GB1364987A - Biologically active two component complexes - Google Patents
Biologically active two component complexesInfo
- Publication number
- GB1364987A GB1364987A GB2606072A GB2606072A GB1364987A GB 1364987 A GB1364987 A GB 1364987A GB 2606072 A GB2606072 A GB 2606072A GB 2606072 A GB2606072 A GB 2606072A GB 1364987 A GB1364987 A GB 1364987A
- Authority
- GB
- United Kingdom
- Prior art keywords
- component
- complexes
- acid
- homopolynucleotides
- polyribo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 3
- 150000003863 ammonium salts Chemical class 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 101001066878 Homo sapiens Polyribonucleotide nucleotidyltransferase 1, mitochondrial Proteins 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 102000002681 Polyribonucleotide nucleotidyltransferase Human genes 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1364987 Nucleotide complexes MERCK PATENT GmbH 5 June 1972 [19 June 1971 14 April 1972] 26060/72 Heading C2P [Also in Divisions A5 and C3] Two-component complexes, capable of inducing the formation of interferon in vertebrate animals, comprise (A) a mono- or poly-riboinosinic acid of Formula I: in which R<SP>1</SP> is wherein k is 1 to 3 and b is from 1 to 2000, or a metal or ammonium salt thereof, and (B) a mono- or polyribo-2-thiocytidylic acid of Formula III: in which R<SP>2</SP> is wherein m is 1 to 3 and n is from 1 to 2000, or a metal or ammonium salt thereof. The preferred complexes have k = m = 1, and b and/or n is greater than 100. The complexes may be prepared by admixing solutions of the homopolynucleotides of Formulae I and III. Alternatively, one of the homopolynucleotides may be formed in a solution of the other. Example 3 discloses a preparation of the two-component complex involving (essentially) the incubation at 37 C. for four hours of a mixture containing polynucleotide phosphorylase, disodium-2-thiocytidine-5<SP>1</SP>-diphosphate and component A. Example 4 discloses the preparation of the complex from polyribo-2,4-dithiouridylic acid and component A.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712130544 DE2130544A1 (en) | 1971-06-19 | 1971-06-19 | Polyribo-inosinic and 2-thiocytidylic acid complexes - as anti (virals, bacterials, protozoals) inducing interferon formation, also |
| DE19722218057 DE2218057A1 (en) | 1972-04-14 | 1972-04-14 | Loom - having two-component resilient stop for arresting - picker after picking |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1364987A true GB1364987A (en) | 1974-08-29 |
Family
ID=25761303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2606072A Expired GB1364987A (en) | 1971-06-19 | 1972-06-05 | Biologically active two component complexes |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3843629A (en) |
| AU (1) | AU467984B2 (en) |
| BE (1) | BE785012A (en) |
| CA (1) | CA988082A (en) |
| CH (1) | CH584719A5 (en) |
| DD (1) | DD100718A5 (en) |
| ES (1) | ES404001A1 (en) |
| FR (1) | FR2143060B1 (en) |
| GB (1) | GB1364987A (en) |
| IL (1) | IL39649A (en) |
| NL (1) | NL7207984A (en) |
| SE (2) | SE385587B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2185026B (en) * | 1986-01-06 | 1990-08-08 | Nippon Shinyaku Co Ltd | Thiolated nucleic acid derivatives. |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024222A (en) * | 1973-10-30 | 1977-05-17 | The Johns Hopkins University | Nucleic acid complexes |
| US3952097A (en) * | 1974-09-27 | 1976-04-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US5126439A (en) * | 1987-09-22 | 1992-06-30 | Temple University | Artificial dna base pair analogues |
| US4882147A (en) * | 1987-12-16 | 1989-11-21 | The Research Foundation Of State University Of New York | Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon |
| ATE535231T1 (en) * | 2002-07-03 | 2011-12-15 | Oncovir Inc | METHOD FOR PRODUCING POLY-ICLC AND USE THEREOF |
-
1972
- 1972-06-05 GB GB2606072A patent/GB1364987A/en not_active Expired
- 1972-06-08 IL IL39649A patent/IL39649A/en unknown
- 1972-06-12 DD DD163626A patent/DD100718A5/xx unknown
- 1972-06-12 NL NL7207984A patent/NL7207984A/xx not_active Application Discontinuation
- 1972-06-15 SE SE7207893A patent/SE385587B/en unknown
- 1972-06-15 AU AU43472/72A patent/AU467984B2/en not_active Expired
- 1972-06-16 CA CA144,918A patent/CA988082A/en not_active Expired
- 1972-06-16 CH CH905772A patent/CH584719A5/xx not_active IP Right Cessation
- 1972-06-16 US US00263677A patent/US3843629A/en not_active Expired - Lifetime
- 1972-06-16 BE BE785012A patent/BE785012A/en unknown
- 1972-06-17 ES ES404001A patent/ES404001A1/en not_active Expired
- 1972-06-19 FR FR7221993A patent/FR2143060B1/fr not_active Expired
-
1974
- 1974-12-18 SE SE7415908A patent/SE7415908L/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2185026B (en) * | 1986-01-06 | 1990-08-08 | Nippon Shinyaku Co Ltd | Thiolated nucleic acid derivatives. |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7415908L (en) | 1974-12-18 |
| AU467984B2 (en) | 1973-12-20 |
| IL39649A0 (en) | 1972-08-30 |
| NL7207984A (en) | 1972-12-21 |
| FR2143060B1 (en) | 1975-06-20 |
| CH584719A5 (en) | 1977-02-15 |
| CA988082A (en) | 1976-04-27 |
| US3843629A (en) | 1974-10-22 |
| ES404001A1 (en) | 1975-11-16 |
| AU4347272A (en) | 1973-12-20 |
| FR2143060A1 (en) | 1973-02-02 |
| DD100718A5 (en) | 1973-10-05 |
| SE385587B (en) | 1976-07-12 |
| BE785012A (en) | 1972-12-18 |
| IL39649A (en) | 1975-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |