GB1399887A - Composition and methods for controlling collagen synthesis - Google Patents
Composition and methods for controlling collagen synthesisInfo
- Publication number
- GB1399887A GB1399887A GB2548472A GB2548472A GB1399887A GB 1399887 A GB1399887 A GB 1399887A GB 2548472 A GB2548472 A GB 2548472A GB 2548472 A GB2548472 A GB 2548472A GB 1399887 A GB1399887 A GB 1399887A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allo
- proline
- lysine
- hydroxy
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000008186 Collagen Human genes 0.000 title abstract 3
- 108010035532 Collagen Proteins 0.000 title abstract 3
- 229920001436 collagen Polymers 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- OMGHIGVFLOPEHJ-BYPYZUCNSA-N (2s)-2,5-dihydro-1h-pyrrole-2-carboxylic acid Chemical compound OC(=O)[C@H]1NCC=C1 OMGHIGVFLOPEHJ-BYPYZUCNSA-N 0.000 abstract 1
- XDEFUBWPXAOAME-OWOJBTEDSA-N (e)-2,6-diaminohex-4-enoic acid Chemical compound NC\C=C\CC(N)C(O)=O XDEFUBWPXAOAME-OWOJBTEDSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 230000006790 cellular biosynthetic process Effects 0.000 abstract 1
- PMMYEEVYMWASQN-IMJSIDKUSA-N cis-4-Hydroxy-L-proline Chemical compound O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- YSMODUONRAFBET-WHFBIAKZSA-N threo-5-hydroxy-L-lysine Chemical compound NC[C@@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-WHFBIAKZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
1399887 Controlling collagen synthesis D J PROCKOP 31 May 1972 [10 June 1971] 25484/72 Heading A5B Compositions for the control of the cellular synthesis of collagen in animals comprise an active ingredient selected from L-azetidine2-2 carboxylic acid, cis-4-hydroxy-L-proline, 3, 4- dehydro-L-proline, 2, 6-diamino-4-hexenoic acid, allo-5-fiuorohydroxy-L-lysine, allo-5- hydroxy-L-lysine and the laevo and cis isomers of compounds of the general structural formula Wherein R is OH, Cl, F, NH 2 , CH 3 , OC(O)CH 3 , OC(O)CN 2 CH 3 , SH, SOH3, OCH 3 , ONO 2 , OSO 3 H, H 2 PO 4 or COOH and a liquid or solid pharmaceutically acceptable carrier or diluent. The compositions may be administered orally, parenterally or locally in the form of tablets, powders, capsules, suspensions, solutions or emulsions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15198671A | 1971-06-10 | 1971-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1399887A true GB1399887A (en) | 1975-07-02 |
Family
ID=22541106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2548472A Expired GB1399887A (en) | 1971-06-10 | 1972-05-31 | Composition and methods for controlling collagen synthesis |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE784650A (en) |
| DE (1) | DE2228187A1 (en) |
| FR (1) | FR2140598B1 (en) |
| GB (1) | GB1399887A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2171302A (en) * | 1984-11-05 | 1986-08-28 | Dr Wilhelm Hoerrmann | Therapeutic hydroxyprolines |
| WO1987004925A1 (en) * | 1986-02-18 | 1987-08-27 | Biota Scientific Management Pty. Ltd. | Stimulation of angiogenesis |
| GB2226759A (en) * | 1987-12-30 | 1990-07-11 | Wilhelm Hoerrmann | Pharmaceutical compositions containing lysine |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4428939A (en) * | 1981-10-16 | 1984-01-31 | Prockop Darwin J | Collagen inhibiting compositions and processes for manufacturing and using same |
| GB8514075D0 (en) * | 1985-06-04 | 1985-07-10 | Shell Int Research | Therapeutic compounds |
-
1972
- 1972-05-31 GB GB2548472A patent/GB1399887A/en not_active Expired
- 1972-06-09 FR FR7220753A patent/FR2140598B1/fr not_active Expired
- 1972-06-09 DE DE19722228187 patent/DE2228187A1/en active Pending
- 1972-06-09 BE BE784650A patent/BE784650A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2171302A (en) * | 1984-11-05 | 1986-08-28 | Dr Wilhelm Hoerrmann | Therapeutic hydroxyprolines |
| GB2171302B (en) * | 1984-11-05 | 1989-08-23 | Hoerrmann Wilhelm | Tumour therapy |
| WO1987004925A1 (en) * | 1986-02-18 | 1987-08-27 | Biota Scientific Management Pty. Ltd. | Stimulation of angiogenesis |
| GB2226759A (en) * | 1987-12-30 | 1990-07-11 | Wilhelm Hoerrmann | Pharmaceutical compositions containing lysine |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2228187A1 (en) | 1972-12-14 |
| BE784650A (en) | 1972-12-11 |
| FR2140598B1 (en) | 1975-11-28 |
| FR2140598A1 (en) | 1973-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |