GB1203308A - Improvements in or relating to tableting lubricants and tableting processes - Google Patents
Improvements in or relating to tableting lubricants and tableting processesInfo
- Publication number
- GB1203308A GB1203308A GB4244968A GB4244968A GB1203308A GB 1203308 A GB1203308 A GB 1203308A GB 4244968 A GB4244968 A GB 4244968A GB 4244968 A GB4244968 A GB 4244968A GB 1203308 A GB1203308 A GB 1203308A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oil
- film
- oils
- coated
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000314 lubricant Substances 0.000 title abstract 4
- 239000003921 oil Substances 0.000 abstract 6
- 239000002245 particle Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 239000010687 lubricating oil Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 238000001694 spray drying Methods 0.000 abstract 2
- 229920001817 Agar Polymers 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 108010076119 Caseins Proteins 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 241000206672 Gelidium Species 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 235000010419 agar Nutrition 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
1,203,308. Tablet manufacture. MILES LABORATORIES Inc. 6 Sept., 1968 [2 Oct., 1967 (2); 5 Oct., 1967], No. 42449/68. Heading A5B. Tablets, e.g. for pharmaceutical use, are prepared by compression, using conventional machinery, of a powdered mixture of tablet ingredients comprising, as lubricant, particles of an oil coated with an oil-insoluble, film-forming substance. Other lubricants, in particular siloxane polymers, may also be present and may be combined with the oil or present on the surface coating thereof. Suitable oils are vegetable and animal oils, mineral oils and synthetic oils, e.g. polyethylene glycols. Suitable coating materials are water-soluble gums, e.g. dextrin and starch gums, cellulose derivatives, e.g. hydroxypropyl cellulose and carboxymethyl cellulose, agar agar, gelatin, albumin, casein, alginates, carraghunates and synthetic film-formers e.g. polyvinyl pyrrolidone. The coated particles may be prepared by spray drying an emulsion of the oil in an aqueous solution of the film-former. The invention further comprises a tableting lubricant which comprises particles of a lubricating oil as exemplified above, coated with an oil-insoluble, film-forming substance, e.g. a gum, the lubricating oil having suspended therein a siloxane polymer having a viscosity between 240 and 11900 cps of the general formula: where R represents H or an alkyl, aryl or aralkyl group and R' represents an alkyl, aryl or aralkyl group. Such materials may also be made by spray-drying an emulsion of the oil phase in an aqueous dispersion of the filmforming substance.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67194867A | 1967-10-02 | 1967-10-02 | |
| US67200467A | 1967-10-02 | 1967-10-02 | |
| US67297867A | 1967-10-05 | 1967-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1203308A true GB1203308A (en) | 1970-08-26 |
Family
ID=27418239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4244968A Expired GB1203308A (en) | 1967-10-02 | 1968-09-06 | Improvements in or relating to tableting lubricants and tableting processes |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1800727A1 (en) |
| FR (1) | FR1589174A (en) |
| GB (1) | GB1203308A (en) |
| IT (1) | IT941516B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002041862A1 (en) * | 2000-11-21 | 2002-05-30 | Orix As | An oral hygiene preparation for inhibiting halitosis |
| WO2013192409A3 (en) * | 2012-06-20 | 2014-02-20 | Mishra Munmaya K | Silicone smokeless tobacco product |
| CN106619129A (en) * | 2017-01-22 | 2017-05-10 | 扬州大学 | Processing device and method of oral instant tablets |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594789B2 (en) * | 1986-07-18 | 1990-03-15 | Minnesota Mining And Manufacturing Company | Cosmetic compositions containing polymer-thickened oil microcapsules |
| DE68911501T2 (en) * | 1989-01-12 | 1994-03-31 | Bayer Ag | Analgesic antacid shower composition with reduced sodium content. |
-
1968
- 1968-09-06 GB GB4244968A patent/GB1203308A/en not_active Expired
- 1968-09-23 FR FR1589174D patent/FR1589174A/fr not_active Expired
- 1968-09-23 IT IT3997168A patent/IT941516B/en active
- 1968-10-02 DE DE19681800727 patent/DE1800727A1/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002041862A1 (en) * | 2000-11-21 | 2002-05-30 | Orix As | An oral hygiene preparation for inhibiting halitosis |
| WO2013192409A3 (en) * | 2012-06-20 | 2014-02-20 | Mishra Munmaya K | Silicone smokeless tobacco product |
| US11576423B2 (en) | 2012-06-20 | 2023-02-14 | Altria Client Services Llc | Smokeless tobacco product |
| CN106619129A (en) * | 2017-01-22 | 2017-05-10 | 扬州大学 | Processing device and method of oral instant tablets |
| CN106619129B (en) * | 2017-01-22 | 2022-08-23 | 扬州大学 | Processing device and method for oral instant tablets |
Also Published As
| Publication number | Publication date |
|---|---|
| IT941516B (en) | 1973-03-10 |
| DE1800727A1 (en) | 1969-05-08 |
| FR1589174A (en) | 1970-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |