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GB1345640A - Piperazinyl pyrimidines - Google Patents

Piperazinyl pyrimidines

Info

Publication number
GB1345640A
GB1345640A GB442172A GB442172A GB1345640A GB 1345640 A GB1345640 A GB 1345640A GB 442172 A GB442172 A GB 442172A GB 442172 A GB442172 A GB 442172A GB 1345640 A GB1345640 A GB 1345640A
Authority
GB
United Kingdom
Prior art keywords
pyrimidines
chloro
moieties
dichloro
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB442172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHELL INT RESEARCH
Shell Internationale Research Maatschappij BV
Original Assignee
SHELL INT RESEARCH
Shell Internationale Research Maatschappij BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHELL INT RESEARCH, Shell Internationale Research Maatschappij BV filed Critical SHELL INT RESEARCH
Publication of GB1345640A publication Critical patent/GB1345640A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1345640 Pyrimidines SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ NV 31 Jan 1972 [1 Feb 1971] 4421/72 Heading C2C Novel compounds of Formula I wherein R represents morpholine, monoalkylamine of up to 6 carbon atoms or cycloalkylamine of up to 6 carbon atoms; R<SP>1</SP> is any of the moieties represented by R or is piperazine; or their acid addition salts and hydrates are prepared by a selected stepwise replacement of the chlorine moieties of 2,4,6-trichloropyrimidine with the 2- and 4-chloro substituents being replaced first by the selected amino moieties as defined by R and R<SP>1</SP> above and then the 6-chloro substituent then being replaced by a piperazino moiety. Intermediate 6 - chloro - R - R<SP>1</SP> - pyrimidines, 2,6-dichloro - 4 - R - pyrimidines, and 4,6-dichloro-R-pyrimidines are isolated. Pharmaceutical compositions in conventional forms for oral, rectal and parenteral administration and having anti-inflammatory activity comprise an above novel compound and a suitable adjuvant.
GB442172A 1971-02-01 1972-01-31 Piperazinyl pyrimidines Expired GB1345640A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11163571A 1971-02-01 1971-02-01

Publications (1)

Publication Number Publication Date
GB1345640A true GB1345640A (en) 1974-01-30

Family

ID=22339605

Family Applications (1)

Application Number Title Priority Date Filing Date
GB442172A Expired GB1345640A (en) 1971-02-01 1972-01-31 Piperazinyl pyrimidines

Country Status (1)

Country Link
GB (1) GB1345640A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A3 (en) * 1985-09-12 1987-07-16 Upjohn Co C20 through c26 amino steroids
AU614661B2 (en) * 1985-09-12 1991-09-05 Pharmacia & Upjohn Company Amines useful in the preparation of c20 through c26 amine steroids
US5380840A (en) * 1985-09-12 1995-01-10 The Upjohn Company Triazinylpiperazinyl steroids
US5550240A (en) * 1992-06-09 1996-08-27 Richter Gedeon Vegyeszeti Gyar Rt. Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same
JP2009543765A (en) * 2006-07-14 2009-12-10 ノバルティス アクチエンゲゼルシャフト Pyrimidine derivatives as ALK-5 inhibitors
US20100298143A1 (en) * 2009-05-19 2010-11-25 Dow Agrosciences Llc Compounds and methods for controlling fungi

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A3 (en) * 1985-09-12 1987-07-16 Upjohn Co C20 through c26 amino steroids
AU614661B2 (en) * 1985-09-12 1991-09-05 Pharmacia & Upjohn Company Amines useful in the preparation of c20 through c26 amine steroids
US5380840A (en) * 1985-09-12 1995-01-10 The Upjohn Company Triazinylpiperazinyl steroids
US5380841A (en) * 1985-09-12 1995-01-10 The Upjohn Company Pyridinylpiperazinyl steroids
US5380839A (en) * 1985-09-12 1995-01-10 The Upjohn Company Phenylpiperazinyl steroids
US5382661A (en) * 1985-09-12 1995-01-17 The Upjohn Company Pyrazinylpiperazinyl steroids
US5506354A (en) * 1985-09-12 1996-04-09 The Upjohn Company Imidazolylpiperazinyl steroids
US5550240A (en) * 1992-06-09 1996-08-27 Richter Gedeon Vegyeszeti Gyar Rt. Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same
JP2009543765A (en) * 2006-07-14 2009-12-10 ノバルティス アクチエンゲゼルシャフト Pyrimidine derivatives as ALK-5 inhibitors
US20100298143A1 (en) * 2009-05-19 2010-11-25 Dow Agrosciences Llc Compounds and methods for controlling fungi
JP2012527461A (en) * 2009-05-19 2012-11-08 ダウ アグロサイエンシィズ エルエルシー Compounds and methods for controlling fungi
US8759356B2 (en) * 2009-05-19 2014-06-24 Dow Agrosciences, Llc. Compounds and methods for controlling fungi
AU2010250017B2 (en) * 2009-05-19 2015-02-12 Dow Agrosciences Llc Compounds and methods for controlling fungi

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee