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GB1331513A - Polysaccharides having an anticarcinogenic effect and a method of producing them from species of basidiomycetes - Google Patents

Polysaccharides having an anticarcinogenic effect and a method of producing them from species of basidiomycetes

Info

Publication number
GB1331513A
GB1331513A GB4887070A GB1331513DA GB1331513A GB 1331513 A GB1331513 A GB 1331513A GB 4887070 A GB4887070 A GB 4887070A GB 1331513D A GB1331513D A GB 1331513DA GB 1331513 A GB1331513 A GB 1331513A
Authority
GB
United Kingdom
Prior art keywords
reaction
detecting
acid reaction
species
subjected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4887070A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Publication of GB1331513A publication Critical patent/GB1331513A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1331513 Microbial polysaccharides KUREHA KAGAKU KOGYO KK 14 Oct 1970 [15 Oct 1969] 48870/70 Heading C3U [Also in Division A5] Polysaccharides and polysaccharide-protein complexes possessing anti-carcinogenic properties are recovered from a liquid e.g. hot water, extract of a mycelium of a species of Basidiomycetes or a cultured broth of the species in a conventional fashion, after first removing free protein, free nucleic acids, reducing sugars, various ions and vitamins to give a greyish white amorphous solid characterized by the following properties: water-soluble, non-hydroscopic and non-dialyzable, gives a positive result when tested for the presence of glucose after hydrolysis with IN sulphuric acid; gives negative results when subjected to the ferric chloride reaction for determining the presence of phenols and to the Fehling reaction for determining the presence of reducing sugars; gives positive results when subjected to the anisaldehyde-sulphuric acid reaction, the Molisch reaction with α-naphthol the anthrone-sulphuric acid reaction and the tryptophanesulphuric acid reaction for detecting the presence of any saccharide, gives a positive result when subjected to the chromotropic acidsulphuric acid reaction for detecting the presence of a hexose, the aniline-hydrochloric acid reaction for detecting the presence of a pentose, the resorcinol-hydrochloric acid reaction (Seliwanoff's reaction) for detecting the presence of a ketohexose and pentose, the carbazole-cysteinesulphuric acid reaction for detecting the presence of a ketose, the Tollens reaction, and the thiogylcol-sulphuric acid reaction for detecting a ketose and uronic acid; shows only one spot at the anode side when subjected to electrophoresis in a 0À05 mol sodium borate solution for 90 minutes using a cellulose acetate membrane at 20-25 V/cm; and shows no antimicrobial action to bacteria, fungi and yeasts such as Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Aspergillus niger and Candida albicans. It is in this last respect stated to be differentiated from anti-bacterial anticarcinogenic substances obtained from species of Actinomycetes. The 19 examples describe detailed recovery procedures and specifically mention a very large number of species and strains of Basidiomycetes.
GB4887070A 1969-10-15 1970-10-14 Polysaccharides having an anticarcinogenic effect and a method of producing them from species of basidiomycetes Expired GB1331513A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8181369A JPS55363B1 (en) 1969-10-15 1969-10-15

Publications (1)

Publication Number Publication Date
GB1331513A true GB1331513A (en) 1973-09-26

Family

ID=13756923

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4887070A Expired GB1331513A (en) 1969-10-15 1970-10-14 Polysaccharides having an anticarcinogenic effect and a method of producing them from species of basidiomycetes

Country Status (8)

Country Link
JP (1) JPS55363B1 (en)
BE (1) BE757248A (en)
CA (1) CA983870A (en)
CH (1) CH587345A5 (en)
DE (1) DE2050714C2 (en)
FR (1) FR2070133B1 (en)
GB (1) GB1331513A (en)
NL (1) NL7014572A (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2713536A1 (en) * 1976-07-07 1978-01-12 Kureha Chemical Ind Co Ltd METHOD FOR THE PRODUCTION OF NITROGENOUS POLYSACCHARIDES
DE2713458A1 (en) * 1976-07-07 1978-01-19 Kureha Chemical Ind Co Ltd METHOD FOR THE PRODUCTION OF NITROGENOUS POLYSACCHARIDES
DE2803681A1 (en) * 1977-01-27 1978-08-17 Kureha Chemical Ind Co Ltd NEW POLYSACCARIDES AND METHODS FOR THEIR PRODUCTION
US4140578A (en) * 1976-07-22 1979-02-20 Kureha Kagaku Kogyo Kabushiki Kaisha Method of producing polysaccharides
US4202885A (en) * 1975-12-18 1980-05-13 Kureha Kagaku Kogyo Kabushiki Kaisha Process for the preparation of anti-transplanted sarcoma 180 tumorigenic substances
US4271151A (en) 1976-01-01 1981-06-02 Kureha Kagaku Kogyo Kabushiki Kaisha Protein-bound polysaccharides
EP0024206A3 (en) * 1979-08-16 1981-11-25 Sumitomo Chemical Company, Limited Antitumor substance, composition comprising it and process for preparing said substance
FR2485373A1 (en) * 1980-06-25 1981-12-31 Iizuka Chiyokichi ANTIVIRAL SUBSTANCE AND METHOD FOR MANUFACTURING THE SAME
EP0058093A1 (en) * 1981-02-10 1982-08-18 Kureha Kagaku Kogyo Kabushiki Kaisha Glycoprotein having anti-tumour and lectin-like activity
EP1709969A1 (en) * 2005-04-07 2006-10-11 Praktijkonderzoek Plant en Omgeving B.V. Health promoting dairy and food products containing mushroom glucan produced through fermentation of Grifola frondosa
WO2006133707A3 (en) * 2005-06-15 2007-04-12 Medimush As Anti-cancer combination treatment and kit-of-part
US7514085B2 (en) 2004-07-16 2009-04-07 Medimush A/S Immune modulating compounds from fungi
CN110117602A (en) * 2019-01-10 2019-08-13 江苏大学 Grifola frondosus UDP-glucose pyrophosphorylase and its application
CN114875174A (en) * 2022-06-28 2022-08-09 上海市农业科学院 LAMP primer group, kit and detection method for rapidly identifying russula vinosa
CN116751315A (en) * 2023-06-16 2023-09-15 安徽大学绿色产业创新研究院 Armillariella mellea mycelium homogeneous polysaccharide, and preparation method and application thereof
CN116769059A (en) * 2022-03-09 2023-09-19 东北师范大学 Fungus galactan with immunoadjuvant activity and preparation method and application thereof
CN117448350A (en) * 2023-10-18 2024-01-26 哈尔滨学院 Application of Phellinus linteus Pb-bHLH9 gene in improving multiple stress resistance of Saccharomyces cerevisiae

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356449A (en) * 1970-12-30 1974-06-12 Iizuka C Process for extracting water soluble components of the hyphae of edible fungi
JPS5366412A (en) * 1976-10-30 1978-06-13 Sato Akihiko Extracting and separating effective component of mushroom *1mannentake1*
GB1572074A (en) * 1977-03-30 1980-07-23 Kirin Seagram Ltd Chemotherapeutic substances and methods of manufacturing same
JPS5446830A (en) * 1977-09-16 1979-04-13 Kureha Chem Ind Co Ltd Pesticide for plant viral disease
JPS5542564A (en) * 1978-09-21 1980-03-25 Takara Shuzo Co Ltd Production of antitumorigenic substance
CN116062907B (en) * 2023-02-09 2024-10-01 中国科学院南京土壤研究所 Microbial degradation purification method for PAHs in water body

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA968286A (en) * 1968-03-28 1975-05-27 Nobuhiko Komatsu Process for manufacture of polysaccharides with antitumor action
CA968287A (en) * 1968-10-08 1975-05-27 Fumiko Fukuoka Antitumor polysaccharides and preparation thereof

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202885A (en) * 1975-12-18 1980-05-13 Kureha Kagaku Kogyo Kabushiki Kaisha Process for the preparation of anti-transplanted sarcoma 180 tumorigenic substances
US4289688A (en) 1976-01-01 1981-09-15 Kureha Kagaku Kogyo Kabushiki Kaisha Protein-bound polysaccharides
US4271151A (en) 1976-01-01 1981-06-02 Kureha Kagaku Kogyo Kabushiki Kaisha Protein-bound polysaccharides
DE2713458A1 (en) * 1976-07-07 1978-01-19 Kureha Chemical Ind Co Ltd METHOD FOR THE PRODUCTION OF NITROGENOUS POLYSACCHARIDES
DE2713536A1 (en) * 1976-07-07 1978-01-12 Kureha Chemical Ind Co Ltd METHOD FOR THE PRODUCTION OF NITROGENOUS POLYSACCHARIDES
US4699787A (en) * 1976-07-07 1987-10-13 Kureha Kagaku Kogyo Kabushiki Kaisha Nitrogen-containing polysaccharide
US4202969A (en) * 1976-07-07 1980-05-13 Kureha Kagaku Kogyo Kabushiki Kaisha Method of producing nitrogen-containing polysaccharides
US4140578A (en) * 1976-07-22 1979-02-20 Kureha Kagaku Kogyo Kabushiki Kaisha Method of producing polysaccharides
DE2803681A1 (en) * 1977-01-27 1978-08-17 Kureha Chemical Ind Co Ltd NEW POLYSACCARIDES AND METHODS FOR THEIR PRODUCTION
EP0024206A3 (en) * 1979-08-16 1981-11-25 Sumitomo Chemical Company, Limited Antitumor substance, composition comprising it and process for preparing said substance
FR2485373A1 (en) * 1980-06-25 1981-12-31 Iizuka Chiyokichi ANTIVIRAL SUBSTANCE AND METHOD FOR MANUFACTURING THE SAME
EP0058093A1 (en) * 1981-02-10 1982-08-18 Kureha Kagaku Kogyo Kabushiki Kaisha Glycoprotein having anti-tumour and lectin-like activity
US7514085B2 (en) 2004-07-16 2009-04-07 Medimush A/S Immune modulating compounds from fungi
US7682615B2 (en) 2004-07-16 2010-03-23 Beka Holding As Immune modulating compounds from fungi
EP1709969A1 (en) * 2005-04-07 2006-10-11 Praktijkonderzoek Plant en Omgeving B.V. Health promoting dairy and food products containing mushroom glucan produced through fermentation of Grifola frondosa
WO2006107208A3 (en) * 2005-04-07 2007-07-26 Praktijkonderzoek Plant En Omg Health promoting dairy and food products containing mushroom glucan produced through fermentation of grifola frondosa
WO2006133707A3 (en) * 2005-06-15 2007-04-12 Medimush As Anti-cancer combination treatment and kit-of-part
CN110117602A (en) * 2019-01-10 2019-08-13 江苏大学 Grifola frondosus UDP-glucose pyrophosphorylase and its application
CN110117602B (en) * 2019-01-10 2023-06-09 江苏大学 Grifola frondosa UDP-glucose pyrophosphorylase and its application
CN116769059A (en) * 2022-03-09 2023-09-19 东北师范大学 Fungus galactan with immunoadjuvant activity and preparation method and application thereof
CN114875174A (en) * 2022-06-28 2022-08-09 上海市农业科学院 LAMP primer group, kit and detection method for rapidly identifying russula vinosa
CN114875174B (en) * 2022-06-28 2023-07-07 上海市农业科学院 A LAMP primer set, kit and detection method for rapid identification of poisonous russula
CN116751315A (en) * 2023-06-16 2023-09-15 安徽大学绿色产业创新研究院 Armillariella mellea mycelium homogeneous polysaccharide, and preparation method and application thereof
CN117448350A (en) * 2023-10-18 2024-01-26 哈尔滨学院 Application of Phellinus linteus Pb-bHLH9 gene in improving multiple stress resistance of Saccharomyces cerevisiae
CN117448350B (en) * 2023-10-18 2024-05-10 哈尔滨学院 Application of Phellinus linteus Pb-bHLH9 gene to improve the multiple stress resistance of Saccharomyces cerevisiae

Also Published As

Publication number Publication date
JPS55363B1 (en) 1980-01-08
BE757248A (en) 1971-04-08
DE2050714C2 (en) 1985-09-19
NL7014572A (en) 1971-04-19
FR2070133B1 (en) 1975-03-14
CH587345A5 (en) 1977-04-29
DE2050714A1 (en) 1971-04-22
FR2070133A1 (en) 1971-09-10
CA983870A (en) 1976-02-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years