GB1323377A - Antibiotic complexes - Google Patents
Antibiotic complexesInfo
- Publication number
- GB1323377A GB1323377A GB4951871A GB4951871A GB1323377A GB 1323377 A GB1323377 A GB 1323377A GB 4951871 A GB4951871 A GB 4951871A GB 4951871 A GB4951871 A GB 4951871A GB 1323377 A GB1323377 A GB 1323377A
- Authority
- GB
- United Kingdom
- Prior art keywords
- syntan
- formaldehyde
- antibiotic
- complex
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 7
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- SQAINHDHICKHLX-UHFFFAOYSA-N 1-naphthaldehyde Chemical class C1=CC=C2C(C=O)=CC=CC2=C1 SQAINHDHICKHLX-UHFFFAOYSA-N 0.000 abstract 1
- IULJSGIJJZZUMF-UHFFFAOYSA-N 2-hydroxybenzenesulfonic acid Chemical compound OC1=CC=CC=C1S(O)(=O)=O IULJSGIJJZZUMF-UHFFFAOYSA-N 0.000 abstract 1
- VPWNQTHUCYMVMZ-UHFFFAOYSA-N 4,4'-sulfonyldiphenol Chemical class C1=CC(O)=CC=C1S(=O)(=O)C1=CC=C(O)C=C1 VPWNQTHUCYMVMZ-UHFFFAOYSA-N 0.000 abstract 1
- 229930185605 Bisphenol Natural products 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000007605 air drying Methods 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 150000001896 cresols Chemical class 0.000 abstract 1
- 239000011363 dried mixture Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000006052 feed supplement Substances 0.000 abstract 1
- 239000008098 formaldehyde solution Substances 0.000 abstract 1
- -1 formaldehyde, phenols Chemical class 0.000 abstract 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical class O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 abstract 1
- 150000004780 naphthols Chemical class 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G16/00—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00
- C08G16/02—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes
- C08G16/0212—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes with acyclic or carbocyclic organic compounds
- C08G16/0218—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes with acyclic or carbocyclic organic compounds containing atoms other than carbon and hydrogen
- C08G16/0237—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes with acyclic or carbocyclic organic compounds containing atoms other than carbon and hydrogen containing sulfur
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
- C08G8/04—Condensation polymers of aldehydes or ketones with phenols only of aldehydes
- C08G8/08—Condensation polymers of aldehydes or ketones with phenols only of aldehydes of formaldehyde, e.g. of formaldehyde formed in situ
- C08G8/18—Condensation polymers of aldehydes or ketones with phenols only of aldehydes of formaldehyde, e.g. of formaldehyde formed in situ with phenols substituted by carboxylic or sulfonic acid groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
- C08G8/28—Chemically modified polycondensates
Landscapes
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Feed For Specific Animals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1323377 Complexes of antibiotic AV290; sulphonic acids AMERICAN CYANAMID CO 25 Oct 1971 [3 Nov 1970] 49518/71 Headings C2A and C2C [Also in Division C3] Novel complexes of antibiotic AV290 and a syntan are prepared by acidifying a whole or filtered AV290-containing fermentation broth to pH 1À4 to 5À0, adding a syntan and recovering the precipitated complex. Syntans are defined as synthetic tanning agents which are condensation products of formaldehyde and sulphonated phenols (e.g. phenol, cresols, naphthols or bis-phenols) or naphthalene-sulphonic acids, or of formaldehyde, phenols and a bisulphite or SO 2 (see Division C3). The complexes are recovered by filtration or centrifugation and when a whole fermentation broth is used, they are obtained in the form of a composition of the complex together with the broth solids (e.g. mycelia and other insoluble matter), which is then dried, for example by reslurrying in water and freeze-drying or spraydrying, or by slurrying in a water-miscible organic non-solvent (e.g. acetone), filtering and air-drying. The syntan is preferably added as an aqueous solution, in slight excess of amount required to completely precipitate the complex. The antibiotic is loosely bonded to the syntan and may be isolated therefrom by absorption on cross-linked carboxymethyldextran gel and eluting with aqueous acid. Animal feed supplement compositions having growth-promoting and feed efficiency-enhancing activity comprise a dried mixture of fermentation broth solids and the antibiotic AV290- syntan complex, optionally together with an edible carrier and/or a nutritionally balanced animal feed. A sulphonated naphthalene-formaldehyde condensate probably having the formula wherein n is zero to 4, is prepared by sulphonating naphthalene at 105 C. with 93% H 2 SO 4 and treating the reaction mixture with aqueous formaldehyde. A sulphonated phenol-formaldehyde condensate probably having the formula: wherein R is -SO 3 H and n is zero to 4, is prepared by reacting phenolsulphonic acid and aqueous formaldehyde solution at 100 C. and then cooling to precipitate the said product. Reference has been directed by the Comptroller to Specification 1,194,365.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8660170A | 1970-11-03 | 1970-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1323377A true GB1323377A (en) | 1973-07-11 |
Family
ID=22199652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4951871A Expired GB1323377A (en) | 1970-11-03 | 1971-10-25 | Antibiotic complexes |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS551025B1 (en) |
| AR (1) | AR192327A1 (en) |
| AT (1) | AT324108B (en) |
| AU (1) | AU463112B2 (en) |
| BE (1) | BE774817A (en) |
| CA (1) | CA983015A (en) |
| CH (1) | CH554645A (en) |
| DE (1) | DE2154633C3 (en) |
| DK (1) | DK141475B (en) |
| ES (1) | ES396596A1 (en) |
| FR (1) | FR2113392A5 (en) |
| GB (1) | GB1323377A (en) |
| HU (1) | HU163819B (en) |
| IE (1) | IE35741B1 (en) |
| IL (1) | IL37978A (en) |
| IT (1) | IT1050190B (en) |
| MY (1) | MY7400223A (en) |
| NL (1) | NL167469C (en) |
| PH (1) | PH9247A (en) |
| SE (1) | SE378170B (en) |
| YU (1) | YU35953B (en) |
| ZA (1) | ZA716946B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD114342A5 (en) * | 1973-04-27 | 1975-08-05 | ||
| DE3005642A1 (en) | 1980-02-15 | 1981-08-20 | Hoechst Ag, 6000 Frankfurt | SOLID OF THE SALINOMYCIN CULTURAL BROTH AND METHOD FOR ITS PRODUCTION |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3338786A (en) * | 1966-07-29 | 1967-08-29 | American Cyanamid Co | Antibiotic av290 and production thereof |
-
1971
- 1971-10-18 ZA ZA716946A patent/ZA716946B/en unknown
- 1971-10-18 IE IE1305/71A patent/IE35741B1/en unknown
- 1971-10-20 AU AU34788/71A patent/AU463112B2/en not_active Expired
- 1971-10-21 IL IL37978A patent/IL37978A/en unknown
- 1971-10-22 PH PH12958*UA patent/PH9247A/en unknown
- 1971-10-25 GB GB4951871A patent/GB1323377A/en not_active Expired
- 1971-10-26 CA CA126,145A patent/CA983015A/en not_active Expired
- 1971-10-28 AR AR238729A patent/AR192327A1/en active
- 1971-10-29 DK DK530971AA patent/DK141475B/en not_active IP Right Cessation
- 1971-10-29 FR FR7138954A patent/FR2113392A5/fr not_active Expired
- 1971-11-02 HU HUAE344A patent/HU163819B/hu unknown
- 1971-11-02 SE SE7113955A patent/SE378170B/xx unknown
- 1971-11-02 IT IT53837/71A patent/IT1050190B/en active
- 1971-11-02 YU YU2772/71A patent/YU35953B/en unknown
- 1971-11-03 NL NL7115137.A patent/NL167469C/en not_active IP Right Cessation
- 1971-11-03 DE DE2154633A patent/DE2154633C3/en not_active Expired
- 1971-11-03 AT AT946771A patent/AT324108B/en not_active IP Right Cessation
- 1971-11-03 BE BE774817A patent/BE774817A/en not_active IP Right Cessation
- 1971-11-03 ES ES396596A patent/ES396596A1/en not_active Expired
- 1971-11-03 CH CH1602071A patent/CH554645A/en not_active IP Right Cessation
- 1971-11-04 JP JP8796971A patent/JPS551025B1/ja active Pending
-
1974
- 1974-12-30 MY MY223/74A patent/MY7400223A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR192327A1 (en) | 1973-02-14 |
| ZA716946B (en) | 1972-06-28 |
| DE2154633A1 (en) | 1972-05-04 |
| FR2113392A5 (en) | 1972-06-23 |
| ES396596A1 (en) | 1974-12-16 |
| AU463112B2 (en) | 1975-07-17 |
| AU3478871A (en) | 1973-05-03 |
| HU163819B (en) | 1973-11-28 |
| IT1050190B (en) | 1981-03-10 |
| MY7400223A (en) | 1974-12-31 |
| IE35741B1 (en) | 1976-05-12 |
| IL37978A (en) | 1974-05-16 |
| DE2154633B2 (en) | 1981-07-30 |
| JPS551025B1 (en) | 1980-01-11 |
| AT324108B (en) | 1975-08-11 |
| DK141475C (en) | 1980-08-25 |
| IL37978A0 (en) | 1971-12-29 |
| CA983015A (en) | 1976-02-03 |
| NL167469C (en) | 1981-12-16 |
| CH554645A (en) | 1974-10-15 |
| YU35953B (en) | 1981-11-13 |
| YU277271A (en) | 1981-04-30 |
| NL7115137A (en) | 1972-05-05 |
| NL167469B (en) | 1981-07-16 |
| DK141475B (en) | 1980-03-24 |
| BE774817A (en) | 1972-05-03 |
| SE378170B (en) | 1975-08-25 |
| IE35741L (en) | 1972-05-03 |
| PH9247A (en) | 1975-07-30 |
| DE2154633C3 (en) | 1982-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |