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GB1366133A - Fused ring indole derivatives - Google Patents

Fused ring indole derivatives

Info

Publication number
GB1366133A
GB1366133A GB125071*[A GB125071A GB1366133A GB 1366133 A GB1366133 A GB 1366133A GB 125071 A GB125071 A GB 125071A GB 1366133 A GB1366133 A GB 1366133A
Authority
GB
United Kingdom
Prior art keywords
alkyl
aryl
ketones
prepared
possibly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB125071*[A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB125071*[A priority Critical patent/GB1366133A/en
Priority to CY926A priority patent/CY926A/en
Priority to ZA718536A priority patent/ZA718536B/en
Priority to CA130950A priority patent/CA924724A/en
Priority to AU37558/72A priority patent/AU464388B2/en
Priority to AT7772A priority patent/AT312595B/en
Priority to PH13164*A priority patent/PH10257A/en
Priority to DE19722200584 priority patent/DE2200584A1/en
Priority to IE14/72A priority patent/IE35956B1/en
Priority to ES398678A priority patent/ES398678A1/en
Priority to EG12/72A priority patent/EG10888A/en
Priority to DK11672A priority patent/DK150143C/en
Priority to FR7200619A priority patent/FR2121699B1/fr
Priority to FI45/72A priority patent/FI54120C/en
Priority to AR240009A priority patent/AR192734A1/en
Priority to BE777911A priority patent/BE777911A/en
Priority to JP725481A priority patent/JPS5531156B2/ja
Priority to SE7200278A priority patent/SE398645B/en
Priority to CH36472A priority patent/CH573938A5/xx
Priority to NLAANVRAGE7200415,A priority patent/NL174251C/en
Priority to KE2777A priority patent/KE2777A/en
Priority to IE156872A priority patent/IE37158B1/en
Priority to CA156,588A priority patent/CA1010448A/en
Priority to AU48992/72A priority patent/AU475629B2/en
Priority to CA157,326A priority patent/CA1012150A/en
Priority to PH14115A priority patent/PH9906A/en
Priority to DE19722257784 priority patent/DE2257784A1/en
Priority to SE1585672A priority patent/SE398643B/en
Priority to ES409296A priority patent/ES409296A1/en
Priority to AR24549472A priority patent/AR199650A1/en
Priority to CH1772572A priority patent/CH575931A5/xx
Priority to NL7216545A priority patent/NL7216545A/xx
Priority to CH125976A priority patent/CH576450A5/xx
Priority to CH125876A priority patent/CH575398A5/en
Priority to US00313232A priority patent/US3850957A/en
Priority to US361701A priority patent/US3891644A/en
Priority to AR24906573A priority patent/AR199405A1/en
Priority to AR24906473A priority patent/AR201197A1/en
Priority to DE19742417917 priority patent/DE2417917A1/en
Priority to US472759A priority patent/US3926994A/en
Priority to US05/490,812 priority patent/US3998842A/en
Priority to AR25535974A priority patent/AR200230A1/en
Priority to AR25535874A priority patent/AR200229A1/en
Publication of GB1366133A publication Critical patent/GB1366133A/en
Priority to US05/582,038 priority patent/US3996207A/en
Priority to US05/582,043 priority patent/US3965112A/en
Priority to HK528/77A priority patent/HK52877A/en
Priority to MY197848A priority patent/MY7800048A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

1366133 Fused-ring indolines JOHN WYETH & BRO Ltd 14 Dec 1971 [11 Jan 1971 2 Sept 1971 6 Dec 1971] 1250/71 40959/71 and 56467/71 Heading C2C The invention comprises compounds of formula and their acid addition or quaternary ammonium salts, wherein R is OH (or its C 1-6 alkyl, aryl- C 1-6 -alkyl or tetrahydropyracyl ether, or ester derivative); R<SP>1</SP> is aryl (mono- or bicyclic), C 1-6 alkyl (possibly aryl- or amino-substituted), or up to C 6 alkenyl or alkynyl; or RR<SP>1</SP> is O=, or (when n is 1) its alkylene or di-(C 1-6 alkyl) ketal; R<SP>2</SP>, R<SP>5</SP> are each H, OH, halogen, NH 2 (possibly mono- or di-C 1-6 -alkyl substituted), or C 1-6 alkyl, haloalkyl or alkoxy, or (when RR<SP>1</SP> is O = or a ketal thereof) NO 2 ; R<SP>3</SP>, R<SP>4</SP> are each H or C 1-6 alkyl, or R<SP>3</SP> is H and R<SP>4</SP> is OH; n is 0-2; and R<SP>6</SP> (present only when the optional bond represented by the broken line is absent) is H, acyl, C 1-6 alkyl (possibly substituted by aryl, or up to C 6 alkenyl or alkynyl. In Examples, (1) the compounds containing the optional bond are prepared thus: (a) the ethylene ketals (A) by reductive ring-closure of corresponding 1-cyanoalkylizatin-3-ethyleneketals; (b) the ketones (B) by either hydrolysing ketals (A), or ring-closing corresponding 2-halophenyl/heterocyclyl ketones (C); (c) the alcohols by reacting ketones (B) with R<SP>1</SP>Mg-halide or R<SP>1</SP>-Li; (d) halogenation, nitration or esterification; ... (2) the compounds not containing the optional bond are prepared by reducing those containing it, possibly in the form of a quaternary ammonium salt. Ketones (C) are prepared by oxidizing the corresponding alcohols. 1 - (2 - Cyanoethyl) - 5 - methoxyizatin, bromo-tert-butyl cyanide and isatin-3-ethyleneketal are also prepared. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula (other than those where RR<SP>1</SP> is O= or a ketal thereof), which have antidepressant, antiinflammatory, antihistaminic, cardiovascular, diuretic and/or hypoglycaemic activity.
GB125071*[A 1971-01-11 1971-01-11 Fused ring indole derivatives Expired GB1366133A (en)

Priority Applications (47)

Application Number Priority Date Filing Date Title
GB125071*[A GB1366133A (en) 1971-01-11 1971-01-11 Fused ring indole derivatives
CY926A CY926A (en) 1971-01-11 1971-12-14 Fused ring indole derivatives
ZA718536A ZA718536B (en) 1971-01-11 1971-12-21 Heterocyclic compounds
CA130950A CA924724A (en) 1971-01-11 1971-12-23 Heterocyclic compounds
AU37558/72A AU464388B2 (en) 1971-01-11 1972-01-04 Fused n-heteroindole derivatives
AT7772A AT312595B (en) 1971-01-11 1972-01-05 Process for the production of new indole derivatives and their salts
PH13164*A PH10257A (en) 1971-01-11 1972-01-07 2,3,4,10-tetrahydro and 1,2,3,4,10-hexahydropyrimido(1,2-a)indoles
DE19722200584 DE2200584A1 (en) 1971-01-11 1972-01-07 Imido-,pyrimido-,and diazepino-(1,2-a)indoles -antidepressants - antiinflammatories,antihistamines,and hypoglycaemics with cardiovascu
IE14/72A IE35956B1 (en) 1971-01-11 1972-01-08 Fused ring indole derivatives
ES398678A ES398678A1 (en) 1971-01-11 1972-01-08 Fused ring indole derivatives
EG12/72A EG10888A (en) 1971-01-11 1972-01-09 Process for preparation of heterocyclic compound from indofe derivatives
DK11672A DK150143C (en) 1971-01-11 1972-01-10 ANALOGY PROCEDURE FOR THE PREPARATION OF INCIDENTAL DERIVATIVES
FR7200619A FR2121699B1 (en) 1971-01-11 1972-01-10
FI45/72A FI54120C (en) 1971-01-11 1972-01-10 FRUIT PROTECTION FOR PHARMACEUTICAL FRAMEWORK ANVAIDBARA ANTIDEPRESSIVT VERKANDE TETRAHYDROPYRIMIDO (1,2-A) INDOL-TETRAHYDRO-1,3-DIAZEPINO (1-2-A) INDOL-OCH DIHYDROIMIDASO
AR240009A AR192734A1 (en) 1971-01-11 1972-01-10 A PROCEDURE FOR PREPARING AN INDOLE DERIVATIVE
BE777911A BE777911A (en) 1971-01-11 1972-01-11 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP725481A JPS5531156B2 (en) 1971-01-11 1972-01-11
SE7200278A SE398645B (en) 1971-01-11 1972-01-11 ANALOGICAL PROCEDURE FOR PREPARING CONDENSED INDOLE ASSOCIATIONS
CH36472A CH573938A5 (en) 1971-01-11 1972-01-11
NLAANVRAGE7200415,A NL174251C (en) 1971-01-11 1972-01-11 METHOD FOR PREPARING PHARMACEUTICAL PREPARATIONS BASED ON INDOOL DERIVATIVES, AND METHOD FOR PREPARING INDOOL DERIVATIVES
KE2777A KE2777A (en) 1971-01-11 1972-10-26 Fused ring indole derivatives
IE156872A IE37158B1 (en) 1971-01-11 1972-11-15 Tetrahydropyrimidines imidazolines and tetrahydro-1,3- diazepines
CA156,588A CA1010448A (en) 1971-01-11 1972-11-16 Tetrahydropyrimidine, imidazoline and tetrahydro-1,3-diazepine derivatives
AU48992/72A AU475629B2 (en) 1971-01-11 1972-11-17 Tetrahydo-pyrimidines, imidazolines and tetrahydro-1, 3-diazepines
CA157,326A CA1012150A (en) 1971-01-11 1972-11-23 Indole derivatives
PH14115A PH9906A (en) 1971-01-11 1972-11-24 Tetrahydropyrimidines,imidazolines and tetrahydro-1,3-diazepines
DE19722257784 DE2257784A1 (en) 1971-01-11 1972-11-24 Derivs of tetrahydrpyrimidines,imidazolin and tetrahydro - -1,3-diazepin - with diuretic anti-inflammatory,cardiovascular,hypogl
SE1585672A SE398643B (en) 1971-01-11 1972-12-05 PROCEDURE FOR MAKING DERIVATIVES OF IMIDAZOLINE, TETRA HYDRO-PYRIMIDINE AND TETRA HYDRO-1,3-DIAZEPINE
ES409296A ES409296A1 (en) 1971-01-11 1972-12-05 Fused ring indole derivatives
AR24549472A AR199650A1 (en) 1971-01-11 1972-12-05 PROCEDURE FOR PREPARING TETRAHYDROPYRIMIDINE DERIVATIVES
CH1772572A CH575931A5 (en) 1971-01-11 1972-12-06
NL7216545A NL7216545A (en) 1971-01-11 1972-12-06
CH125976A CH576450A5 (en) 1971-01-11 1972-12-06
CH125876A CH575398A5 (en) 1971-01-11 1972-12-06 Derivs of tetrahydrpyrimidines,imidazolin and tetrahydro - -1,3-diazepin - with diuretic anti-inflammatory,cardiovascular,hypogl
US00313232A US3850957A (en) 1971-01-11 1972-12-08 2,3-dihydroimidazo(1,2-a)indoles
US361701A US3891644A (en) 1971-01-11 1973-05-18 10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives
AR24906573A AR199405A1 (en) 1971-01-11 1973-07-12 PROCEDURE FOR PREPARING TETRAHYDROPYRIMIDINE DERIVATIVES
AR24906473A AR201197A1 (en) 1971-01-11 1973-07-12 PROCEDURE FOR PREPARING TETRAHYDROPYRIMIDINE DERIVATIVES
DE19742417917 DE2417917A1 (en) 1971-01-11 1974-04-11 PROCESS FOR MANUFACTURING INDOLDER DERIVATIVES WITH A CONDENSED RING SYSTEM
US472759A US3926994A (en) 1971-01-11 1974-05-23 Heterocyclic compounds
US05/490,812 US3998842A (en) 1971-01-11 1974-07-22 Diazepino[1,2-α]indoles
AR25535974A AR200230A1 (en) 1971-01-11 1974-08-28 PROCEDURE TO PREPARE A TETRAHYDRO-1,3-DIAZEPINE
AR25535874A AR200229A1 (en) 1971-01-11 1974-08-28 PROCEDURE TO PREPARE AN IMIDAZOLINE
US05/582,038 US3996207A (en) 1971-01-11 1975-05-29 Derivatives of tetrahydro-1H-1,3-diazepine and hexahydro-1,3-diazocine
US05/582,043 US3965112A (en) 1971-01-11 1975-05-29 Imidazoline derivatives
HK528/77A HK52877A (en) 1971-01-11 1977-10-13 Fused ring indole derivatives
MY197848A MY7800048A (en) 1971-01-11 1978-12-31 Fused ring indole derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB125071*[A GB1366133A (en) 1971-01-11 1971-01-11 Fused ring indole derivatives
GB4095971 1971-09-02
GB5646771 1971-12-06

Publications (1)

Publication Number Publication Date
GB1366133A true GB1366133A (en) 1974-09-11

Family

ID=27253859

Family Applications (1)

Application Number Title Priority Date Filing Date
GB125071*[A Expired GB1366133A (en) 1971-01-11 1971-01-11 Fused ring indole derivatives

Country Status (20)

Country Link
JP (1) JPS5531156B2 (en)
AR (1) AR192734A1 (en)
AT (1) AT312595B (en)
AU (1) AU464388B2 (en)
BE (1) BE777911A (en)
CA (1) CA1012150A (en)
CH (1) CH573938A5 (en)
CY (1) CY926A (en)
DK (1) DK150143C (en)
EG (1) EG10888A (en)
ES (2) ES398678A1 (en)
FI (1) FI54120C (en)
FR (1) FR2121699B1 (en)
GB (1) GB1366133A (en)
HK (1) HK52877A (en)
IE (1) IE35956B1 (en)
KE (1) KE2777A (en)
MY (1) MY7800048A (en)
NL (1) NL174251C (en)
SE (1) SE398645B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073906A (en) 1974-11-20 1978-02-14 John Wyeth & Brother Limited Pyrimido 1,2-b!isoquinolines
US4126683A (en) * 1976-06-11 1978-11-21 John Wyeth & Brother Limited Fused ring indole derivatives and antidepressant compositions containing them
US4451465A (en) * 1981-07-07 1984-05-29 John Wyeth & Brother Ltd. Anti-obesity agents
EP0240176A1 (en) * 1986-03-13 1987-10-07 JOHN WYETH &amp; BROTHER LIMITED Substituted pyrimidoindoles
US4783455A (en) * 1986-06-11 1988-11-08 John Wyeth And Brother Ltd. Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics
US4784996A (en) * 1986-03-13 1988-11-15 John Wyeth & Brother Ltd. Pyrimidoindoles useful as hypoglycaemics
WO2010090680A1 (en) * 2008-12-15 2010-08-12 Wyeth Llc Substituted oxindole cb2 agonists

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5845741B2 (en) * 1977-06-06 1983-10-12 株式会社日立製作所 information retrieval device
JPS60204057A (en) * 1984-03-28 1985-10-15 Casio Comput Co Ltd Small electronic device with data storage function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888846A (en) * 1967-03-30 1975-06-10 Hoffmann La Roche Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives
US3586693A (en) * 1969-07-07 1971-06-22 American Home Prod Imidazo(1,2-a)indolin-9-ols

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073906A (en) 1974-11-20 1978-02-14 John Wyeth & Brother Limited Pyrimido 1,2-b!isoquinolines
US4126683A (en) * 1976-06-11 1978-11-21 John Wyeth & Brother Limited Fused ring indole derivatives and antidepressant compositions containing them
US4451465A (en) * 1981-07-07 1984-05-29 John Wyeth & Brother Ltd. Anti-obesity agents
EP0240176A1 (en) * 1986-03-13 1987-10-07 JOHN WYETH &amp; BROTHER LIMITED Substituted pyrimidoindoles
US4784996A (en) * 1986-03-13 1988-11-15 John Wyeth & Brother Ltd. Pyrimidoindoles useful as hypoglycaemics
US4803207A (en) * 1986-03-13 1989-02-07 John Wyeth & Brother Ltd. Hypoglycemic 2',3',10'-tetrahydro-10'-hydroxy-10'-substituted-spiro[cycloakane-1,3'-pyrimido(1,2-a)indole]deratives
US4783455A (en) * 1986-06-11 1988-11-08 John Wyeth And Brother Ltd. Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics
WO2010090680A1 (en) * 2008-12-15 2010-08-12 Wyeth Llc Substituted oxindole cb2 agonists

Also Published As

Publication number Publication date
AU464388B2 (en) 1975-08-28
ES409296A1 (en) 1976-03-16
DK150143B (en) 1986-12-15
IE35956B1 (en) 1976-07-07
IE35956L (en) 1972-07-11
MY7800048A (en) 1978-12-31
NL174251C (en) 1984-05-16
BE777911A (en) 1972-07-11
KE2777A (en) 1977-10-21
AT312595B (en) 1974-01-10
CH573938A5 (en) 1976-03-31
AU3755872A (en) 1973-07-05
FI54120C (en) 1978-10-10
CA1012150A (en) 1977-06-14
ES398678A1 (en) 1975-05-16
JPS5531156B2 (en) 1980-08-15
FI54120B (en) 1978-06-30
AR192734A1 (en) 1973-03-14
NL174251B (en) 1983-12-16
CY926A (en) 1977-12-23
FR2121699B1 (en) 1975-08-01
DK150143C (en) 1987-06-01
NL7200415A (en) 1972-07-13
JPS4839500A (en) 1973-06-09
HK52877A (en) 1977-10-20
SE398645B (en) 1978-01-09
FR2121699A1 (en) 1972-08-25
EG10888A (en) 1978-06-30

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