[go: up one dir, main page]

GB1379005A - 2,6-diaminodihydropyridines their production and their medicinal use - Google Patents

2,6-diaminodihydropyridines their production and their medicinal use

Info

Publication number
GB1379005A
GB1379005A GB1075973A GB1075973A GB1379005A GB 1379005 A GB1379005 A GB 1379005A GB 1075973 A GB1075973 A GB 1075973A GB 1075973 A GB1075973 A GB 1075973A GB 1379005 A GB1379005 A GB 1379005A
Authority
GB
United Kingdom
Prior art keywords
alkyl
radical
chain
march
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1075973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1379005A publication Critical patent/GB1379005A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

1379005 Dihydropyridines BAYER AG 6 March 1973 [6 March 1972 12 Sept 1972] 10759/73 Heading C2C The invention comprises novel compounds of the tautomeric formulae in which R is a saturated or unsaturated, straight-chain, branched or cyclic hydrocarbon radical, or an aryl radical optionally carrying 1, 2 or 3 identical or different substitutents selected from aryl, alkyl, alkoxy, azido, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and -SO n -Alkyl (in which n = 0, 1 or 2) radicals, or a naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl radical optionally carrying at least one substituent selected from alkyl, alkoxy and halogen radicals; and R<SP>1</SP> and R<SP>2</SP> which can be the same or different, are each a radical -OR<SP>1</SP> in which R<SP>1</SP> is a straight-chain, branched or cyclic, saturated or unsaturated aliphatic hydrocarbon radical the carbon chain of which may be interrupted by 1 or 2 oxygen atoms, or an amino, alkylamino, or dialkylamino group. They are made by reacting an amidine of formula with RCHO or with an ylidene cyanoacetic acid derivative of formula R<SP>1</SP>OC-C(.CN)(:CHR). Pharmaceutical preparations especially useful as coronary and anti-hypertensive agents contain the novel compounds as active ingredients; standard administration forms are described.
GB1075973A 1972-03-06 1973-03-06 2,6-diaminodihydropyridines their production and their medicinal use Expired GB1379005A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2210687A DE2210687C3 (en) 1972-03-06 1972-03-06 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them

Publications (1)

Publication Number Publication Date
GB1379005A true GB1379005A (en) 1975-01-02

Family

ID=5838037

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1075973A Expired GB1379005A (en) 1972-03-06 1973-03-06 2,6-diaminodihydropyridines their production and their medicinal use

Country Status (24)

Country Link
JP (2) JPS5626659B2 (en)
KR (1) KR780000119B1 (en)
AT (3) AT327904B (en)
BE (1) BE796279A (en)
BG (2) BG20583A3 (en)
CA (1) CA988524A (en)
CH (2) CH580589A5 (en)
CS (2) CS182792B2 (en)
DD (1) DD106833A5 (en)
DE (1) DE2210687C3 (en)
DK (1) DK136061C (en)
ES (1) ES412323A1 (en)
FI (1) FI55996C (en)
FR (1) FR2181789B1 (en)
GB (1) GB1379005A (en)
HU (1) HU167089B (en)
IE (1) IE37370B1 (en)
IL (1) IL41664A (en)
LU (1) LU67147A1 (en)
NL (1) NL7303137A (en)
PL (2) PL92078B1 (en)
RO (2) RO61192A (en)
SE (1) SE384208B (en)
ZA (1) ZA731501B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (en) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them
DE2406198C2 (en) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Process for the preparation of new 2-amino-6-dialkylamino-dihydropyridines
JPS5922593U (en) * 1982-08-03 1984-02-10 日本マランツ株式会社 Horn mounting structure for headphone
JPS5922594U (en) * 1982-08-03 1984-02-10 日本マランツ株式会社 earplug type headphone
JPS6282898A (en) * 1985-10-08 1987-04-16 Matsushita Electric Ind Co Ltd headphone
JPS6293060U (en) * 1985-11-28 1987-06-13
US20230416203A1 (en) * 2020-11-30 2023-12-28 Nanyang Technological University Potent and selective inhibitors of the calcium-activated potassium channel, kca3.1, for use as platform therapeutics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (en) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them
US3855231A (en) * 1972-03-06 1974-12-17 Bayer Ag 2,6-diamino-1,4-dihydropyridine derivatives
DE2406198C2 (en) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Process for the preparation of new 2-amino-6-dialkylamino-dihydropyridines

Also Published As

Publication number Publication date
DE2210687A1 (en) 1973-09-20
CH580589A5 (en) 1976-10-15
LU67147A1 (en) 1973-05-22
PL89256B1 (en) 1976-11-30
HU167089B (en) 1975-08-28
PL92078B1 (en) 1977-03-31
IE37370B1 (en) 1977-07-06
CA988524A (en) 1976-05-04
JPS48103579A (en) 1973-12-25
RO63068A (en) 1978-05-15
DE2210687B2 (en) 1980-09-04
IL41664A0 (en) 1973-05-31
DK136061B (en) 1977-08-08
FR2181789B1 (en) 1976-12-03
CS182781B2 (en) 1978-05-31
AT327904B (en) 1976-02-25
FR2181789A1 (en) 1973-12-07
KR780000119B1 (en) 1978-04-15
NL7303137A (en) 1973-09-10
ZA731501B (en) 1973-11-28
BG20583A3 (en) 1975-12-05
RO61192A (en) 1976-09-15
SE384208B (en) 1976-04-26
IE37370L (en) 1973-09-06
DE2210687C3 (en) 1981-09-24
JPS5911584B2 (en) 1984-03-16
CH577473A5 (en) 1976-07-15
AT324338B (en) 1975-08-25
CS182792B2 (en) 1978-05-31
JPS5626659B2 (en) 1981-06-19
ATA925774A (en) 1975-05-15
BE796279A (en) 1973-09-05
BG22815A3 (en) 1977-04-20
DD106833A5 (en) 1974-07-05
FI55996B (en) 1979-07-31
IL41664A (en) 1976-01-30
ES412323A1 (en) 1976-01-01
FI55996C (en) 1979-11-12
DK136061C (en) 1978-01-02
JPS5699460A (en) 1981-08-10

Similar Documents

Publication Publication Date Title
GB1384031A (en) N-substituted dihydropyridine compounds their production and their medicinal use
ES413809A1 (en) 1,4-Dihydropyridine carboxylic acid esters
GB1358951A (en) Esters their production and their medicinal use
FI900307A0 (en) Process for the preparation of therapeutically active 3- [3-oxo- (2,3) -dihydropyridazin-6-yl] -2-phenylpyrazolo [1,5-a] pyridine derivatives
GB1477114A (en) 1,4-dihydropyridinecarboxylic acid aralkyl esters processes for their preparation and their use as medicaments
GB1384504A (en) Bridgeheadheterocyclic compounds their production and their medicinal use
IE36947L (en) 14 - dihydropyridinecarboxycic acid esters
GB1389509A (en) Dihydropyridinepolyesters their production and their medicinal use
GB1369401A (en) Process for the manufacture of 2-amino-1,4-dihydropyridines and their use as coronary agents
GB1379005A (en) 2,6-diaminodihydropyridines their production and their medicinal use
ATE92036T1 (en) CARDIOVASCULAR ACTIVE CONNECTIONS.
GB1389504A (en) 2-amino-1,4-dihydropyridines their production and their medicinal use
GB1530413A (en) 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines
KR880009021A (en) Pyrazolo [3,4-d] pyrimidine derivatives, compositions and uses thereof
ES357029A1 (en) 3-substituted benzodiazepine derivatives and their preparation
IE38141B1 (en) New 3,4-dihydropyridones their production and their medicinal use
ES373909A1 (en) PROCEDURE FOR THE PREPARATION OF QUINAZOLINES.
IE37367L (en) 2-amino-4, 5-dihydropyridine-3, 5-dicarboxylic acid esters
IE38064L (en) 2-amino-4h-pyran derivatives.
GB1368546A (en) Partially hydrogenated benzoquinolizines their manufacture and their medicinal use
GB1173304A (en) A Process for the Manufacture of Benzoxadiaz[4,1,5]Ocines
GB1271147A (en) Novel 2,3-disubstituted quinazolinone derivatives
GB1392028A (en) 5-arylpyrido-b-6,7-1,4-diazepines
ES8301468A1 (en) 4,4-Disubstituted 1,4-dihydropyridines, process for their preparation and their use in medicaments.
IT1216103B (en) PEPTIDES WITH PHARMACEUTICAL ACTIVITY.

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee