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GB1371969A - Triazene derivatives their production and their medicinal use - Google Patents

Triazene derivatives their production and their medicinal use

Info

Publication number
GB1371969A
GB1371969A GB43991/72*2A GB4399172A GB1371969A GB 1371969 A GB1371969 A GB 1371969A GB 4399172 A GB4399172 A GB 4399172A GB 1371969 A GB1371969 A GB 1371969A
Authority
GB
United Kingdom
Prior art keywords
alkyl
halogen
compounds
production
sept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43991/72*2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1371969A publication Critical patent/GB1371969A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/22—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
    • C07C245/24—Chains of only three nitrogen atoms, e.g. diazoamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/61—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/49—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/52—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B43/00—Preparation of azo dyes from other azo compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1371969 Triazenes BAYER AG 22 Sept 1972 [24 Sept 1971 7 March 1972] 43991/72 Heading C2 The invention comprises compounds of formula wherein R is H or a cation, R<SP>1</SP>, R<SP>2</SP> are each H, C 1-4 alkyl, CO 4 H, SO 3 H or halogen; R<SP>3</SP>, R<SP>4</SP> are each H, CN, C 1-4 alkyl or alkoxy, CO 2 H, SO 3 H, halogen, SO 2 NH 2 or SO 2 N (C 1-4 alkyl) 2 ; X is a direct bond, N=N, O, CO, S(=O) 0-2 CH 2 or CH 2 CH 2 (either of which may be halogen-, OH- or C 1-4 alkyl-substituted), or CH=CH (optionally halogen- or C 1-4 alkyl-substituted); R<SP>5</SP>, R<SP>6</SP> are Me and/or Et; and the salts of such compounds which contain a CO 2 H or SO 3 H group. These compounds are prepared by reacting with HNR<SP>5</SP>R<SP>6</SP>, the corresponding amine (after diazotization); the latter is generally made by reducing the corresponding nitro-compound. Therapeutic compositions for oral, parenteral, rectal, topical or aerosol administration, comprise compounds of the above formula, which have concerostatic activity.
GB43991/72*2A 1971-09-24 1972-09-22 Triazene derivatives their production and their medicinal use Expired GB1371969A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2147781A DE2147781A1 (en) 1971-09-24 1971-09-24 TRIAZENE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
GB1371969A true GB1371969A (en) 1974-10-30

Family

ID=5820498

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43991/72*2A Expired GB1371969A (en) 1971-09-24 1972-09-22 Triazene derivatives their production and their medicinal use

Country Status (12)

Country Link
JP (2) JPS4839453A (en)
AT (1) AT317177B (en)
AU (1) AU456553B2 (en)
BE (1) BE789138A (en)
DD (1) DD103891A5 (en)
DE (1) DE2147781A1 (en)
FR (1) FR2154568B1 (en)
GB (1) GB1371969A (en)
HU (1) HU165298B (en)
IL (1) IL40406A0 (en)
NL (1) NL7212793A (en)
ZA (1) ZA726484B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122969A1 (en) 2011-03-16 2012-09-20 Creative Therapeutics Gmbh Substituted diphenyl derivatives
WO2012130850A1 (en) 2011-03-31 2012-10-04 Bayer Pharma Aktiengesellschaft Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors
EP2557075A1 (en) * 2011-08-09 2013-02-13 Trin Therapeutics GmbH New triazene compounds for treating cancer

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010104A1 (en) * 1980-03-15 1981-10-01 Basf Ag, 6700 Ludwigshafen AMINOAZO CONNECTIONS
US5189266A (en) * 1989-06-09 1993-02-23 Nissan Motor Co., Ltd. Vehicular exhaust resonance suppression system and sensing means therefore
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
MY122278A (en) 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
KR20100031620A (en) * 2007-07-04 2010-03-23 트린 파마 게엠베하 Novel triazene compounds for the treatment of cancer

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122969A1 (en) 2011-03-16 2012-09-20 Creative Therapeutics Gmbh Substituted diphenyl derivatives
CN103492365A (en) * 2011-03-16 2014-01-01 创新治疗有限公司 Substituted diphenyl derivatives
US9409859B2 (en) * 2011-03-16 2016-08-09 Creative Therapeutics Gmbh Substituted diphenyl derivatives
AU2012228755B2 (en) * 2011-03-16 2017-03-23 Creative Therapeutics Gmbh Substituted diphenyl derivatives
WO2012130850A1 (en) 2011-03-31 2012-10-04 Bayer Pharma Aktiengesellschaft Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors
EP2557075A1 (en) * 2011-08-09 2013-02-13 Trin Therapeutics GmbH New triazene compounds for treating cancer

Also Published As

Publication number Publication date
JPS4839453A (en) 1973-06-09
AU4695772A (en) 1974-03-28
AU456553B2 (en) 1974-12-02
NL7212793A (en) 1973-03-27
HU165298B (en) 1974-08-28
AT317177B (en) 1974-08-12
JPS4839614A (en) 1973-06-11
FR2154568B1 (en) 1976-03-05
FR2154568A1 (en) 1973-05-11
BE789138A (en) 1973-03-22
DD103891A5 (en) 1974-02-12
IL40406A0 (en) 1972-11-28
DE2147781A1 (en) 1973-03-29
ZA726484B (en) 1973-06-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees