GB1359198A - Ocular insert - Google Patents
Ocular insertInfo
- Publication number
- GB1359198A GB1359198A GB3779271A GB3779271A GB1359198A GB 1359198 A GB1359198 A GB 1359198A GB 3779271 A GB3779271 A GB 3779271A GB 3779271 A GB3779271 A GB 3779271A GB 1359198 A GB1359198 A GB 1359198A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mantle
- crosslinked
- nylon
- drug
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 239000004677 Nylon Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229920001778 nylon Polymers 0.000 abstract 2
- -1 polyethylene terephthalate Polymers 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 210000005252 bulbus oculi Anatomy 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 239000000850 decongestant Substances 0.000 abstract 1
- 229940124581 decongestants Drugs 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 210000003717 douglas' pouch Anatomy 0.000 abstract 1
- 210000000744 eyelid Anatomy 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 229920000139 polyethylene terephthalate Polymers 0.000 abstract 1
- 239000005020 polyethylene terephthalate Substances 0.000 abstract 1
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 1
- 239000011118 polyvinyl acetate Substances 0.000 abstract 1
- 239000004800 polyvinyl chloride Substances 0.000 abstract 1
- 229920000915 polyvinyl chloride Polymers 0.000 abstract 1
- 210000003786 sclera Anatomy 0.000 abstract 1
- 229920005573 silicon-containing polymer Polymers 0.000 abstract 1
- 230000001975 sympathomimetic effect Effects 0.000 abstract 1
- 229940064707 sympathomimetics Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
1359198 Ocular implant ALZA CORP 11 Aug 1971 37792/71 Heading A5B A medicament form which can be inserted into the cul-de-sac of the conjuctiva between the sclera of the eyeball and the eyelid comprises an appropriately shaped and dimensioned flexible body composed of a polymeric material outer mantle containing a drug or drug composition which is released gradually by molecular diffusion through the mantle either as such or in solution with tear liquid which diffuses through the mantle. Suitable mantle materials are: polyvinyl chloride, nylon, soft nylon, polyethylene terephthalate and silicone polymers (to which a plasticizer may be added); hydrophilic hydrogels of acrylic and methacrylic acid esters, modified collagen, crosslinked hydrophilic polyether gels and crosslinked, partially hydrolysed polyvinyl acetate. A very wide selection of drugs are enumerated including antibiotics, antibacterials, anti-allergics, anti-inflammatory agents, decongestants, moitics and antichlorinesterases and sympathomimetics, many specific examples being given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712140557 DE2140557A1 (en) | 1971-08-13 | 1971-08-13 | MEDICINE DELIVERY TABLET FOR A HUMAN EYEBALL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1359198A true GB1359198A (en) | 1974-07-10 |
Family
ID=5816619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3779271A Expired GB1359198A (en) | 1971-08-13 | 1971-08-11 | Ocular insert |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH560051A5 (en) |
| DE (1) | DE2140557A1 (en) |
| FR (1) | FR2148959A5 (en) |
| GB (1) | GB1359198A (en) |
| NL (1) | NL7111080A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077261A3 (en) * | 1981-10-08 | 1984-03-28 | Merck & Co. Inc. | Biosoluble ocular insert |
| US4730013A (en) * | 1981-10-08 | 1988-03-08 | Merck & Co., Inc. | Biosoluble ocular insert |
| WO2001032140A1 (en) * | 1999-11-04 | 2001-05-10 | Btg Int Ltd | Ocular insert |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2439023A1 (en) * | 1978-10-16 | 1980-05-16 | Alza Corp | Drug-releasing intra=ocular device - for placement and retention in upper fornix above upper tarsal plate and canthal ligaments |
| FR2559780B1 (en) * | 1984-02-21 | 1990-05-04 | Tech Cuir Centre | IMPLANTABLE BIOCOMPATIBLE COLLAGEN-BASED SYSTEMS FOR CELL STORAGE AND / OR CULTURE AND / OR CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
-
1971
- 1971-08-11 GB GB3779271A patent/GB1359198A/en not_active Expired
- 1971-08-11 NL NL7111080A patent/NL7111080A/xx unknown
- 1971-08-11 FR FR7129368A patent/FR2148959A5/fr not_active Expired
- 1971-08-12 CH CH1198171A patent/CH560051A5/xx not_active IP Right Cessation
- 1971-08-13 DE DE19712140557 patent/DE2140557A1/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077261A3 (en) * | 1981-10-08 | 1984-03-28 | Merck & Co. Inc. | Biosoluble ocular insert |
| US4730013A (en) * | 1981-10-08 | 1988-03-08 | Merck & Co., Inc. | Biosoluble ocular insert |
| WO2001032140A1 (en) * | 1999-11-04 | 2001-05-10 | Btg Int Ltd | Ocular insert |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2148959A5 (en) | 1973-03-23 |
| CH560051A5 (en) | 1975-03-27 |
| NL7111080A (en) | 1973-02-13 |
| DE2140557A1 (en) | 1973-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |