GB1366127A - Hypocalcaemic peptides - Google Patents
Hypocalcaemic peptidesInfo
- Publication number
- GB1366127A GB1366127A GB4988071A GB4988071A GB1366127A GB 1366127 A GB1366127 A GB 1366127A GB 4988071 A GB4988071 A GB 4988071A GB 4988071 A GB4988071 A GB 4988071A GB 1366127 A GB1366127 A GB 1366127A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thr
- gly
- gln
- pronh
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 230000001184 hypocalcaemic effect Effects 0.000 title 1
- 108010061238 threonyl-glycine Proteins 0.000 abstract 5
- 108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 abstract 3
- 108010079364 N-glycylalanine Proteins 0.000 abstract 2
- VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229940121799 Hypocalcaemic agent Drugs 0.000 abstract 1
- FJJWGZOCZQHVEO-RQJHMYQMSA-N O-t-butyl-l-threonine methyl ester Chemical compound COC(=O)[C@@H](N)[C@@H](C)OC(C)(C)C FJJWGZOCZQHVEO-RQJHMYQMSA-N 0.000 abstract 1
- 108010047495 alanylglycine Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 108010015792 glycyllysine Proteins 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1366127 Dotricontapeptides SANDOZ Ltd 27 Oct 1971 [29 Oct 1970 17 Dec 1970 5 July 1971 (2)] 49880/71 Heading C2C Compounds (I), their salts and metal complexes, H - Cys - Ser - Asn - Leu - Ser - Thr - Cys- Val - Leu - Gly - Lys - Leu - Ser - Gln - Asp - Leu- His - Lys - Leu - Gln - Thr - Phe - Pro - Arg - Thr- Asn - Thr - Gly - X - Gly - Y - ProNH 2 (I) (where X is Val and Y is Ala or X is Ala and Y is Val) are prepared by known methods for preparing peptides especially a blocked nonapeptide (1-9 ,I) condensed with a tricosapeptide (10-23, I) and blocking groups removed. The following starting materials and intermediates are prepared: HVal-Gly-Ala-ProNH 2 , Z- and H-Val-ProNH 2 , Z- and H-Gly-Val-Pro- NH 2 , Z- and H-Ala-Gly-Val-ProNH 2 , Z-Thr- Asn - Thr - GlyNHNH 2 , BOC and H - Arg- Thr - Asn - Thr - Gly - Val - Gly - Ala - ProNH 2 , HArg - Thr - Asn - Thr - Gly - Ala - Gly - Val- ProNH 2 , Z - Thr - Asn - Thr - Gly - Val - Gly- Ala - ProNH 2 , Z - Thr - Asn - Thr - Gly - Ala- Gly - Val - ProNH 2 , H - Thr - Asn - Thr - Gly- Val - Gly - Ala - ProNH 2 , Z 3 - Arg - Thr - Asn- Thr - Gly - Val - Gly - Ala - ProNH 2 , Z 3 - Arg- Thr - Asn - Thr - Gly - Ala - Gly - Val - ProNH 2 , H - Phe - ProOMe, Z - Thr - Phe - ProOMe and -OH, HThr - Phe - ProOH, Z - His - Lys(BOC)- Leu - Gln - Thr - Phe - Pro - OH, H - Thr(tBu)- OMe, Z - Gln - Thr(tBu)OMe and - NHNH 2 , H - Phe - ProOMe, HCl, Z - Gln - Thr(tBu)- Phe - ProOMe, Z - Gln - Thr - Phe - ProOMe, Z - and H - Lys(BOC) - LeuOMe, Z - His - Lys- (BOC)LeuOMe and NHNH 2 , H - Gln - Thr- Phe - ProNH 2 , Z - His - Lys(BOC) - Leu - Gln- Thr - Phe - ProOMe and - NHNH 2 , Z - His- Lys - (BOC) - Leu - Gln - Thr - Phe - ProOSu, H - and Z - His - Lys(BOC) - Leu - Gln - Thr- Phe - Pro - Arg - Thr - Asn - Thr - Gly - X - Gly- Y - ProNH 2 , H - and Z - Asp(OTB) - LeuOMe. Z - and H - Gln - Asp(OTB) - Leu - OMe, ZSer - Gln - Asp(OTB) - LeuOMe, Trt - Gly - Lys- (BOC) - LeuOMe and - NHNH 2 , Trt - Gly - Lys- (BOC) - Leu - Ser - Gln - Asp(OTB)LeuOMe and -NHNH 2 , Trt - and H - Gly - Lys(BOC) - Leu- Ser - Gln - Asp(OTB) - Leu - His - Lys(BOC)- Leu - Gln - Thr - Phe - Pro - Arg - Thr - Asn- Thr-Gly-X-Gly-Y-ProNH 2 and the corresponding terminal N-BOC-blocked derivatives of (I). Pharmaceutical compositions, useful as hypocalcaemic agents comprise (I) and a diluent in a form for parenteral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1351660D GB1351660A (en) | 1971-10-27 | 1971-10-27 | Flying spot film scanner |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1599270A CH541541A (en) | 1970-10-29 | 1970-10-29 | Parathormone-antagonistic polypeptides - with effe cts on calcium metabolism |
| CH1870670A CH551378A (en) | 1970-12-17 | 1970-12-17 | Parathormone-antagonistic polypeptides - with effe cts on calcium metabolism |
| CH982671 | 1971-07-05 | ||
| CH982771 | 1971-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1366127A true GB1366127A (en) | 1974-09-11 |
Family
ID=27429253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4988071A Expired GB1366127A (en) | 1970-10-29 | 1971-10-27 | Hypocalcaemic peptides |
Country Status (6)
| Country | Link |
|---|---|
| DD (1) | DD96064A5 (en) |
| DE (1) | DE2153780A1 (en) |
| FR (1) | FR2111909B1 (en) |
| GB (1) | GB1366127A (en) |
| NL (1) | NL7114845A (en) |
| SE (1) | SE375768B (en) |
-
1971
- 1971-10-27 FR FR7138646A patent/FR2111909B1/fr not_active Expired
- 1971-10-27 GB GB4988071A patent/GB1366127A/en not_active Expired
- 1971-10-28 DD DD15861471A patent/DD96064A5/xx unknown
- 1971-10-28 DE DE19712153780 patent/DE2153780A1/en active Pending
- 1971-10-28 NL NL7114845A patent/NL7114845A/xx unknown
- 1971-10-28 SE SE1372771A patent/SE375768B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD96064A5 (en) | 1973-03-05 |
| DE2153780A1 (en) | 1972-05-04 |
| FR2111909A1 (en) | 1972-06-09 |
| NL7114845A (en) | 1972-05-03 |
| FR2111909B1 (en) | 1975-04-18 |
| SE375768B (en) | 1975-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |