GB1363033A - Derivatives of 22-fluoro-digoxins - Google Patents
Derivatives of 22-fluoro-digoxinsInfo
- Publication number
- GB1363033A GB1363033A GB4188972A GB4188972A GB1363033A GB 1363033 A GB1363033 A GB 1363033A GB 4188972 A GB4188972 A GB 4188972A GB 4188972 A GB4188972 A GB 4188972A GB 1363033 A GB1363033 A GB 1363033A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- fluorodigoxin
- compounds
- together represent
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000005907 ketalization reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1363033 22-Fluorodigoxin derivatives DR KARL THOMAE GmbH 8 Sept 1972 [11 Sept 1971] 41889/72 Heading C2U The invention comprises compounds of formula wherein one of R 1 and R 2 is H and the other is C 1-3 alkyl; or R 1 is H and R 2 is C 1-5 aliphatic carboxylic acyl; or R 1 and R 2 together represent >C(A)(B) where A and B are each H or alkyl (at least one being alkyl), or A, B and the intervening carbon atom together represent a 5- or 6-membered alicyclic ring; or R 1 and R 2 together represent >C(OR 3 )(R 4 ) where R 3 is alkyl and R 4 is H or a C 1-4 alkyl group. Compounds (I) are prepared from 22-fluorodigoxin by alkylation, acetalization, ketalization, esterification or orthoesterification. Preferably, the 3<SP>111</SP>-monoesters are prepared via the 3<SP>111</SP>,4<SP>111</SP>-orthoesters. 22-Fluorodigoxin is prepared as described in Specification 1,320,361. Compounds (I), with the exception of those wherein R 1 and R 2 represent >C(OR 3 )(R 4 ), are said to be cardioactive, and may be made up with carriers into pharmaceutical compositions fororal, rectal and parenteral administration. Reference has been directed by the Comptroller to Specification 1,320,361.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2145476A DE2145476A1 (en) | 1971-09-11 | 1971-09-11 | NEW CARDENOLIDGLYCOSIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1363033A true GB1363033A (en) | 1974-08-14 |
Family
ID=5819270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4188972A Expired GB1363033A (en) | 1971-09-11 | 1972-09-08 | Derivatives of 22-fluoro-digoxins |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4834869A (en) |
| AT (2) | AT319480B (en) |
| AU (1) | AU473516B2 (en) |
| BE (1) | BE788669A (en) |
| BG (3) | BG19146A3 (en) |
| CA (1) | CA979425A (en) |
| CH (1) | CH574457A5 (en) |
| CS (1) | CS171172B2 (en) |
| DD (1) | DD99164A5 (en) |
| DE (1) | DE2145476A1 (en) |
| DK (1) | DK129345B (en) |
| ES (1) | ES406542A1 (en) |
| FI (1) | FI49425C (en) |
| FR (1) | FR2154490B1 (en) |
| GB (1) | GB1363033A (en) |
| HU (1) | HU164161B (en) |
| IL (1) | IL40328A (en) |
| NL (1) | NL7212308A (en) |
| RO (1) | RO62337A (en) |
| SU (1) | SU421185A3 (en) |
| ZA (1) | ZA726154B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112552367A (en) * | 2020-12-11 | 2021-03-26 | 郑州安图生物工程股份有限公司 | Digoxin derivative and preparation method thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5424777A (en) * | 1977-07-23 | 1979-02-24 | Yunikon Shiyoukai Kk | Soil disinfecting apparatus using warm water |
| JPS57152828A (en) * | 1981-03-16 | 1982-09-21 | Engei Gijutsu Center Kk | Cultivation in greenhouse |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG17306A3 (en) * | 1969-06-10 | 1973-07-25 | Dr. Karl Thomae Gmbh | METHOD FOR OBTAINING NEW CARDENOLIDE-GLYCOSIDES |
| RO60624A (en) * | 1970-03-05 | 1976-07-15 |
-
0
- BE BE788669D patent/BE788669A/en unknown
-
1971
- 1971-09-11 DE DE2145476A patent/DE2145476A1/en active Pending
-
1972
- 1972-08-25 JP JP47085226A patent/JPS4834869A/ja active Pending
- 1972-08-30 SU SU1824419A patent/SU421185A3/ru active
- 1972-09-06 CH CH1670675A patent/CH574457A5/xx not_active IP Right Cessation
- 1972-09-07 AT AT766872A patent/AT319480B/en active
- 1972-09-07 AT AT1061773*7A patent/AT329193B/en not_active IP Right Cessation
- 1972-09-08 BG BG023520A patent/BG19146A3/en unknown
- 1972-09-08 BG BG023519A patent/BG19145A3/en unknown
- 1972-09-08 CA CA151,243A patent/CA979425A/en not_active Expired
- 1972-09-08 DK DK446272AA patent/DK129345B/en unknown
- 1972-09-08 ZA ZA726154A patent/ZA726154B/en unknown
- 1972-09-08 DD DD165553A patent/DD99164A5/xx unknown
- 1972-09-08 GB GB4188972A patent/GB1363033A/en not_active Expired
- 1972-09-08 BG BG021352A patent/BG19144A3/en unknown
- 1972-09-08 FI FI722482A patent/FI49425C/en active
- 1972-09-08 IL IL40328A patent/IL40328A/en unknown
- 1972-09-09 ES ES406542A patent/ES406542A1/en not_active Expired
- 1972-09-11 NL NL7212308A patent/NL7212308A/xx unknown
- 1972-09-11 FR FR7232137A patent/FR2154490B1/fr not_active Expired
- 1972-09-11 CS CS6214A patent/CS171172B2/cs unknown
- 1972-09-11 HU HUTO887A patent/HU164161B/hu unknown
- 1972-09-11 AU AU46531/72A patent/AU473516B2/en not_active Expired
- 1972-09-11 RO RO7200072194A patent/RO62337A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112552367A (en) * | 2020-12-11 | 2021-03-26 | 郑州安图生物工程股份有限公司 | Digoxin derivative and preparation method thereof |
| CN112552367B (en) * | 2020-12-11 | 2023-06-06 | 郑州安图生物工程股份有限公司 | Digoxin derivative and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DD99164A5 (en) | 1973-07-20 |
| CS171172B2 (en) | 1976-10-29 |
| AU473516B2 (en) | 1976-06-24 |
| DK129345C (en) | 1975-02-17 |
| JPS4834869A (en) | 1973-05-22 |
| AU4653172A (en) | 1974-03-21 |
| DK129345B (en) | 1974-09-30 |
| FI49425B (en) | 1975-02-28 |
| IL40328A (en) | 1976-01-30 |
| CH574457A5 (en) | 1976-04-15 |
| SU421185A3 (en) | 1974-03-25 |
| BG19144A3 (en) | 1975-04-30 |
| AT319480B (en) | 1974-12-27 |
| HU164161B (en) | 1973-12-28 |
| BG19145A3 (en) | 1975-04-30 |
| IL40328A0 (en) | 1972-11-28 |
| FR2154490B1 (en) | 1975-10-31 |
| ATA1061773A (en) | 1975-07-15 |
| ZA726154B (en) | 1974-05-29 |
| AT329193B (en) | 1976-04-26 |
| FR2154490A1 (en) | 1973-05-11 |
| FI49425C (en) | 1975-06-10 |
| CA979425A (en) | 1975-12-09 |
| RO62337A (en) | 1977-10-15 |
| BE788669A (en) | 1973-03-12 |
| NL7212308A (en) | 1973-03-13 |
| DE2145476A1 (en) | 1973-03-22 |
| ES406542A1 (en) | 1975-09-16 |
| BG19146A3 (en) | 1975-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |