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GB1235022A - A new method for the production of cyclophosphamide - Google Patents

A new method for the production of cyclophosphamide

Info

Publication number
GB1235022A
GB1235022A GB2818869A GB2818869A GB1235022A GB 1235022 A GB1235022 A GB 1235022A GB 2818869 A GB2818869 A GB 2818869A GB 2818869 A GB2818869 A GB 2818869A GB 1235022 A GB1235022 A GB 1235022A
Authority
GB
United Kingdom
Prior art keywords
cyclophosphamide
formula
production
new method
mole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2818869A
Inventor
Wolfram Hirsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAEAEKE AG
Original Assignee
LAEAEKE AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAEAEKE AG filed Critical LAEAEKE AG
Priority to GB2818869A priority Critical patent/GB1235022A/en
Publication of GB1235022A publication Critical patent/GB1235022A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)

Abstract

1,235,022. Preparing cyclophosphamide. LAAKE OY. 4 June, 1969, No. 28188/69. Heading C2C. Cyclophosphamide of the formula is obtained by reacting one mole of a compound of the formula with one mole of a compound of the formula in an inert solvent, e.g. methylene chloride, in the presence of substantially 2 moles of triethylamine as acid binding agent, removing the formed triethylamine hydrochloride and the solvent and then adding an excess of water to form the monohydrate.
GB2818869A 1969-06-04 1969-06-04 A new method for the production of cyclophosphamide Expired GB1235022A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2818869A GB1235022A (en) 1969-06-04 1969-06-04 A new method for the production of cyclophosphamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2818869A GB1235022A (en) 1969-06-04 1969-06-04 A new method for the production of cyclophosphamide

Publications (1)

Publication Number Publication Date
GB1235022A true GB1235022A (en) 1971-06-09

Family

ID=10271686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2818869A Expired GB1235022A (en) 1969-06-04 1969-06-04 A new method for the production of cyclophosphamide

Country Status (1)

Country Link
GB (1) GB1235022A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2427339A1 (en) * 1978-05-29 1979-12-28 Otsuka Pharma Co Ltd NEW OPTICALLY ACTIVE DERIVATIVES OF OXAZAPHOSPHORINE AND THEIR PREPARATION PROCESS
US6187941B1 (en) * 1997-09-06 2001-02-13 Asta Medica Aktiengesellschaft Process for the preparation of oxazaphosphorine-2-amines
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2013051994A1 (en) 2011-10-03 2013-04-11 Moreinx Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
WO2016156927A1 (en) 2015-04-02 2016-10-06 PRZEDSIĘBIORSTWO PRODUKCYJNO-WDROŻENIOWE IFOTAM Sp. z o.o. Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide
CN107501327A (en) * 2017-07-20 2017-12-22 暨明医药科技（苏州）有限公司 The method for crystallising of endoxan-water thing
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2427339A1 (en) * 1978-05-29 1979-12-28 Otsuka Pharma Co Ltd NEW OPTICALLY ACTIVE DERIVATIVES OF OXAZAPHOSPHORINE AND THEIR PREPARATION PROCESS
US4239709A (en) * 1978-05-29 1980-12-16 Otsuka Pharmaceutical Co., Ltd. Process for preparing optically active oxazaphosphorins
US6187941B1 (en) * 1997-09-06 2001-02-13 Asta Medica Aktiengesellschaft Process for the preparation of oxazaphosphorine-2-amines
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP3311827A1 (en) 2011-10-03 2018-04-25 Moreinx AB Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
WO2013051994A1 (en) 2011-10-03 2013-04-11 Moreinx Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
EP4176871A1 (en) 2011-10-03 2023-05-10 Canqura Oncology Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
WO2016156927A1 (en) 2015-04-02 2016-10-06 PRZEDSIĘBIORSTWO PRODUKCYJNO-WDROŻENIOWE IFOTAM Sp. z o.o. Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide
CN107501327A (en) * 2017-07-20 2017-12-22 暨明医药科技（苏州）有限公司 The method for crystallising of endoxan-water thing
CN107501327B (en) * 2017-07-20 2019-07-05 暨明医药科技（苏州）有限公司 Cyclophosphamide-water object method for crystallising
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect
WO2020127115A1 (en) 2018-12-18 2020-06-25 Croda International Plc Filamentous nanoparticles having vaccine adjuvant effect
US12268740B2 (en) 2018-12-18 2025-04-08 Croda International Plc Filamentous nanoparticles having vaccine adjuvant effect

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