GB1205019A - Improvements in or relating to oral dosage forms - Google Patents
Improvements in or relating to oral dosage formsInfo
- Publication number
- GB1205019A GB1205019A GB5487566A GB5487566A GB1205019A GB 1205019 A GB1205019 A GB 1205019A GB 5487566 A GB5487566 A GB 5487566A GB 5487566 A GB5487566 A GB 5487566A GB 1205019 A GB1205019 A GB 1205019A
- Authority
- GB
- United Kingdom
- Prior art keywords
- plasticiser
- medicament
- dosage forms
- base material
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000006186 oral dosage form Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000004014 plasticizer Substances 0.000 abstract 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- IVYOVCFCGLUEHA-UHFFFAOYSA-N 1,3-dinitrosooxypropan-2-yl nitrite Chemical compound O=NOCC(ON=O)CON=O IVYOVCFCGLUEHA-UHFFFAOYSA-N 0.000 abstract 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000008376 breath freshener Substances 0.000 abstract 1
- 229960001948 caffeine Drugs 0.000 abstract 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 229960001317 isoprenaline Drugs 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 229960002477 riboflavin Drugs 0.000 abstract 1
- 235000019192 riboflavin Nutrition 0.000 abstract 1
- 239000002151 riboflavin Substances 0.000 abstract 1
- 235000019204 saccharin Nutrition 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 229940081974 saccharin Drugs 0.000 abstract 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000021092 sugar substitutes Nutrition 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1,205,019. Oral dosage forms. STERWIN A.G. 7 Dec., 1967 [7 Dec., 1966], No. 54875/ 66. Heading A5B. A solid oral unit dosage form comprises a medicament, and 50-85% by weight of a pharmaceutically acceptable base material and 1-30% by wt of a plasticiser for said base material, the plasticiser and base material forming a mixture which is water-soluble, has a m.p. without charring or other decomposition between 35‹ and 90‹C and acts as a solvent for the medicament when in the molten state. The dosage forms may be prepared by dissolving the medicament in a melt of the base and plasticiser and allowing drops to fall through a cooling atmosphere on to a cool surface and allowing the mixture to solidify, usually yielding a form that is flat on one side and curved convexly on the other. Medicaments referred to are isoprenaline and its salts, alkaloids e.g. caffeine, glyceryl trinitrite, vitamins e.g. A, D or riboflavin, an aromatic mixture acting as a breath freshener and a sugar substitute e.g. saccharin. Suitable base materials include polyethylene glycols, and polyoxyethylene esters and ethers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5487566A GB1205019A (en) | 1966-12-07 | 1966-12-07 | Improvements in or relating to oral dosage forms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5487566A GB1205019A (en) | 1966-12-07 | 1966-12-07 | Improvements in or relating to oral dosage forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1205019A true GB1205019A (en) | 1970-09-09 |
Family
ID=10472324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5487566A Expired GB1205019A (en) | 1966-12-07 | 1966-12-07 | Improvements in or relating to oral dosage forms |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1205019A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012113564A1 (en) * | 2011-02-25 | 2012-08-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| US9180109B2 (en) | 2010-08-03 | 2015-11-10 | G. Pohl-Boskamp Gmbh & Co. Kg | Use of glyceryl trinitrate for treating traumatic edema |
| US9248099B2 (en) | 2012-05-31 | 2016-02-02 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| US10034850B2 (en) | 2013-11-29 | 2018-07-31 | G. Pohl-Boskamp Gmbh & Co. Kg | Sprayable aqueous composition comprising glyceryl trinitrate |
| US11166931B2 (en) | 2012-05-31 | 2021-11-09 | G. Pohl-Boskamp Gmbh & Co. Kg | Induction of arteriogenesis with an NO (nitric oxide) donor |
-
1966
- 1966-12-07 GB GB5487566A patent/GB1205019A/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9180109B2 (en) | 2010-08-03 | 2015-11-10 | G. Pohl-Boskamp Gmbh & Co. Kg | Use of glyceryl trinitrate for treating traumatic edema |
| US9693983B2 (en) | 2010-08-03 | 2017-07-04 | G. Pohl-Boskamp Gmbh & Co. Kg | Use of glyceryl trinitrate for treating traumatic edema |
| WO2012113564A1 (en) * | 2011-02-25 | 2012-08-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| US9101592B2 (en) | 2011-02-25 | 2015-08-11 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| AU2012219926B2 (en) * | 2011-02-25 | 2016-11-17 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| US9616023B2 (en) | 2011-02-25 | 2017-04-11 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilized granules containing glyceryl trinitrate |
| EP3354259A1 (en) * | 2011-02-25 | 2018-08-01 | G. Pohl-Boskamp GmbH & Co. KG | Stabilized granules containing glyceryl trinitrate |
| US9248099B2 (en) | 2012-05-31 | 2016-02-02 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| US9675552B2 (en) | 2012-05-31 | 2017-06-13 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| US11166931B2 (en) | 2012-05-31 | 2021-11-09 | G. Pohl-Boskamp Gmbh & Co. Kg | Induction of arteriogenesis with an NO (nitric oxide) donor |
| US10034850B2 (en) | 2013-11-29 | 2018-07-31 | G. Pohl-Boskamp Gmbh & Co. Kg | Sprayable aqueous composition comprising glyceryl trinitrate |
| US10987332B2 (en) | 2013-11-29 | 2021-04-27 | G. Pohl-Boskamp Gmbh & Co. Kg | Sprayable aqueous composition comprising glyceryl trinitrate |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |