GB1356789A - Derivatives of theophylline - Google Patents
Derivatives of theophyllineInfo
- Publication number
- GB1356789A GB1356789A GB3802570A GB3802570A GB1356789A GB 1356789 A GB1356789 A GB 1356789A GB 3802570 A GB3802570 A GB 3802570A GB 3802570 A GB3802570 A GB 3802570A GB 1356789 A GB1356789 A GB 1356789A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- theophylline
- pyridine
- reacting
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical class O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 5
- -1 pyridine-carbonyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 2
- 229960000278 theophylline Drugs 0.000 abstract 2
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 230000003555 analeptic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000916 dilatatory effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000003212 lipotrophic effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1356789 Theophylline derivatives SPASOC PRODOTTI ANTIBIOTICI SpA 3 Aug 1971 [6 Aug 1970] 38025/70 Addition to 1230663 Heading C2C Novel theophylline derivatives of the general Formula (II) wherein R 1 is H, or pyridine-carbonyl, R 2 is H, pyridine-carbonyl, pyridine-carbonyloxy or alkylol, at least one of R 1 and R 2 being other than H, and R 3 is alkyl, and the acid addition and quaternary ammonium compounds thereof, may be obtained (a) by reacting a compound of Formula (IV) wherein R 4 is H or an alkylol radical, with a pyridine carboxylic acid or its reactive derivative, (b) by reaction of theophylline with a compound of the formula in which " halogen " is Br, Cl or I, in the presence of an inert solvent, or (c) by reacting a 7- (#-halohydroxyalkyl)-theophylline of the Formula (VI) in which halogen is Cl, Br or I, with an amine R 2 NHR 3 , in the presence of an inert solvent; and optionally reacting the product with an organic or inorganic acid to form the acid addition salt, or with a quaternizing agent to form the quaternary ammonium compound. Pharmaceutical compositions having diuretic, bronchiolar dilating, myocardial stimulating, smooth muscle relaxing, lipotropic, analeptic and vasodilating activity comprise compounds of Formula (II) above in admixture with a liquid or solid pharmaceutical diluent or carrier, in forms suitably for administration orally, intramuscularly, intravenously or rectally.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3802570A GB1356789A (en) | 1970-08-06 | 1970-08-06 | Derivatives of theophylline |
| BE771009A BE771009R (en) | 1970-08-06 | 1971-08-05 | DERIVATIVES OF |
| ES393934A ES393934A2 (en) | 1970-08-06 | 1971-08-05 | Derivatives of theophylline |
| FR7128797A FR2102082B2 (en) | 1970-08-06 | 1971-08-05 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3802570A GB1356789A (en) | 1970-08-06 | 1970-08-06 | Derivatives of theophylline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1356789A true GB1356789A (en) | 1974-06-12 |
Family
ID=10400674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3802570A Expired GB1356789A (en) | 1970-08-06 | 1970-08-06 | Derivatives of theophylline |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE771009R (en) |
| ES (1) | ES393934A2 (en) |
| FR (1) | FR2102082B2 (en) |
| GB (1) | GB1356789A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US5801181A (en) * | 1993-03-31 | 1998-09-01 | Cell Therapeutics, Inc. | Amino alcohol substituted cyclic compounds |
| US11426412B2 (en) | 2017-10-18 | 2022-08-30 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| US11459338B2 (en) | 2017-11-24 | 2022-10-04 | Jubilant Episcribe Llc | Heterocyclic compounds as PRMT5 inhibitors |
| US11529341B2 (en) | 2018-03-13 | 2022-12-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| US11833156B2 (en) | 2017-09-22 | 2023-12-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1230663A (en) * | 1968-12-10 | 1971-05-05 |
-
1970
- 1970-08-06 GB GB3802570A patent/GB1356789A/en not_active Expired
-
1971
- 1971-08-05 FR FR7128797A patent/FR2102082B2/fr not_active Expired
- 1971-08-05 ES ES393934A patent/ES393934A2/en not_active Expired
- 1971-08-05 BE BE771009A patent/BE771009R/en active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750575A (en) * | 1993-03-31 | 1998-05-12 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US5777117A (en) * | 1993-03-31 | 1998-07-07 | Cell Therapeutics, Inc. | Method for preparing substituted amino alcohol compounds |
| US5801181A (en) * | 1993-03-31 | 1998-09-01 | Cell Therapeutics, Inc. | Amino alcohol substituted cyclic compounds |
| US5824677A (en) * | 1993-03-31 | 1998-10-20 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US5837703A (en) * | 1993-03-31 | 1998-11-17 | Cell Therapeutics, Inc. | Amino-alcohol substituted cyclic compounds |
| US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US11833156B2 (en) | 2017-09-22 | 2023-12-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| US12357639B2 (en) | 2017-09-22 | 2025-07-15 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| US11426412B2 (en) | 2017-10-18 | 2022-08-30 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| US11459338B2 (en) | 2017-11-24 | 2022-10-04 | Jubilant Episcribe Llc | Heterocyclic compounds as PRMT5 inhibitors |
| US11529341B2 (en) | 2018-03-13 | 2022-12-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2102082A2 (en) | 1972-04-07 |
| BE771009R (en) | 1971-12-16 |
| ES393934A2 (en) | 1974-02-16 |
| FR2102082B2 (en) | 1974-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |