GB1451724A - D-2-substituted-6-alkyl-8-substituted ergolines and process for preparing same - Google Patents
D-2-substituted-6-alkyl-8-substituted ergolines and process for preparing sameInfo
- Publication number
- GB1451724A GB1451724A GB534674A GB534674A GB1451724A GB 1451724 A GB1451724 A GB 1451724A GB 534674 A GB534674 A GB 534674A GB 534674 A GB534674 A GB 534674A GB 1451724 A GB1451724 A GB 1451724A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- ergoline
- alkyl
- ergolines
- preparing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1451724 D - 2 - substituted - 8 - substituted ergoline derivatives ELI LILLY CO 5 Feb 1974 [28 Nov 1973] 05346/74 Addition to 1423065 Heading C2C Novel ergoline derivatives of the Formula II wherein X is Cl, Br, I, CH 3 or CN, R is CH 2 CN or CH 2 CONH 2 , and R<SP>1</SP> is C 2-4 primary alkyl, or a radioactive C 14 methyl group and pharmaceutically acceptable acid-addition salts thereof may be prepared by demethylation of the corresponding 6-methyl ergoline to give the 6-unsubstituted ergoline II and then alkylation at the 6-position. Pharmaceutical compositions of the compounds II are prolactin inhibitors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US419566A US3920664A (en) | 1972-07-21 | 1973-11-28 | D-2-halo-6-alkyl-8-substituted ergolines and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1451724A true GB1451724A (en) | 1976-10-06 |
Family
ID=23662805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB534674A Expired GB1451724A (en) | 1973-11-28 | 1974-02-05 | D-2-substituted-6-alkyl-8-substituted ergolines and process for preparing same |
Country Status (25)
| Country | Link |
|---|---|
| JP (2) | JPS5084598A (en) |
| AR (1) | AR212072A1 (en) |
| AT (1) | AT333982B (en) |
| BE (1) | BE811610R (en) |
| BG (1) | BG22399A3 (en) |
| CA (1) | CA1011334A (en) |
| CH (1) | CH592088A5 (en) |
| CS (1) | CS175474B2 (en) |
| DD (1) | DD116828A6 (en) |
| DE (1) | DE2407904A1 (en) |
| DK (1) | DK140480B (en) |
| ES (1) | ES423817A1 (en) |
| FR (1) | FR2252091B2 (en) |
| GB (1) | GB1451724A (en) |
| HU (1) | HU169190B (en) |
| IE (1) | IE39042B1 (en) |
| IL (1) | IL44160A (en) |
| NL (1) | NL7402611A (en) |
| PH (1) | PH11140A (en) |
| PL (1) | PL98288B1 (en) |
| RO (1) | RO71304A (en) |
| SE (1) | SE416809B (en) |
| SU (1) | SU493965A3 (en) |
| YU (1) | YU49074A (en) |
| ZA (1) | ZA74758B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7186837B2 (en) | 2004-04-30 | 2007-03-06 | Resolution Chemicals | Preparation of cabergoline |
| US7238810B2 (en) | 2005-03-23 | 2007-07-03 | Parveen Bhatarah | Preparation of cabergoline |
| US7339060B2 (en) | 2005-03-23 | 2008-03-04 | Resolution Chemicals, Ltd. | Preparation of cabergoline |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0160842B1 (en) * | 1984-04-09 | 1994-06-22 | Schering Aktiengesellschaft | 2-Substituted ergoline derivatives, processes for their preparation, and their use as medicaments |
-
1973
- 1973-07-16 PH PH15493A patent/PH11140A/en unknown
-
1974
- 1974-02-05 GB GB534674A patent/GB1451724A/en not_active Expired
- 1974-02-05 ZA ZA740758A patent/ZA74758B/en unknown
- 1974-02-06 IE IE00222/74A patent/IE39042B1/en unknown
- 1974-02-06 CA CA191,927A patent/CA1011334A/en not_active Expired
- 1974-02-06 IL IL44160A patent/IL44160A/en unknown
- 1974-02-19 DE DE19742407904 patent/DE2407904A1/en not_active Withdrawn
- 1974-02-22 AR AR252504A patent/AR212072A1/en active
- 1974-02-22 AT AT146974A patent/AT333982B/en not_active IP Right Cessation
- 1974-02-26 YU YU00490/74A patent/YU49074A/en unknown
- 1974-02-26 NL NL7402611A patent/NL7402611A/en not_active Application Discontinuation
- 1974-02-27 BE BE1005751A patent/BE811610R/en active
- 1974-02-27 FR FR7406665A patent/FR2252091B2/fr not_active Expired
- 1974-02-28 SE SE7402672A patent/SE416809B/en unknown
- 1974-02-28 JP JP49022919A patent/JPS5084598A/ja active Pending
- 1974-02-28 DK DK106674AA patent/DK140480B/en unknown
- 1974-02-28 DD DD176871A patent/DD116828A6/xx unknown
- 1974-02-28 CH CH283374A patent/CH592088A5/xx not_active IP Right Cessation
- 1974-03-01 ES ES423817A patent/ES423817A1/en not_active Expired
- 1974-03-11 PL PL1974169434A patent/PL98288B1/en unknown
- 1974-03-14 HU HUEI533A patent/HU169190B/hu unknown
- 1974-03-14 SU SU2004671A patent/SU493965A3/en active
- 1974-03-14 BG BG026052A patent/BG22399A3/en unknown
- 1974-03-15 CS CS1906A patent/CS175474B2/cs unknown
- 1974-03-15 RO RO7478047A patent/RO71304A/en unknown
-
1982
- 1982-10-29 JP JP57190684A patent/JPS5888379A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7186837B2 (en) | 2004-04-30 | 2007-03-06 | Resolution Chemicals | Preparation of cabergoline |
| US7238810B2 (en) | 2005-03-23 | 2007-07-03 | Parveen Bhatarah | Preparation of cabergoline |
| US7339060B2 (en) | 2005-03-23 | 2008-03-04 | Resolution Chemicals, Ltd. | Preparation of cabergoline |
Also Published As
| Publication number | Publication date |
|---|---|
| IL44160A (en) | 1977-03-31 |
| HU169190B (en) | 1976-10-28 |
| AR212072A1 (en) | 1978-05-15 |
| NL7402611A (en) | 1975-05-30 |
| BE811610R (en) | 1974-08-27 |
| IE39042B1 (en) | 1978-07-19 |
| BG22399A3 (en) | 1977-02-20 |
| PH11140A (en) | 1977-10-27 |
| RO71304A (en) | 1981-09-24 |
| JPS5888379A (en) | 1983-05-26 |
| ZA74758B (en) | 1974-12-24 |
| IE39042L (en) | 1975-05-28 |
| DK140480C (en) | 1980-03-03 |
| JPS5084598A (en) | 1975-07-08 |
| FR2252091A2 (en) | 1975-06-20 |
| CA1011334A (en) | 1977-05-31 |
| YU49074A (en) | 1982-02-28 |
| SE416809B (en) | 1981-02-09 |
| DK140480B (en) | 1979-09-10 |
| FR2252091B2 (en) | 1978-07-28 |
| DK106674A (en) | 1975-07-28 |
| PL98288B1 (en) | 1978-04-29 |
| CH592088A5 (en) | 1977-10-14 |
| SU493965A3 (en) | 1975-11-28 |
| CS175474B2 (en) | 1977-05-31 |
| DD116828A6 (en) | 1975-12-12 |
| ES423817A1 (en) | 1976-10-16 |
| AU6531574A (en) | 1975-08-07 |
| DE2407904A1 (en) | 1975-06-05 |
| AT333982B (en) | 1976-12-27 |
| ATA146974A (en) | 1976-04-15 |
| SE7402672L (en) | 1975-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |