GB1394701A - Pharmacologically active isoquinoline derivatives - Google Patents
Pharmacologically active isoquinoline derivativesInfo
- Publication number
- GB1394701A GB1394701A GB5458272A GB5458272A GB1394701A GB 1394701 A GB1394701 A GB 1394701A GB 5458272 A GB5458272 A GB 5458272A GB 5458272 A GB5458272 A GB 5458272A GB 1394701 A GB1394701 A GB 1394701A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkylamino
- nov
- prepared
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 2
- MGZGPQCRWVOGFE-UHFFFAOYSA-N 2,4-dihydro-1h-isoquinolin-3-one Chemical compound C1=CC=C2CNC(=O)CC2=C1 MGZGPQCRWVOGFE-UHFFFAOYSA-N 0.000 abstract 1
- BJBZDVJEJGGSIV-UHFFFAOYSA-N 3-ethoxy-1,4-dihydroisoquinoline Chemical compound C1=CC=C2CC(OCC)=NCC2=C1 BJBZDVJEJGGSIV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1394701 3-(mono- or di - alkylamino)alkylamino - 1,4 - dihydroisoquinolines ASPRONICHOLAS Ltd 23 Nov 1973 [25 Nov 1972] 54582/72 Heading C2C The invention comprises the title compounds (which may contain additional therapeutically compatible substituents on the nucleus, or on the ring-attached N atom) and their acid addition salts and quaternary ammonium derivatives. Also included are compounds containing unsaturated analogues of the alkyl or alkylene groups present as essential or optional substituents. These compounds are prepared by reacting the appropriate aminoalkylamine with, e.g. 3 - ethoxy - 1,4 - dihydroisoquinoline. Also prepared is 3-oxo-1,2,3,4-tetrahydroisoquinoline. Therapeutic compositions having cardiovascular and especially anti-arrhythmic activity comprise the title compounds, and may be administered orally, parenterally or rectally.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5458272A GB1394701A (en) | 1972-11-25 | 1972-11-25 | Pharmacologically active isoquinoline derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5458272A GB1394701A (en) | 1972-11-25 | 1972-11-25 | Pharmacologically active isoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1394701A true GB1394701A (en) | 1975-05-21 |
Family
ID=10471476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5458272A Expired GB1394701A (en) | 1972-11-25 | 1972-11-25 | Pharmacologically active isoquinoline derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1394701A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
-
1972
- 1972-11-25 GB GB5458272A patent/GB1394701A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |