (en) | 1972-12-15 | 1973-12-14 | Improvements relating to compositions for treating spastic disablement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5808872A GB1453034A (en) | 1972-12-15 | 1972-12-15 | Pharmaceutical composition for treating spasticity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1453034A true GB1453034A (en) | 1976-10-20 |
Family
ID=10480743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5808872A Expired GB1453034A (en) | 1972-12-15 | 1972-12-15 | Pharmaceutical composition for treating spasticity |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE808662A (en) |
| DE (1) | DE2362123A1 (en) |
| GB (1) | GB1453034A (en) |
| IE (1) | IE38655B1 (en) |
| IL (1) | IL43820A (en) |
| ZA (1) | ZA739480B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0120165A3 (en) * | 1982-12-10 | 1985-06-19 | Frank L. Greenway Iii | A preparation and a process for achieving regional weight control |
| US4751071A (en) * | 1983-12-01 | 1988-06-14 | Alza Corporation | Composition comprising salbutamol |
| US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
| US4851229A (en) * | 1983-12-01 | 1989-07-25 | Alza Corporation | Composition comprising a therapeutic agent and a modulating agent |
| AT390191B (en) * | 1982-05-27 | 1990-03-26 | Glaxo Group Ltd | METHOD FOR PRODUCING LIQUID PHARMACEUTICAL COMPOSITIONS WITH A CONTENT OF 2-TERT.BUTYLAMINO-1- (4'-HYDROXY-3'HYDROXYMETHYLPHENYL) -ETHANOL (1) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1574894A (en) * | 1977-06-02 | 1980-09-10 | Nippon Kayaku Kk | Derivative of a-methyl-aminopropiophenone and use thereof |
| DE2929456A1 (en) * | 1979-07-20 | 1981-02-05 | Lentia Gmbh | COMPOSITION WITH EXTENDED BRONCHOLYTIC AND TOCOLYTIC EFFECTIVENESS, A METHOD FOR THE PRODUCTION THEREOF AND BRONCHOLYTIC AND TOKOLYTICALLY ACTIVE AGENT |
| US5468501A (en) * | 1982-09-01 | 1995-11-21 | Hercon Laboratories Corporation | Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant |
| US5310559A (en) * | 1982-09-01 | 1994-05-10 | Hercon Laboratories Corporation | Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer |
| JPS6061523A (en) * | 1983-09-16 | 1985-04-09 | Shionogi & Co Ltd | Oral dobutamine pharmaceutical |
| EP0251425B1 (en) * | 1986-04-03 | 1993-06-16 | Hercon Laboratories Corporation | Article for administration of pharmacologically-active substances |
-
1972
- 1972-12-15 GB GB5808872A patent/GB1453034A/en not_active Expired
-
1973
- 1973-12-14 ZA ZA00739480*DA patent/ZA739480B/en unknown
- 1973-12-14 IE IE2267/73A patent/IE38655B1/en unknown
- 1973-12-14 BE BE138890A patent/BE808662A/en unknown
- 1973-12-14 DE DE2362123A patent/DE2362123A1/en active Pending
- 1973-12-14 IL IL43820A patent/IL43820A/en unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT390191B (en) * | 1982-05-27 | 1990-03-26 | Glaxo Group Ltd | METHOD FOR PRODUCING LIQUID PHARMACEUTICAL COMPOSITIONS WITH A CONTENT OF 2-TERT.BUTYLAMINO-1- (4'-HYDROXY-3'HYDROXYMETHYLPHENYL) -ETHANOL (1) |
| EP0120165A3 (en) * | 1982-12-10 | 1985-06-19 | Frank L. Greenway Iii | A preparation and a process for achieving regional weight control |
| US4751071A (en) * | 1983-12-01 | 1988-06-14 | Alza Corporation | Composition comprising salbutamol |
| US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
| US4851229A (en) * | 1983-12-01 | 1989-07-25 | Alza Corporation | Composition comprising a therapeutic agent and a modulating agent |
Also Published As
| Publication number | Publication date |
|---|---|
| IE38655B1 (en) | 1978-05-10 |
| AU6364773A (en) | 1975-06-19 |
| ZA739480B (en) | 1975-08-27 |
| BE808662A (en) | 1974-06-14 |
| IE38655L (en) | 1974-06-15 |
| IL43820A (en) | 1977-08-31 |
| IL43820A0 (en) | 1974-03-14 |
| DE2362123A1 (en) | 1974-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |