GB1364497A - Therapeutically useful polypeptides - Google Patents
Therapeutically useful polypeptidesInfo
- Publication number
- GB1364497A GB1364497A GB5823571A GB5823571A GB1364497A GB 1364497 A GB1364497 A GB 1364497A GB 5823571 A GB5823571 A GB 5823571A GB 5823571 A GB5823571 A GB 5823571A GB 1364497 A GB1364497 A GB 1364497A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pro
- lys
- thr
- arg
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 108010071097 threonyl-lysyl-proline Proteins 0.000 abstract 5
- 108010004914 prolylarginine Proteins 0.000 abstract 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
- IESDGNYHXIOKRW-YXMSTPNBSA-N (2s)-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s,3r)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-YXMSTPNBSA-N 0.000 abstract 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 abstract 1
- 108010053993 N-terminal tetrapeptide cystatin C Proteins 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- GVUVRRPYYDHHGK-VQVTYTSYSA-N Pro-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 GVUVRRPYYDHHGK-VQVTYTSYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 108010068380 arginylarginine Proteins 0.000 abstract 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 108010074605 gamma-Globulins Proteins 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008884 pinocytosis Effects 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1364497 Polypeptides RESEARCH CORP 15 Dec 1971 [16 Dec 1970] 58235/71 Headings C2C and C2A Polypeptides including at least four and up to nineteen amino acids comprising one unit or repeating units; each unit containing four or five amino acids, at least one terminal amino acid of which is hydroxyl substituted; each unit including two basic amino acids linked together by one or two proline molecules; and each repeating unit being joined to an adjacent repeating unit by proline or cystine; and their pharmacologically acceptable salts and derivatives are claimed per se. They are prepared by conventional methods of peptide synthesis including solid phase synthesis on a polystyrenedivinyl-benzene-chloromethylated resin or may be isolated from gamma globulin. Peptides isolated or specifically mentioned are: H - thr - lys - pro - arg - OH; H - ser - lys - proarg - OH; H - thr - lys - pro - lys - OH; H - thrarg - pro - arg - OH; H - thr - arg - pro - lys- OH; H - thr - arg - pro - orn - OH; H - thr - lyspro - orn - OH; H - thr - lys - pro - his - OH ; H - ser - lys - pro - his - OH; H - arg - pro - lys ser - OH; H - lys - pro - lys - thr - OH; H - argpro - arg - thr - OH; H - lys - pro - arg - thr- OH; H - orn - pro - arg - thr - OH; H - orn - prolys - thr - OH; H - his - pro - lys - thr - OH; H - his - pro - lys - ser - OH; H - thr - lys - propro - arg - OH; H - thr - thr - lys - pro - arg- OH; H - thr - lys - lys - pro - arg - OH; H - thrlys - pro - arg - arg - OH; H-ser-lys-pro-pro-arg- OH; H - thr - lys - pro - arg - (pro - thr - lyspro - arg)3 - OH; and (H - arg - pro - lys - thraps-2. The amino acid units may be in the D- or L- forms. Also described are the novel polypeptides which are acylated at the free OH of threonine by an alkanoyl or alkenoyl group of up to 18C (e.g. acetyl, propionyl, butyryl and stearoyl). H - (O - penicillinyl) - thr - lys - pro - arg - OH and N<SP>α</SP> - penicillinyl thr - lys - pro - arg - OH are also described. Pharmaceutical compositions comprise the novel peptides together with non-toxic carriers and may be administered orally or parenterally as phagocytosis or pinocytosis stimulants or inhibitors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9889070A | 1970-12-16 | 1970-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1364497A true GB1364497A (en) | 1974-08-21 |
Family
ID=22271422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5823571A Expired GB1364497A (en) | 1970-12-16 | 1971-12-15 | Therapeutically useful polypeptides |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3778426A (en) |
| JP (1) | JPS6053040B1 (en) |
| CA (1) | CA999851A (en) |
| CH (1) | CH605672A5 (en) |
| DE (1) | DE2124003C2 (en) |
| FR (1) | FR2118134B1 (en) |
| GB (1) | GB1364497A (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966701A (en) * | 1973-11-07 | 1976-06-29 | The Dow Chemical Company | Fibrinogen peptide derivatives |
| US4073890A (en) * | 1974-03-26 | 1978-02-14 | Takeda Chemical Industries, Ltd. | Novel polypeptides |
| US4001199A (en) * | 1974-03-26 | 1977-01-04 | Takeda Chemical Industries, Ltd. | Novel polypeptides useful for treating diabetes and hypercholesteremia |
| US4016259A (en) * | 1974-07-26 | 1977-04-05 | Research Corporation | Contraceptive polypeptides |
| SE407058B (en) * | 1974-12-05 | 1979-03-12 | Kabi Ab | NEW CHROMOGENA ENZYME SUBSTRATE FOR SERINE PROTEASES |
| DE2602443A1 (en) * | 1975-04-04 | 1976-10-21 | Univ California | BIOLOGICALLY ACTIVE POLYPEPTIDES |
| US4061625A (en) * | 1975-07-11 | 1977-12-06 | Ab Kabi | Novel chromogenic thrombin substrates |
| US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
| US4181717A (en) * | 1978-09-07 | 1980-01-01 | Research Corporation | Ovulation enhancing peptides |
| IT8021120A0 (en) * | 1979-04-02 | 1980-04-01 | Inst Organicheskogo Sinteza Ak | CYCLIC ANALOGUE OF THE NATURAL PEPTIDE THAT STIMULATES PHAGOCYTOSIS: THREONYL-CYCLE (N-LYSYL-PROLYL-ARGINYL). |
| US4683292A (en) * | 1983-08-12 | 1987-07-28 | Immunetech, Inc. | Immunotherapeutic polypeptide agents which bind to lymphocyte immunoglobulin FC receptors |
| US4752601A (en) * | 1983-08-12 | 1988-06-21 | Immunetech Pharmaceuticals | Method of blocking immune complex binding to immunoglobulin FC receptors |
| US4585757A (en) * | 1984-07-27 | 1986-04-29 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| IT1188646B (en) * | 1986-04-09 | 1988-01-20 | Ellem Ind Farmaceutica | TRIPEPTIDE WITH IMMUNOSTIMULANT ACTIVITY |
| GB8807427D0 (en) * | 1988-03-28 | 1988-05-05 | National Biological Standards Board | Peptides |
| EP0335662B1 (en) | 1988-03-28 | 1995-07-26 | Btg International Limited | Peptides |
| IT1230712B (en) * | 1989-02-10 | 1991-10-29 | Sclavo Spa | COMPOSITION FOR VACCINES |
| US5028593A (en) * | 1989-08-15 | 1991-07-02 | Board Of Regents, The University Of Texas System | Tuftsin analogs |
| IT1232311B (en) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | PURIFICATION METHOD OF LOW MOLECULAR PEPTIDIC OR PSEUDO PEPTIDIC STRUCTURE COMPOUNDS. |
| GB9211668D0 (en) * | 1992-06-02 | 1992-07-15 | Nycomed Bioreg As | Peptide compounds |
| IL134830A0 (en) * | 2000-03-01 | 2001-05-20 | Chay 13 Medical Res Group N V | Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them |
| US7666996B2 (en) * | 2000-03-01 | 2010-02-23 | Peptera Pharmaceuticals Ltd | Casein derived peptides and uses thereof |
| PL375113A1 (en) * | 2001-08-30 | 2005-11-28 | Chay 13 Medical Research Group N.V. | Casein derived peptides and uses thereof in therapy |
| KR20100057054A (en) * | 2007-09-11 | 2010-05-28 | 몬도바이오테크 래보래토리즈 아게 | Use of a tuftsin as a therapeutic agent |
| RU2507212C3 (en) * | 2012-03-28 | 2022-05-04 | Общество С Ограниченной Ответственностью "Айвикс" | METHOD FOR PRODUCING RECOMBINANT PEPTIDE AND PRODUCED PEPTIDE |
| CN104662034B (en) * | 2013-05-28 | 2021-05-11 | "Ivix"有限公司 | Method for producing recombinant peptides and peptides obtained |
| RU2626002C1 (en) | 2016-10-24 | 2017-07-21 | Общество С Ограниченной Ответственностью "Айвикс" | New group of peptides for treatment of female sexual dysfunction |
| JP2018118973A (en) * | 2018-02-23 | 2018-08-02 | アイビックス・リミテッドＩｖｉｘ Ｌｔｄ． | Method for producing recombinant peptides and resulting peptides |
-
1970
- 1970-12-16 US US00098890A patent/US3778426A/en not_active Expired - Lifetime
-
1971
- 1971-05-14 DE DE2124003A patent/DE2124003C2/en not_active Expired
- 1971-05-14 JP JP46032004A patent/JPS6053040B1/ja active Granted
- 1971-12-10 CA CA129,894A patent/CA999851A/en not_active Expired
- 1971-12-15 GB GB5823571A patent/GB1364497A/en not_active Expired
- 1971-12-16 FR FR7145283A patent/FR2118134B1/fr not_active Expired
- 1971-12-16 CH CH1838971A patent/CH605672A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6053040B1 (en) | 1985-11-22 |
| FR2118134A1 (en) | 1972-07-28 |
| CH605672A5 (en) | 1978-10-13 |
| FR2118134B1 (en) | 1975-10-10 |
| DE2124003C2 (en) | 1982-04-22 |
| DE2124003A1 (en) | 1972-06-22 |
| US3778426A (en) | 1973-12-11 |
| CA999851A (en) | 1976-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |