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GB1298050A - Process for the preparation of amines - Google Patents

Process for the preparation of amines

Info

Publication number
GB1298050A
GB1298050A GB2708271A GB2708271A GB1298050A GB 1298050 A GB1298050 A GB 1298050A GB 2708271 A GB2708271 A GB 2708271A GB 2708271 A GB2708271 A GB 2708271A GB 1298050 A GB1298050 A GB 1298050A
Authority
GB
United Kingdom
Prior art keywords
picrate
april
tert
phenyl
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2708271A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of GB1298050A publication Critical patent/GB1298050A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1298050 A process for preparing amines SCHERICO Ltd 19 April 1971 [17 April 1970] 27082/71 Heading C2C The invention comprises converting sulphamoyl to amino by treating a N-mono- or -disubstituted sulphonamide with at least a stoichiometric amount of sodium bis-(2-methoxyethoxy) aluminium hydride, i.e. and hydrolysing the complex obtained. The examples describe the preparation of ethylamine (as its picrate), D-desoxy-ephedrine (as its picrate), N - tert. - butyl - #,4 - dihyclroxy - 3 - hydroxymethyl-phenethylamine (I), piperidine (as its picrate), cis - 3 - methoxymethoxy - 2 - methyl - 3- phenyl-azetidine, aniline (as its hydrochloride), N- methyl - 2 - phenyl - 1,3 - dioxolan - 2 - yl - methylamine (treatment of this compound with aqueous hydrochloric acid affords N-methylaminoacetophenone) and hexamethylene diamine from the corresponding methylsulphonyl or ptoluenesulphonyl compounds; (I) is obtained from 3 - carboxy - 4 - hydroxy - α - [N - tert.- butyl-tosylamino] -acetophenone.
GB2708271A 1970-04-17 1971-04-19 Process for the preparation of amines Expired GB1298050A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2966570A 1970-04-17 1970-04-17

Publications (1)

Publication Number Publication Date
GB1298050A true GB1298050A (en) 1972-11-29

Family

ID=21850223

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2708271A Expired GB1298050A (en) 1970-04-17 1971-04-19 Process for the preparation of amines

Country Status (5)

Country Link
CH (1) CH566287A5 (en)
DE (1) DE2118286A1 (en)
FR (1) FR2099072A5 (en)
GB (1) GB1298050A (en)
NL (1) NL7105057A (en)

Also Published As

Publication number Publication date
DE2118286A1 (en) 1971-10-28
NL7105057A (en) 1971-10-19
FR2099072A5 (en) 1972-03-10
CH566287A5 (en) 1975-09-15

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees