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GB1371650A - Analgesic derivatives of the series of sulphur-containing arylamines - Google Patents

Analgesic derivatives of the series of sulphur-containing arylamines

Info

Publication number
GB1371650A
GB1371650A GB4424171A GB4424171A GB1371650A GB 1371650 A GB1371650 A GB 1371650A GB 4424171 A GB4424171 A GB 4424171A GB 4424171 A GB4424171 A GB 4424171A GB 1371650 A GB1371650 A GB 1371650A
Authority
GB
United Kingdom
Prior art keywords
aryl
group
sulphur
compounds
sept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4424171A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE788805D priority Critical patent/BE788805A/en
Application filed by Individual filed Critical Individual
Priority to GB4424171A priority patent/GB1371650A/en
Priority to FR7233005A priority patent/FR2154528B1/fr
Priority to CA152,193A priority patent/CA996129A/en
Priority to IL40393A priority patent/IL40393A0/en
Priority to CH1382272A priority patent/CH566308A5/xx
Priority to CH111274A priority patent/CH565757A5/xx
Priority to DE2246429A priority patent/DE2246429C3/en
Priority to NL7212829A priority patent/NL7212829A/xx
Priority to JP47094643A priority patent/JPS5755718B2/ja
Priority to ES406929A priority patent/ES406929A1/en
Priority to AR244227A priority patent/AR202378A1/en
Priority to AU46984/72A priority patent/AU472048B2/en
Priority to IN1482/72A priority patent/IN137842B/en
Priority to AR248332A priority patent/AR198415A1/en
Publication of GB1371650A publication Critical patent/GB1371650A/en
Priority to ES436363A priority patent/ES436363A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1371650 Aryl sulphoxides and sulphones V LAFON 21 Sept 1972 [22 Sept 1971] 44241/71 Heading C2C Novel compounds (I) (including salts thereof) of general formula ArSO x -A-NR 1 R 2 wherein x represents 1 or 2; A represents a C 2 -C 4 alkylene group; NR 1 R 2 represents a secondary or tertiary amino group or an N-heterocyclic amino group having 5 to 7 ring atoms which may include a second hetero atom which is sulphur, oxygen or nitrogen and which may carry one or more substituents selected from C 1 -C 5 alkyl, C 1 -C 5 hydroxyalkyl groups and phenyl, and when x is 1, Ar represents an aryl or halogeno-aryl group or, when x is 1 or 2, a 2-benzimidazolyl group, are made by standard methods, especially from the corresponding thioethers and compounds of formula The invention also comprises a process for making (I) where, when x is 1, Ar is aryl or haloaryl and when x is 1 or 2, Ar is 2-benzimidazolyl by reacting ArSO n A-Cl with HNR 1 R 2 (n is 0, 1 or 2) and, if necessary, oxidizing the compounds obtained. Pharmaceutical compositions having analgesic action contain (I) as active ingredient; administration may be orally or parenterally.
GB4424171A 1971-09-22 1971-09-22 Analgesic derivatives of the series of sulphur-containing arylamines Expired GB1371650A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
BE788805D BE788805A (en) 1971-09-22 NEW ANTALGIC DERIVATIVES FROM THE SULFUR ARYLAMINE SERIES
GB4424171A GB1371650A (en) 1971-09-22 1971-09-22 Analgesic derivatives of the series of sulphur-containing arylamines
FR7233005A FR2154528B1 (en) 1971-09-22 1972-09-18
CA152,193A CA996129A (en) 1971-09-22 1972-09-20 Analgesic derivatives of the series of sulphur-containing arylamines
IL40393A IL40393A0 (en) 1971-09-22 1972-09-20 Sulphone and sulphoxide derivatives of arylamines,their preparation and pharmaceutical compositions containing them
DE2246429A DE2246429C3 (en) 1971-09-22 1972-09-21 2-phenylsulfinyl compounds and analgesics containing these compounds
CH111274A CH565757A5 (en) 1971-09-22 1972-09-21
CH1382272A CH566308A5 (en) 1971-09-22 1972-09-21
NL7212829A NL7212829A (en) 1971-09-22 1972-09-22
JP47094643A JPS5755718B2 (en) 1971-09-22 1972-09-22
ES406929A ES406929A1 (en) 1971-09-22 1972-09-22 Analgesic derivatives of the series of sulphur-containing arylamines
AR244227A AR202378A1 (en) 1971-09-22 1972-09-22 PROCEDURE FOR OBTAINING N- (2-FENYLSULFONIL) -ETHYLMORPHOLINE HYDROCHLORIDE
AU46984/72A AU472048B2 (en) 1971-09-22 1972-09-22 New analgesic derivatives ofthe series of sulphur-containing arylamines
IN1482/72A IN137842B (en) 1971-09-22 1972-09-22
AR248332A AR198415A1 (en) 1971-09-22 1973-05-31 PROCEDURE FOR OBTAINING AMINATED ARYLMERCAPTAN S-OXIDES COMPOUNDS
ES436363A ES436363A1 (en) 1971-09-22 1975-04-07 Analgesic derivatives of the series of sulphur-containing arylamines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4424171A GB1371650A (en) 1971-09-22 1971-09-22 Analgesic derivatives of the series of sulphur-containing arylamines

Publications (1)

Publication Number Publication Date
GB1371650A true GB1371650A (en) 1974-10-23

Family

ID=10432415

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4424171A Expired GB1371650A (en) 1971-09-22 1971-09-22 Analgesic derivatives of the series of sulphur-containing arylamines

Country Status (13)

Country Link
JP (1) JPS5755718B2 (en)
AR (2) AR202378A1 (en)
AU (1) AU472048B2 (en)
BE (1) BE788805A (en)
CA (1) CA996129A (en)
CH (2) CH566308A5 (en)
DE (1) DE2246429C3 (en)
ES (2) ES406929A1 (en)
FR (1) FR2154528B1 (en)
GB (1) GB1371650A (en)
IL (1) IL40393A0 (en)
IN (1) IN137842B (en)
NL (1) NL7212829A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134996A (en) * 1976-08-16 1979-01-16 The Dow Chemical Company Method for inhibiting adp-induced platelet aggregation using phenylthioalkylamines
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285859A1 (en) * 1974-09-30 1976-04-23 Lafon Labor PHENYLSULFINYL-AMIDINES AND DERIVATIVES
FR2432316A1 (en) * 1978-08-02 1980-02-29 Choay Sa NOVEL MEDICINAL PRODUCTS CONTAINING, AS ACTIVE SUBSTANCE, BENZENESULFONE-LIKE COMPOUNDS, NOVEL SUCH COMPOUNDS AND PROCESS FOR THEIR PREPARATION
JPS5739044Y2 (en) * 1978-08-21 1982-08-27
FR2447909A1 (en) * 1979-01-31 1980-08-29 Choay Sa Alkyl phenyl sulphone(s) - used as antilipaemic agents, act on the central nervous system, and affect mitosis
JPS5964720U (en) * 1982-10-22 1984-04-28 日本軽金属株式会社 liquid container
AR243167A1 (en) 1985-08-24 1993-07-30 Hoechst Ag Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors
JP2933739B2 (en) * 1990-04-09 1999-08-16 明治製菓株式会社 Thiazole or imidazole derivatives and anti-ulcer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70880A (en) *
FR2100668A1 (en) * 1971-05-19 1972-03-24 Sumitomo Chemical Co Pharmacol-active heterocyclic cpds
JPS4946312A (en) * 1972-09-05 1974-05-02

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134996A (en) * 1976-08-16 1979-01-16 The Dow Chemical Company Method for inhibiting adp-induced platelet aggregation using phenylthioalkylamines
US4141983A (en) * 1976-08-16 1979-02-27 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors

Also Published As

Publication number Publication date
ES406929A1 (en) 1976-02-01
FR2154528A1 (en) 1973-05-11
IL40393A0 (en) 1972-11-28
BE788805A (en) 1973-01-02
DE2246429A1 (en) 1973-03-29
AU4698472A (en) 1974-03-28
AR202378A1 (en) 1975-06-06
AR198415A1 (en) 1974-06-21
NL7212829A (en) 1973-03-26
DE2246429C3 (en) 1982-05-19
JPS4836147A (en) 1973-05-28
IN137842B (en) 1975-09-27
AU472048B2 (en) 1976-05-13
CH566308A5 (en) 1975-09-15
CA996129A (en) 1976-08-31
CH565757A5 (en) 1975-08-29
ES436363A1 (en) 1977-01-01
FR2154528B1 (en) 1975-10-17
JPS5755718B2 (en) 1982-11-25
DE2246429B2 (en) 1981-07-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLE Entries relating assignments, transmissions, licences in the register of patents
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee