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GB1390015A - 4-amino-quinazoline compounds - Google Patents

4-amino-quinazoline compounds

Info

Publication number
GB1390015A
GB1390015A GB4784974A GB4784974A GB1390015A GB 1390015 A GB1390015 A GB 1390015A GB 4784974 A GB4784974 A GB 4784974A GB 4784974 A GB4784974 A GB 4784974A GB 1390015 A GB1390015 A GB 1390015A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
alkoxy
hydrogen
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4784974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB1380271A priority Critical patent/GB1390014A/en
Priority to GB4784974A priority patent/GB1390015A/en
Priority to AU41937/72A priority patent/AU466496B2/en
Priority to CH671672A priority patent/CH589068A5/xx
Priority to FR7216199A priority patent/FR2139863B1/fr
Priority to LU65299D priority patent/LU65299A1/xx
Priority to NL7206067A priority patent/NL7206067A/xx
Priority to SE7205960A priority patent/SE406197B/en
Priority to AT391372A priority patent/AT318620B/en
Priority to DE19722222231 priority patent/DE2222231A1/en
Priority to BE783119A priority patent/BE783119A/en
Priority to CA141,393A priority patent/CA974521A/en
Publication of GB1390015A publication Critical patent/GB1390015A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1390015 4-Aminoquinazoline compounds KONINKLIJKE PHARMACEUTISCHE FABRIEKEN NV 5 May 1972 [7 May 1971] 47849/74 Divided out of 1390014 Heading C2C Novel compounds of the Formula I wherein R 3 is a nitrogen-, oxygen-, or sulphurcontaining saturated or unsaturated mononuclear-heterocyclic group attached to the quinazoline nucleus through carbon, which may carry one or more halogens alkyls or alkoxys and/or when it contains an acylatable nitrogen, an N-acyl substituent, and the symbols R 4 to R 7 each are hydrogen, halogen, alkyl or alkoxy, the total number of carbon atoms in alkyl or alkoxy groups, when present, being not more than eight, and in which all alkyl and alkoxy radicals contain up to eight carbon atoms, with the proviso that when all of R 4 to R 7 are hydrogen, R 3 may not be 2-furyl, and acid addition and quaternary ammonium salts thereof may be prepared by the process claimed in Specification 1,390,014. Pharmaceutical compositions of the compounds I or salts thereof when administered orally or parenterally with the usual excipients or mixed in the feedstock show activity against pleuropneumonia-like organisms and other gram negative bacteria and also exert antihypertensive activity.
GB4784974A 1971-05-07 1971-05-07 4-amino-quinazoline compounds Expired GB1390015A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB1380271A GB1390014A (en) 1971-05-07 1971-05-07 Process for the preparation of carbocyclic fused pyrimidine derivatives
GB4784974A GB1390015A (en) 1971-05-07 1971-05-07 4-amino-quinazoline compounds
AU41937/72A AU466496B2 (en) 1971-05-07 1972-05-04 Pyrimidine derivatives
CH671672A CH589068A5 (en) 1971-05-07 1972-05-05
FR7216199A FR2139863B1 (en) 1971-05-07 1972-05-05
LU65299D LU65299A1 (en) 1971-05-07 1972-05-05
NL7206067A NL7206067A (en) 1971-05-07 1972-05-05
SE7205960A SE406197B (en) 1971-05-07 1972-05-05 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4-AMINOKINAZOLINE DERIVATIVES
AT391372A AT318620B (en) 1971-05-07 1972-05-05 Process for the preparation of pyrimidine derivatives and their salts
DE19722222231 DE2222231A1 (en) 1971-05-07 1972-05-05 PROCESS FOR THE MANUFACTURING OF PYRIMIDE DERIVATIVES AND THEIR ACID ADDITION SALTS AND QUARTAR AMMONIUM SALTS AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS
BE783119A BE783119A (en) 1971-05-07 1972-05-05 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES
CA141,393A CA974521A (en) 1971-05-07 1972-05-05 4-amino quinazolines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1380271A GB1390014A (en) 1971-05-07 1971-05-07 Process for the preparation of carbocyclic fused pyrimidine derivatives
GB4784974A GB1390015A (en) 1971-05-07 1971-05-07 4-amino-quinazoline compounds

Publications (1)

Publication Number Publication Date
GB1390015A true GB1390015A (en) 1975-04-09

Family

ID=26250021

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1380271A Expired GB1390014A (en) 1971-05-07 1971-05-07 Process for the preparation of carbocyclic fused pyrimidine derivatives
GB4784974A Expired GB1390015A (en) 1971-05-07 1971-05-07 4-amino-quinazoline compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1380271A Expired GB1390014A (en) 1971-05-07 1971-05-07 Process for the preparation of carbocyclic fused pyrimidine derivatives

Country Status (11)

Country Link
AT (1) AT318620B (en)
AU (1) AU466496B2 (en)
BE (1) BE783119A (en)
CA (1) CA974521A (en)
CH (1) CH589068A5 (en)
DE (1) DE2222231A1 (en)
FR (1) FR2139863B1 (en)
GB (2) GB1390014A (en)
LU (1) LU65299A1 (en)
NL (1) NL7206067A (en)
SE (1) SE406197B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377399A1 (en) * 1977-01-17 1978-08-11 Warner Lambert Co NEW COMPOUNDS OF THE QUINAZOLINE FAMILY AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
WO1994005628A1 (en) * 1992-08-31 1994-03-17 Acic (Canada) Inc. Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor
WO1999032460A1 (en) * 1997-12-18 1999-07-01 Aventis Pharma Deutschland Gmbh Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
RU2207581C2 (en) * 2001-04-17 2003-06-27 Марийский государственный университет Method determining state of line insulation of distribution networks and location of point of its failure
WO2013003586A1 (en) * 2011-06-29 2013-01-03 Otsuka Pharmaceutical Co., Ltd. Quinazolines as therapeutic compounds and related methods of use

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461194A (en) 1977-10-21 1979-05-17 Takeda Chem Ind Ltd Preparation of n22substituted 2*66diaminonebularin
AU5118979A (en) 1978-10-16 1980-04-24 Takeda Chemical Industries Ltd. 2,6-diaminoebularines
FI67699C (en) * 1979-01-31 1985-05-10 Orion Yhtymae Oy PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN
AU572585B2 (en) * 1983-09-29 1988-05-12 Akzo N.V. Quinazoline and isoquinoline derivatives
LU88789I2 (en) * 1985-09-12 1996-11-05 Upjohn Co Tirilazad mesylate and its pharmaceutically acceptable derivatives (Freedox (R))
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
US5506354A (en) * 1985-09-12 1996-04-09 The Upjohn Company Imidazolylpiperazinyl steroids
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
EP0360936A1 (en) * 1988-09-29 1990-04-04 Siemens Aktiengesellschaft Österreich Method for the conversion of a sampled analog input signal
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
WO1992007844A1 (en) * 1990-11-06 1992-05-14 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
US5536725A (en) * 1993-08-25 1996-07-16 Fmc Corporation Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines
GB2295387A (en) * 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
AR037641A1 (en) 2001-12-05 2004-11-17 Tularik Inc INFLAMMATION MODULATORS
CN116444501B (en) * 2023-04-07 2025-06-10 河北康泰药业有限公司 Quinazoline derivative, preparation method thereof, pharmaceutical composition and application

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377399A1 (en) * 1977-01-17 1978-08-11 Warner Lambert Co NEW COMPOUNDS OF THE QUINAZOLINE FAMILY AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
WO1994005628A1 (en) * 1992-08-31 1994-03-17 Acic (Canada) Inc. Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor
US5675006A (en) * 1992-08-31 1997-10-07 Brantford Chemicals Inc. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
US5686612A (en) * 1992-08-31 1997-11-11 Brantford Chemicals Inc. Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof
US6080860A (en) * 1992-08-31 2000-06-27 Brantford Chemicalss Inc. Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
WO1999032460A1 (en) * 1997-12-18 1999-07-01 Aventis Pharma Deutschland Gmbh Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
US6613772B1 (en) 1997-12-18 2003-09-02 Aventis Pharma Deutschland Gmbh Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
RU2207581C2 (en) * 2001-04-17 2003-06-27 Марийский государственный университет Method determining state of line insulation of distribution networks and location of point of its failure
WO2013003586A1 (en) * 2011-06-29 2013-01-03 Otsuka Pharmaceutical Co., Ltd. Quinazolines as therapeutic compounds and related methods of use

Also Published As

Publication number Publication date
LU65299A1 (en) 1972-08-23
DE2222231A1 (en) 1974-06-27
FR2139863B1 (en) 1975-10-31
FR2139863A1 (en) 1973-01-12
CH589068A5 (en) 1977-06-30
AU4193772A (en) 1973-11-08
AU466496B2 (en) 1975-10-30
CA974521A (en) 1975-09-16
SE406197B (en) 1979-01-29
NL7206067A (en) 1972-11-09
BE783119A (en) 1972-11-06
AT318620B (en) 1974-11-11
GB1390014A (en) 1975-04-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee