GB1360056A - Processes for the preparation of derivatives of indolylacetic acid - Google Patents
Processes for the preparation of derivatives of indolylacetic acidInfo
- Publication number
- GB1360056A GB1360056A GB3357371A GB3357371A GB1360056A GB 1360056 A GB1360056 A GB 1360056A GB 3357371 A GB3357371 A GB 3357371A GB 3357371 A GB3357371 A GB 3357371A GB 1360056 A GB1360056 A GB 1360056A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- formula
- derivatives
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QOPBEBWGSGFROG-UHFFFAOYSA-N 2-(1h-indol-2-yl)acetic acid Chemical class C1=CC=C2NC(CC(=O)O)=CC2=C1 QOPBEBWGSGFROG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019439 ethyl acetate Nutrition 0.000 abstract 1
- 125000000623 heterocyclic group Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1360056 1 - Heterocyclylcarbonylindole - 3- acetic acids and esters CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT 16 July 1971 [31 July 1970] 33573/71 Heading C2C Compounds of formula (wherein R halogen- or nitro-substituted heterocyclyl containing ring O, S and/or N; R<SP>1</SP>, R<SP>2</SP> are each H or alkyl ; and R<SP>3</SP> is H, alkyl or alkoxy) are prepared by (a) reacting a compound p-R<SP>3</SP>C 6 H 4 N(R<SP>5</SP>)COR(II), where R<SP>5</SP> is amino, alkylideneamino or NHSO 3 H, with provided that when II is an N-acylhydrazine or -hydrazone (i.e. R<SP>5</SP> # NHSO 3 H) it is prepared by acylation, or (b) cyclizing a compound of formula Therapeutic compositions comprise the compounds of the given formula (prepared as described above), which have anti-inflammatory analgesic, anti-pyretic and anti-arteriosclerotic activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3357371A GB1360056A (en) | 1971-07-16 | 1971-07-16 | Processes for the preparation of derivatives of indolylacetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3357371A GB1360056A (en) | 1971-07-16 | 1971-07-16 | Processes for the preparation of derivatives of indolylacetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1360056A true GB1360056A (en) | 1974-07-17 |
Family
ID=10354695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3357371A Expired GB1360056A (en) | 1971-07-16 | 1971-07-16 | Processes for the preparation of derivatives of indolylacetic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1360056A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115055141A (en) * | 2022-08-01 | 2022-09-16 | 常州大学 | Device for synthesizing indole acetic acid based on air and preparation method of indole acetic acid |
-
1971
- 1971-07-16 GB GB3357371A patent/GB1360056A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115055141A (en) * | 2022-08-01 | 2022-09-16 | 常州大学 | Device for synthesizing indole acetic acid based on air and preparation method of indole acetic acid |
| CN115055141B (en) * | 2022-08-01 | 2024-03-15 | 常州大学 | Device for synthesizing indoleacetic acid based on air and preparation method of indoleacetic acid |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
| PCNP | Patent ceased through non-payment of renewal fee |