GB1324568A - Propionic acid and processes for its manufacture - Google Patents
Propionic acid and processes for its manufactureInfo
- Publication number
- GB1324568A GB1324568A GB2635771A GB2635771A GB1324568A GB 1324568 A GB1324568 A GB 1324568A GB 2635771 A GB2635771 A GB 2635771A GB 2635771 A GB2635771 A GB 2635771A GB 1324568 A GB1324568 A GB 1324568A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antihypertensive
- propionic acid
- agents
- april
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 235000019260 propionic acid Nutrition 0.000 title 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 3
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 abstract 2
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002220 antihypertensive agent Substances 0.000 abstract 2
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 abstract 1
- SZLZWPPUNLXJEA-UHFFFAOYSA-N 11,17-dimethoxy-18-[3-(3,4,5-trimethoxy-phenyl)-acryloyloxy]-yohimbane-16-carboxylic acid methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(OC)C1OC(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1 SZLZWPPUNLXJEA-UHFFFAOYSA-N 0.000 abstract 1
- CVBMAZKKCSYWQR-BPJCFPRXSA-N Deserpidine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cccc3 CVBMAZKKCSYWQR-BPJCFPRXSA-N 0.000 abstract 1
- 229930189630 Protoveratrine Natural products 0.000 abstract 1
- HYTGGNIMZXFORS-MGYKWWNKSA-N Protoveratrine A Chemical compound O1[C@@]([C@H](CC[C@]23C)OC(=O)[C@@](C)(O)CC)(O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@]12C[C@H]1[C@H](CN2[C@@H](CC[C@H](C)C2)[C@@]2(C)O)[C@@H]2[C@@H](O)[C@H](OC(=O)[C@H](C)CC)[C@@]31O HYTGGNIMZXFORS-MGYKWWNKSA-N 0.000 abstract 1
- SZLZWPPUNLXJEA-FMCDHCOASA-N Rescinnamine Natural products O=C(O[C@H]1[C@@H](OC)[C@@H](C(=O)OC)[C@@H]2[C@H](C1)CN1[C@@H](c3[nH]c4c(c3CC1)ccc(OC)c4)C2)/C=C/c1cc(OC)c(OC)c(OC)c1 SZLZWPPUNLXJEA-FMCDHCOASA-N 0.000 abstract 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960002155 chlorothiazide Drugs 0.000 abstract 1
- JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclopenthaiazide Chemical compound 0.000 abstract 1
- 229960001993 deserpidine Drugs 0.000 abstract 1
- ISMCNVNDWFIXLM-WCGOZPBSSA-N deserpidine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 ISMCNVNDWFIXLM-WCGOZPBSSA-N 0.000 abstract 1
- VQKLRVZQQYVIJW-UHFFFAOYSA-N dihydralazine Chemical compound C1=CC=C2C(NN)=NN=C(NN)C2=C1 VQKLRVZQQYVIJW-UHFFFAOYSA-N 0.000 abstract 1
- 229960002877 dihydralazine Drugs 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003457 ganglion blocking agent Substances 0.000 abstract 1
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 abstract 1
- 229960003602 guanethidine Drugs 0.000 abstract 1
- 229960002474 hydralazine Drugs 0.000 abstract 1
- 229960002003 hydrochlorothiazide Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960001965 rescinnamine Drugs 0.000 abstract 1
- SMSAPZICLFYVJS-QEGASFHISA-N rescinnamine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)\C=C\C1=CC(OC)=C(OC)C(OC)=C1 SMSAPZICLFYVJS-QEGASFHISA-N 0.000 abstract 1
- 229960003147 reserpine Drugs 0.000 abstract 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1324568 Antihypertensive medicines CIBAGEIGY AG 19 April 1971 [9 April 1970 16 July 1970 9 March 1971] 26357/71 Heading A5B [Also in Division C2] Pharmaceutical compositions, having antihypertensive activity contain the novel compound (+)-#-amino-#-(3,4-dimethoxyphenyl)- propionic acid or salts thereof together with pharmaceutical oxcipients and if desired other antihypertensive agents, such as alkaloids, for example reserpine, rescinnamine, deserpidine, syrusingopine, germaine or protoveratrine, or synthetic antihypertensive and / or diuretic agents such as, chlorothiazide, hydrochlorothiazide, cyclopenthaiazide, 3-(3-sulphamyl-4- chlorophenyl)-3-hydroxyisoindolin-1-one, hydralazine, dihydralazine, guanethidine, or ganglion-blocking agents such as chloroisoridamine. The compositions may be in a form suitable for an enteral, oral or parenteral administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH527370A CH554832A (en) | 1970-04-09 | 1970-04-09 | (+)-beta-amino-beta (3,4-dimethoxy-phenyl)-p - |
| CH1081970A CH551944A (en) | 1970-07-16 | 1970-07-16 | (+)-beta-amino-beta (3,4-dimethoxy-phenyl)-p - |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1324568A true GB1324568A (en) | 1973-07-25 |
Family
ID=25697355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2635771A Expired GB1324568A (en) | 1970-04-09 | 1971-04-19 | Propionic acid and processes for its manufacture |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1324568A (en) |
-
1971
- 1971-04-19 GB GB2635771A patent/GB1324568A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1173998A (en) | Novel Pyridoindole Derivatives and a Process for the Manufacture thereof | |
| GB1388358A (en) | Taste-improving formulations of oral penicillins | |
| GB1491503A (en) | Method of preventing and treating thrombosis | |
| GB1530074A (en) | Rho-acetamidophenol derivatives the preparation thereof and the use of such derivatives as therapeutic agents | |
| GB1421229A (en) | Pharmaceutical compositions comprising ergot alkaloid and vitamins | |
| GB1324568A (en) | Propionic acid and processes for its manufacture | |
| IE34648L (en) | Pharmaceutical composition containing garcinia acid | |
| GB1261989A (en) | 5-thiazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing the same | |
| IE35507B1 (en) | Anti-inflammatory preparations containing tetrahydrocarbazole derivatives | |
| GB1394757A (en) | Lysino-calcium chloride | |
| IE35711B1 (en) | Pharmaceutical composition for inhibiting indoleamine-n-methyl transferase | |
| GB1178012A (en) | A Method for the Production of Pyridine Derivatives | |
| GB1339969A (en) | Aminopropionic acid derivatives and process for their manufacture | |
| IE33519B1 (en) | Novel benzyl-hydrazide derivatives and a process for the manufacture thereof and novel benzylidene-hydrazide derivatives useful in said process | |
| IE36255B1 (en) | A tripeptide and acid addition salts thereof and a process for the manufacture of same | |
| GB1397675A (en) | Proline compounds | |
| IE33520B1 (en) | Novel benzyl-hydrazide derivatives and a process for the manufacture thereof and novel benzylidene-hydrazide derivatives useful in said process | |
| GB1501839A (en) | Pharmaceutical compositions for the inhibition of thrombocyte aggregation | |
| ES374270A1 (en) | 3-n-(2 - hydroxy-3-phenoxypropyl)-amino-1-phenylpropanon-(1) and the salts thereof | |
| GB1176721A (en) | 0-Cyclopentenecarboxylic Acids and Process for their Manufacture | |
| GB1312196A (en) | Nicotinic acid derivatives and a process for the manufacture thereof | |
| GB1294538A (en) | Pharmaceutical compositions | |
| GB1429923A (en) | Isoxazole derivatives and the production thereof | |
| GB1256735A (en) | ||
| GB1392004A (en) | Propoxyphene salts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |