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GB1453049A - Cephalosporing antibiotics - Google Patents

Cephalosporing antibiotics

Info

Publication number
GB1453049A
GB1453049A GB3964573A GB3964573A GB1453049A GB 1453049 A GB1453049 A GB 1453049A GB 3964573 A GB3964573 A GB 3964573A GB 3964573 A GB3964573 A GB 3964573A GB 1453049 A GB1453049 A GB 1453049A
Authority
GB
United Kingdom
Prior art keywords
compound
syn isomer
ceph
phenyl
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3964573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10410683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1453049(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB3964573A priority Critical patent/GB1453049A/en
Priority to US05/413,970 priority patent/US3966717A/en
Priority to CY945A priority patent/CY945A/en
Priority to US05/497,113 priority patent/US3974153A/en
Priority to RO7479828A priority patent/RO64129A/en
Priority to RO7486148A priority patent/RO69607A/en
Priority to DE2439880A priority patent/DE2439880C3/en
Priority to AU72531/74A priority patent/AU473550B2/en
Priority to BE147745A priority patent/BE819004R/en
Priority to JP9545674A priority patent/JPS562077B2/ja
Priority to DD180622A priority patent/DD114417A5/xx
Priority to BG027524A priority patent/BG25801A3/en
Priority to YU2283/74A priority patent/YU36737B/en
Priority to PL1974173581A priority patent/PL98962B1/en
Priority to IE1735/74A priority patent/IE39764B1/en
Priority to ZA00745331A priority patent/ZA745331B/en
Priority to NO742986A priority patent/NO152751C/en
Priority to DK443274A priority patent/DK147683C/en
Priority to FI2456/74A priority patent/FI65623C/en
Priority to CA207,441A priority patent/CA1057283A/en
Priority to BG031288A priority patent/BG23903A3/en
Priority to DE19742462376 priority patent/DE2462376A1/en
Priority to CS745783A priority patent/CS204989B2/en
Priority to AT676374A priority patent/AT340042B/en
Priority to NL747411095A priority patent/NL154741B/en
Priority to CS745783A priority patent/CS204988B2/en
Priority to LU70765A priority patent/LU70765A1/xx
Priority to CH1135374A priority patent/CH613975A5/en
Priority to PL1974196434A priority patent/PL115805B1/en
Priority to LU88269C priority patent/LU88269I2/xx
Priority to AR255247A priority patent/AR212076A1/en
Priority to IL45505A priority patent/IL45505A/en
Priority to ES429388A priority patent/ES429388A1/en
Priority to HUGA1166A priority patent/HU170000B/hu
Priority to FR7428750A priority patent/FR2241318B2/fr
Priority to ES437269A priority patent/ES437269A1/en
Priority to AR258764A priority patent/AR212156A1/en
Priority to SU762343055A priority patent/SU633483A3/en
Priority to AT609976A priority patent/AT340597B/en
Publication of GB1453049A publication Critical patent/GB1453049A/en
Priority to US05/852,808 priority patent/US4138555A/en
Priority to CA293,802A priority patent/CA1048016A/en
Priority to KE2816A priority patent/KE2816A/en
Priority to HK173/78A priority patent/HK17378A/en
Priority to CH1013378A priority patent/CH615931A5/en
Priority to MY1978188A priority patent/MY7800188A/en
Priority to JP7210780A priority patent/JPS5649388A/en
Priority to YU307/81A priority patent/YU41231B/en
Priority to FI831279A priority patent/FI831279L/en
Priority to GT198302370A priority patent/GT198302370A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I <IMAGE> in which B is > S or > S->O; R<1> is furyl, thienyl or phenyl; and R<2> is C1-C4-alkyl, C3-C7-cycloalkyl or phenyl, and of their non-toxic salts, including their solvates, and esters by acylation of the corresponding 7-amino compound, where appropriate with intermediate protection of the 4-carboxyl group and/or of the 3-carbamoyloxymethyl group, and subsequent isomerisation of a ceph-2-em compound which is obtained where appropriate to the ceph-3-em compound. The compounds are distinguished by a broad spectrum of action on pathogenic microorganisms, the ability to resist beta -lactamases and good stability in vivo.
GB3964573A 1971-05-14 1973-08-21 Cephalosporing antibiotics Expired GB1453049A (en)

Priority Applications (49)

Application Number Priority Date Filing Date Title
GB3964573A GB1453049A (en) 1973-08-21 1973-08-21 Cephalosporing antibiotics
US05/413,970 US3966717A (en) 1971-05-14 1973-11-08 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
CY945A CY945A (en) 1973-08-21 1974-08-13 Cephalosporin antibiotics
US05/497,113 US3974153A (en) 1971-05-14 1974-08-13 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
RO7479828A RO64129A (en) 1973-08-21 1974-08-19 PROCESS FOR THE PREPARATION OF CEPHALOSPORI DERIVATIVES
RO7486148A RO69607A (en) 1973-08-21 1974-08-19 PROCESS FOR PREPARATION OF 3-CARBAMOYLOXYETHYLPHALOSPORINE
DE2439880A DE2439880C3 (en) 1973-08-21 1974-08-20 (6R, 7R) -3-Carbamoyloxymethyl-7- [2- (fur-2-yl) -2methoxyiminoacetamido] -ceph-S-em ^ carboxylic acid and process for its preparation
AU72531/74A AU473550B2 (en) 1973-08-21 1974-08-20 Improvements in or relating to antibiotics
BE147745A BE819004R (en) 1973-08-21 1974-08-20 IMPROVEMENTS RELATED TO ANTIBIOTICS
JP9545674A JPS562077B2 (en) 1973-08-21 1974-08-20
DD180622A DD114417A5 (en) 1973-08-21 1974-08-20
BG027524A BG25801A3 (en) 1973-08-21 1974-08-20 METHOD FOR THE PREPARATION OF 7-BETA-(2-ARYL-2)(ESTERIFIED OXIMINO)ACETAMIDO)-3-CARBAMOYLOXIMETHYL-CEF-3-EM-4-CARBONIC ACID
YU2283/74A YU36737B (en) 1973-08-21 1974-08-20 Process for obtaining an antibiotic compound
PL1974173581A PL98962B1 (en) 1973-08-21 1974-08-20 METHOD OF PRODUCTION OF NEW DERIVATIVES OF CEPHALOSPORIN
IE1735/74A IE39764B1 (en) 1973-08-21 1974-08-20 Cephalosporin antibiotics
ZA00745331A ZA745331B (en) 1973-08-21 1974-08-20 Improvements in or relating to antibiotics
NO742986A NO152751C (en) 1973-08-21 1974-08-20 ANALOGY PROCEDURE FOR THE PREPARATION OF A THERAPEUTIC EFFECTIVE CEPHALOSPORIN DERIVATIVE.
DK443274A DK147683C (en) 1973-08-21 1974-08-20 METHOD OF ANALOGY FOR THE PREPARATION OF CEPHALOSPORINE COMPOUNDS OR TOXIC SALTS, BIOLOGICAL ACCEPTABLE ESTERS, 1-OXYDS OR SOLVATES THEREOF
FI2456/74A FI65623C (en) 1973-08-21 1974-08-20 EXAMINATION OF ANTIBIOTICS ACTIVE (6R 7R) -3-CARBAMOYLOXIMETHYL-7- (2- (FUR-2-YL) -2-METHOXIMINOACETAMIDO) -CEF-3-EM-4-CARBOXYL SYRICATE
CA207,441A CA1057283A (en) 1973-08-21 1974-08-20 3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido) ceph-3-em-4-carboxylic acid
BG031288A BG23903A3 (en) 1973-08-21 1974-08-20 METHOD FOR THE PREPARATION OF 7-B/2-ARYL-2(ETERIFIED OXIMINO)ACETAMIDO/ -3-CARBAMIOLOXYMETHYLCEPH-3-EM-4-CARBONILIC ACID
DE19742462376 DE2462376A1 (en) 1973-08-21 1974-08-20 ANTIBIOTICS AND THE METHOD OF MANUFACTURING THEREOF
CS745783A CS204989B2 (en) 1973-08-21 1974-08-20 Method of producing cephalosporin antibiotics
AT676374A AT340042B (en) 1973-08-21 1974-08-20 PROCESS FOR PRODUCING NEW ANTIBIOTIC COMPOUNDS
NL747411095A NL154741B (en) 1973-08-21 1974-08-20 PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTIBIOTIC ACTION, AS WELL AS THE OBTAINED PREPARED MEDICINAL PRODUCT AND PROCEDURE FOR THE PREPARATION OF AN ETHER DERIVED FROM AN (6R, 7R) -3-ACYLOXYL-IN-2-ARYL-2-YL-YL-IN-YL-IN-2-YL CEF-3-EM-4-CARBONIC ACID COMPOUND.
CS745783A CS204988B2 (en) 1973-08-21 1974-08-20 Process for preparing cephalosporine antibiotics
LU70765A LU70765A1 (en) 1973-08-21 1974-08-20
CH1135374A CH613975A5 (en) 1973-08-21 1974-08-20 Process for the preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity
PL1974196434A PL115805B1 (en) 1973-08-21 1974-08-20 Process for preparing novel derivatives of cephalosporin
LU88269C LU88269I2 (en) 1973-08-21 1974-08-20
AR255247A AR212076A1 (en) 1973-08-21 1974-08-20 PROCEDURE FOR THE PREPARATION OF ANTIBIOTICS OF 7B- / 2-ARIL-2- (ETERIFIED OXIMINE) ACETAMIDE / -3-CARBAMOYLOXIMETHYL ETH-3-EM-4-CARBOXYL ACID
IL45505A IL45505A (en) 1973-08-21 1974-08-20 7-(2-aryl-2-(etherified oximino)acetamido)-3-(carbamoyloxyymethyl)-ceph-3-em-4-carboxylic acids and their derivatives,their preparation and pharmaceutical compositions comprising them
ES429388A ES429388A1 (en) 1973-08-21 1974-08-20 Cephalosporing antibiotics
HUGA1166A HU170000B (en) 1973-08-21 1974-08-21
FR7428750A FR2241318B2 (en) 1973-08-21 1974-08-21
ES437269A ES437269A1 (en) 1973-08-21 1975-04-30 A PROCEDURE FOR THE PREPARATION OF A 7BETA- (2-ARYL-2- (ETERIFIED OXIMINE) ACETAMIDE) -3- CARBAMOYLOXIMETHYLCH-3-EM-4-CARBOXYL ANTIBIOTIC.
AR258764A AR212156A1 (en) 1973-08-21 1975-05-13 PROCEDURE FOR THE PREPARATION OF AN ANTIBIOTIC OF ACID 7B- (2-ARYL-2- (STERIFIED OXIMINE) ACETAMIDE) -3-CARBAMOYLOXIMETHYLCEF-3-EM-4-CARBOXYL
SU762343055A SU633483A3 (en) 1973-08-21 1976-04-08 Method of obtaining cephalosporin derivatives as syn-isomer or mixture of syn- and anti-isomers or their salts
AT609976A AT340597B (en) 1973-08-21 1976-08-17 PROCESS FOR PRODUCING NEW ANTIBIOTIC COMPOUNDS
US05/852,808 US4138555A (en) 1971-05-14 1977-11-18 (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
CA293,802A CA1048016A (en) 1973-08-21 1977-12-23 Antibiotics
KE2816A KE2816A (en) 1973-08-21 1978-02-06 Cephalosporin antibiotics
HK173/78A HK17378A (en) 1973-08-21 1978-03-30 Cephalosporin antibiotics
CH1013378A CH615931A5 (en) 1973-08-21 1978-09-28 Process for the preparation of the syn isomer or of a mixture of syn and anti isomers, the content of the syn isomer being at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids
MY1978188A MY7800188A (en) 1973-08-21 1978-12-31 Cephalosporin antibiotics
JP7210780A JPS5649388A (en) 1973-08-21 1980-05-28 Manufacture of antibiotic compound
YU307/81A YU41231B (en) 1973-08-21 1981-02-05 Process for obtaining new antibiotic compounds
FI831279A FI831279L (en) 1973-08-21 1983-04-15 PROFESSIONAL PROTECTION OF ANTIBIOTICS ACTIVE (6R, 7R) -3-CARBAMOYLOXIMETHYL-7- (2-FUR-2-YL) -2-METHOXIMINOACETAMIDE / -CEF-3-EM-4-CARBOXYL SYRASE
GT198302370A GT198302370A (en) 1973-08-21 1983-05-30 IMPROVEMENTS IN OR RELATED TO ANTIBIOTICS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3964573A GB1453049A (en) 1973-08-21 1973-08-21 Cephalosporing antibiotics

Publications (1)

Publication Number Publication Date
GB1453049A true GB1453049A (en) 1976-10-20

Family

ID=10410683

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3964573A Expired GB1453049A (en) 1971-05-14 1973-08-21 Cephalosporing antibiotics

Country Status (32)

Country Link
JP (2) JPS562077B2 (en)
AR (2) AR212076A1 (en)
AT (1) AT340042B (en)
AU (1) AU473550B2 (en)
BE (1) BE819004R (en)
BG (2) BG25801A3 (en)
CA (1) CA1057283A (en)
CH (2) CH613975A5 (en)
CS (2) CS204989B2 (en)
CY (1) CY945A (en)
DD (1) DD114417A5 (en)
DE (2) DE2439880C3 (en)
DK (1) DK147683C (en)
ES (2) ES429388A1 (en)
FI (1) FI65623C (en)
FR (1) FR2241318B2 (en)
GB (1) GB1453049A (en)
GT (1) GT198302370A (en)
HK (1) HK17378A (en)
HU (1) HU170000B (en)
IE (1) IE39764B1 (en)
IL (1) IL45505A (en)
KE (1) KE2816A (en)
LU (2) LU88269I2 (en)
MY (1) MY7800188A (en)
NL (1) NL154741B (en)
NO (1) NO152751C (en)
PL (2) PL98962B1 (en)
RO (2) RO64129A (en)
SU (1) SU633483A3 (en)
YU (2) YU36737B (en)
ZA (1) ZA745331B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (en) * 1977-04-19 1978-11-17 Glaxo Lab Ltd CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
GB2145408A (en) * 1983-07-29 1985-03-27 Glaxo Group Ltd Improvements in or relating to preparing sodium cefuroxime
GB2218093A (en) * 1988-05-03 1989-11-08 Glaxo Group Ltd Cephalosporin carbamoylation
WO2004050663A3 (en) * 2002-12-05 2004-10-28 Orchid Chemicals & Pharm Ltd An improved process for the preparation of cefuroxime sodium
WO2013024373A1 (en) 2011-08-12 2013-02-21 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
WO2013038323A1 (en) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Taste masked pharmaceutical compositions of cefuroxime axetil
CN105884799A (en) * 2015-09-23 2016-08-24 石药集团中诺药业（石家庄）有限公司 Novel cefuroxime sodium compound

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
FI771866A7 (en) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
IT1162442B (en) * 1978-01-17 1987-04-01 Glaxo Group Ltd PROCEDURE FOR PREPARING THE CRYSTALLINE SHAPED SODIUM SALT OF CEFUROSSIMA
DE2804040C3 (en) * 1978-01-31 1981-03-19 Hoechst Ag, 6000 Frankfurt Process for the preparation of cephem compounds
US4341777A (en) * 1979-09-10 1982-07-27 Glaxo Group Limited Cephalosporin antibiotic
IT1190734B (en) * 1982-03-11 1988-02-24 Opos Biochimica Srl PROCEDURE FOR THE PREPARATION OF CEFUROXIMA AND INTERMEDIATES USED IN SUCH PROCEDURE
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
WO2000053609A1 (en) * 1999-03-09 2000-09-14 Ranbaxy Laboratories Limited Process for the preparation of cefuroxime
US20040191803A1 (en) * 2002-11-22 2004-09-30 Michela Gallagher Target for therapy of cognitive impairment
JP2008275173A (en) * 2008-08-04 2008-11-13 Toshiba Corp Branch piping
KR101497420B1 (en) 2013-07-05 2015-03-03 삼성중공업 주식회사 LNG transportation Apparatus for reducing Boil-Off Gas

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (en) * 1977-04-19 1978-11-17 Glaxo Lab Ltd CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
GB2145408A (en) * 1983-07-29 1985-03-27 Glaxo Group Ltd Improvements in or relating to preparing sodium cefuroxime
AU567359B2 (en) * 1983-07-29 1987-11-19 Glaxo Group Limited Preparation of sodium cefuroxime
GB2218093A (en) * 1988-05-03 1989-11-08 Glaxo Group Ltd Cephalosporin carbamoylation
WO2004050663A3 (en) * 2002-12-05 2004-10-28 Orchid Chemicals & Pharm Ltd An improved process for the preparation of cefuroxime sodium
WO2013024373A1 (en) 2011-08-12 2013-02-21 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
WO2013038323A1 (en) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Taste masked pharmaceutical compositions of cefuroxime axetil
CN105884799A (en) * 2015-09-23 2016-08-24 石药集团中诺药业（石家庄）有限公司 Novel cefuroxime sodium compound

Also Published As

Publication number Publication date
HK17378A (en) 1978-04-07
JPS5649388A (en) 1981-05-02
AU473550B2 (en) 1976-06-24
MY7800188A (en) 1978-12-31
PL98962B1 (en) 1978-06-30
BG25801A3 (en) 1978-12-12
CA1057283A (en) 1979-06-26
DE2462376A1 (en) 1976-11-25
NO152751B (en) 1985-08-05
FI245674A7 (en) 1975-02-22
DK147683C (en) 1985-05-13
CH615931A5 (en) 1980-02-29
FI65623C (en) 1984-06-11
RO64129A (en) 1979-03-15
IE39764L (en) 1975-02-21
CS204989B2 (en) 1981-04-30
AT340042B (en) 1977-11-25
FR2241318A2 (en) 1975-03-21
AU7253174A (en) 1976-02-26
BG23903A3 (en) 1977-11-10
DK147683B (en) 1984-11-12
PL115805B1 (en) 1981-05-30
LU70765A1 (en) 1975-12-09
ES429388A1 (en) 1976-08-16
YU228374A (en) 1982-06-18
YU41231B (en) 1986-12-31
YU30781A (en) 1983-02-28
FI65623B (en) 1984-02-29
DD114417A5 (en) 1975-08-05
NO742986L (en) 1975-03-17
KE2816A (en) 1978-02-24
IE39764B1 (en) 1978-12-20
NO152751C (en) 1985-11-13
ATA676374A (en) 1977-03-15
DE2439880C3 (en) 1979-10-18
ES437269A1 (en) 1977-01-01
SU633483A3 (en) 1978-11-15
AR212156A1 (en) 1978-05-31
DE2439880A1 (en) 1975-04-03
FR2241318B2 (en) 1979-08-10
LU88269I2 (en) 1994-02-03
NL7411095A (en) 1975-02-25
BE819004R (en) 1975-02-20
NL154741B (en) 1977-10-17
DK443274A (en) 1975-04-28
JPS5052083A (en) 1975-05-09
CH613975A5 (en) 1979-10-31
AR212076A1 (en) 1978-05-15
HU170000B (en) 1977-03-28
DE2439880B2 (en) 1979-02-22
IL45505A0 (en) 1974-11-29
YU36737B (en) 1984-08-31
JPS562077B2 (en) 1981-01-17
RO69607A (en) 1980-08-15
CY945A (en) 1978-06-23
CS204988B2 (en) 1981-04-30
IL45505A (en) 1979-01-31
GT198302370A (en) 1984-11-20
ZA745331B (en) 1975-10-29

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PS Patent sealed [section 19, patents act 1949]
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Effective date: 19940812