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GB1325630A - Benzodiazepine derivatives and a process for the manufacture thereof - Google Patents

Benzodiazepine derivatives and a process for the manufacture thereof

Info

Publication number
GB1325630A
GB1325630A GB5998271A GB5998271A GB1325630A GB 1325630 A GB1325630 A GB 1325630A GB 5998271 A GB5998271 A GB 5998271A GB 5998271 A GB5998271 A GB 5998271A GB 1325630 A GB1325630 A GB 1325630A
Authority
GB
United Kingdom
Prior art keywords
formula
dec
compound
manufacture
benzodiazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5998271A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1325630A publication Critical patent/GB1325630A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1325630 Benzodiazepines F HOFFMANN LA ROCHE & CO AG 23 Dec 1971 [23 Dec 1970 (2)] 59982/71 Heading C2C Compounds of the general formula (B = CH 2 CO; R 1-4 = H, C 1-6 alkyl; R 5 = H, halogen; R 6,7 = H or R 6+7 = C-N bond) and their acid addition salts are prepared by (a) reducing or treating with a C 1-6 alkyl lithium a compound of the formula or (b) cyclizing a compound of the formula optionally followed by alkylation, oxidation or reduction and/or salt formation. The above compounds are anticonvulsants, muscle relaxants and sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB5998271A 1970-12-23 1971-12-23 Benzodiazepine derivatives and a process for the manufacture thereof Expired GB1325630A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10118470A 1970-12-23 1970-12-23
US10111770A 1970-12-23 1970-12-23
US10118370A 1970-12-23 1970-12-23

Publications (1)

Publication Number Publication Date
GB1325630A true GB1325630A (en) 1973-08-08

Family

ID=27379131

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5998271A Expired GB1325630A (en) 1970-12-23 1971-12-23 Benzodiazepine derivatives and a process for the manufacture thereof

Country Status (4)

Country Link
DE (1) DE2163625A1 (en)
FR (1) FR2119071B1 (en)
GB (1) GB1325630A (en)
NL (1) NL7117761A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115536530A (en) * 2022-10-10 2022-12-30 浙江大学 A kind of chemical total synthesis method of Vulgarisin type tetracyclic diterpene compound
CN116851038A (en) * 2023-06-30 2023-10-10 河北师范大学 Magnetic nano diacid catalyst and preparation method and catalytic application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792438A (en) * 1971-12-10 1973-06-08 Hoffmann La Roche BENZODIAZEPINE DERIVATIVES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL258884A (en) * 1900-01-01

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115536530A (en) * 2022-10-10 2022-12-30 浙江大学 A kind of chemical total synthesis method of Vulgarisin type tetracyclic diterpene compound
CN116851038A (en) * 2023-06-30 2023-10-10 河北师范大学 Magnetic nano diacid catalyst and preparation method and catalytic application thereof

Also Published As

Publication number Publication date
NL7117761A (en) 1972-06-27
DE2163625A1 (en) 1972-07-13
FR2119071A1 (en) 1972-08-04
FR2119071B1 (en) 1975-03-14

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees