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GB1390542A - Anti-inflammatory compositions - Google Patents

Anti-inflammatory compositions

Info

Publication number
GB1390542A
GB1390542A GB1638672A GB1638672A GB1390542A GB 1390542 A GB1390542 A GB 1390542A GB 1638672 A GB1638672 A GB 1638672A GB 1638672 A GB1638672 A GB 1638672A GB 1390542 A GB1390542 A GB 1390542A
Authority
GB
United Kingdom
Prior art keywords
cellulose
poly
amino
anhydride
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1638672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Kagaku Yakuhin KK
Original Assignee
Otsuka Kagaku Yakuhin KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Kagaku Yakuhin KK filed Critical Otsuka Kagaku Yakuhin KK
Publication of GB1390542A publication Critical patent/GB1390542A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

1390542 Anti-inflammatory compositions OTSUKA KAGAKU YAKUHIN KK 10 April 1972 [14 April 1971] 16386/72 Heading A5B [Also in Division C3] An anti-inflammatory composition comprises (a) a water-insoluble modified protease consisting of a protease bonded to a polymer of 20,000-200,000 molecular weight which is a poly (amino acid), a polysaccharide, polyaminostyrene or a copolymer of ethylene and maleic acid or anhydride and (b) a carrier, there being no water-soluble protease present. Poly (amino acids) specified include a copolymer of L-leucine and p-amino -D, L-phenyl alanine, poly (N-carboxy-γ- methyl-glutamic anhydride), poly (N-carboxy-γ-methyl-tyrosine anhydride) and poly (N-carboxy-tyrosine anhydride). Polysaccharides specified include cellulose, diethylaminoethyl cellulose, p-amino benzyl cellulose, maminoanisole cellulose, m-aminobenzoyloxymethyl cellulose, 3-(p-amino-m-methylanilino- 5-chloro)-1-triacetyno cellulose, bromoacetyl cellulose, cellulose citrate, dextran, diethylaminoethyl dextran and dextran isocyanate. Proteases specified include trypsin, pepsin, chymotrypsin, pancreatin, bromelin, papain, and those derived from the microorganisms: Aspergillus melleus, Aspergillus oryzae, Penicillium notatum, Rhizopus chinensis, Mucor racemosis, Trametes sanguinea, Llodella subpiliata, Bacillus subtilis, Pseudomonas myxogene, Streptomyces griseus Streptomyces fradiase. The protease may be modified by reaction with the monomer of the desired polymer.
GB1638672A 1971-04-14 1972-04-10 Anti-inflammatory compositions Expired GB1390542A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2400571A JPS5443074B1 (en) 1971-04-14 1971-04-14

Publications (1)

Publication Number Publication Date
GB1390542A true GB1390542A (en) 1975-04-16

Family

ID=12126433

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1638672A Expired GB1390542A (en) 1971-04-14 1972-04-10 Anti-inflammatory compositions

Country Status (3)

Country Link
JP (1) JPS5443074B1 (en)
DE (1) DE2218162A1 (en)
GB (1) GB1390542A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045285A1 (en) * 1980-07-01 1982-02-03 Etablissement TEXCONTOR Non absorbable compounds of mucolytic activity, the process for their preparation and therapeutic compositions which contain them as active principle
GB2240040A (en) * 1990-01-04 1991-07-24 Vnii Textil Galanterey Promy Immobilised enzyme-containing wound dressings
WO2003027154A1 (en) * 2001-09-26 2003-04-03 Smith & Nephew Plc Polymers with structure-defined functions
WO2004100981A1 (en) * 2003-05-14 2004-11-25 Mucos Pharma Gmbh & Co. One or several enzyme-containing compounds, dietetic food products and drugs produced from said compounds and the use therefor for medical purposes
US7998476B2 (en) 2006-11-22 2011-08-16 Standard Biologics, Inc. Method of treatment using Aspergillus oryzae protease
US8956624B2 (en) 2007-12-19 2015-02-17 Elc Management, Llc Compositions and methods for treating skin with extract from Trametes
US9771570B2 (en) 2012-09-05 2017-09-26 Novozymes A/S Polypeptides having protease activity
CN114224980A (en) * 2020-09-08 2022-03-25 上海市同仁医院 A composition for external application

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4120971A (en) 1977-03-01 1978-10-17 Merck & Co., Inc. Novel N-carboxy-alpha-amino acid anhydrides
JPS58189122A (en) * 1982-04-30 1983-11-04 Kaken Pharmaceut Co Ltd Hyperlipidemia prevention and treatment agent

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045285A1 (en) * 1980-07-01 1982-02-03 Etablissement TEXCONTOR Non absorbable compounds of mucolytic activity, the process for their preparation and therapeutic compositions which contain them as active principle
US4409138A (en) 1980-07-01 1983-10-11 Etablissement Texcontor Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle
US4559322A (en) * 1980-07-01 1985-12-17 Etablissement Texcontor Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle
GB2240040A (en) * 1990-01-04 1991-07-24 Vnii Textil Galanterey Promy Immobilised enzyme-containing wound dressings
AU2002329421B2 (en) * 2001-09-26 2008-09-25 Smith & Nephew Plc Polymers with structure-defined functions
WO2003027154A1 (en) * 2001-09-26 2003-04-03 Smith & Nephew Plc Polymers with structure-defined functions
US7955594B2 (en) * 2001-09-26 2011-06-07 Smith & Nephew, Plc Polymers with structure-defined functions
WO2004100981A1 (en) * 2003-05-14 2004-11-25 Mucos Pharma Gmbh & Co. One or several enzyme-containing compounds, dietetic food products and drugs produced from said compounds and the use therefor for medical purposes
US7998476B2 (en) 2006-11-22 2011-08-16 Standard Biologics, Inc. Method of treatment using Aspergillus oryzae protease
US8956624B2 (en) 2007-12-19 2015-02-17 Elc Management, Llc Compositions and methods for treating skin with extract from Trametes
US9771570B2 (en) 2012-09-05 2017-09-26 Novozymes A/S Polypeptides having protease activity
US10006017B2 (en) 2012-09-05 2018-06-26 Novozymes A/S Animal feed additives comprising a protease and methods of using
US10563188B2 (en) 2012-09-05 2020-02-18 Novozymes A/S Polypeptides having protease activity
CN114224980A (en) * 2020-09-08 2022-03-25 上海市同仁医院 A composition for external application

Also Published As

Publication number Publication date
DE2218162A1 (en) 1972-11-02
JPS5443074B1 (en) 1979-12-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee