GB1222294A - Oxazinobenzodiazepine derivatives - Google Patents
Oxazinobenzodiazepine derivativesInfo
- Publication number
- GB1222294A GB1222294A GB41548/69A GB4154869A GB1222294A GB 1222294 A GB1222294 A GB 1222294A GB 41548/69 A GB41548/69 A GB 41548/69A GB 4154869 A GB4154869 A GB 4154869A GB 1222294 A GB1222294 A GB 1222294A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- oxazinobenzodiazepine
- derivatives
- formula
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AAVXHXYXRFVOQX-UHFFFAOYSA-N oxazino[3,4-i][1,2]benzodiazepine Chemical class N1=NC=CC=C2C=CC3=NOC=CC3=C21 AAVXHXYXRFVOQX-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1,222,294. Oxazinobenzodiazepine derivatives. UPJOHN CO. 20 Aug., 1969 [19 Sept., 1968; 27 March, 1969], No. 41548/69. Heading C2C. Compounds of the general formula (R 1 , 2 , 3 , a = H, C 1-6 alkyl or alkoxy, halogen, CF 3 , NO 2 , CN; R 5 = H, C 1-6 alkyl, cyclopropylmethyl, PhCH 2 ; R 6 = O, S; R, = H, C 1-6 alkyl or alkoxy; R 8 = H, C 1-6 alkyl, Ph) are prepared by reacting a compound of the formula with a compound (which may be prepared in situ) of the formula optionally followed by removal of the 8-benzyl group, if present, by hydrogenolysis. The above compounds are sedatives, tranquilizers and anticonvulsants, and may be administered in the form of pharmaceutical and veterinary preparations containing them together with a carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76096368A | 1968-09-19 | 1968-09-19 | |
| US81122469A | 1969-03-27 | 1969-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1222294A true GB1222294A (en) | 1971-02-10 |
Family
ID=27116902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41548/69A Expired GB1222294A (en) | 1968-09-19 | 1969-08-20 | Oxazinobenzodiazepine derivatives |
Country Status (13)
| Country | Link |
|---|---|
| BE (1) | BE739131A (en) |
| CH (1) | CH534176A (en) |
| DE (1) | DE1947226C3 (en) |
| DK (1) | DK140284B (en) |
| ES (1) | ES371392A1 (en) |
| FR (1) | FR2018432B1 (en) |
| GB (1) | GB1222294A (en) |
| IL (1) | IL32875A (en) |
| MY (1) | MY7400140A (en) |
| NL (1) | NL140734B (en) |
| PL (1) | PL80700B1 (en) |
| SE (1) | SE372016B (en) |
| SU (1) | SU419036A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL33190A (en) * | 1968-10-24 | 1972-11-28 | Sankyo Co | Benzodiazepine compounds and their preparation |
| DE2141440A1 (en) * | 1970-09-25 | 1972-03-30 | F Hoffmann La Roche & Co AG, Basel (Schweiz) | Benzodiazepm derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1450867A (en) * | 1964-08-07 | 1966-06-24 | Sandoz Sa | New benzo-diazepine derivatives and their preparation |
-
1969
- 1969-08-20 GB GB41548/69A patent/GB1222294A/en not_active Expired
- 1969-08-21 IL IL32875A patent/IL32875A/en unknown
- 1969-09-10 ES ES371392A patent/ES371392A1/en not_active Expired
- 1969-09-10 NL NL696913760A patent/NL140734B/en not_active IP Right Cessation
- 1969-09-15 SU SU1365675A patent/SU419036A3/en active
- 1969-09-18 FR FR696931844A patent/FR2018432B1/fr not_active Expired
- 1969-09-18 SE SE6912857A patent/SE372016B/xx unknown
- 1969-09-18 DE DE1947226A patent/DE1947226C3/en not_active Expired
- 1969-09-18 DK DK498669AA patent/DK140284B/en unknown
- 1969-09-18 PL PL1969135881A patent/PL80700B1/pl unknown
- 1969-09-19 CH CH1420569A patent/CH534176A/en not_active IP Right Cessation
- 1969-09-19 BE BE739131D patent/BE739131A/xx not_active IP Right Cessation
-
1974
- 1974-12-30 MY MY140/74A patent/MY7400140A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE739131A (en) | 1970-03-19 |
| DE1947226A1 (en) | 1970-03-26 |
| IL32875A (en) | 1972-06-28 |
| PL80700B1 (en) | 1975-08-30 |
| DE1947226C3 (en) | 1979-05-10 |
| ES371392A1 (en) | 1971-10-16 |
| CH534176A (en) | 1973-02-28 |
| SE372016B (en) | 1974-12-09 |
| DK140284C (en) | 1979-12-17 |
| MY7400140A (en) | 1974-12-31 |
| DK140284B (en) | 1979-07-23 |
| NL140734B (en) | 1974-01-15 |
| IL32875A0 (en) | 1969-11-12 |
| DE1947226B2 (en) | 1978-09-14 |
| FR2018432B1 (en) | 1973-01-12 |
| FR2018432A1 (en) | 1970-05-29 |
| NL6913760A (en) | 1970-03-23 |
| SU419036A3 (en) | 1974-03-05 |
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