GB1293483A - Orgotein purification process - Google Patents
Orgotein purification processInfo
- Publication number
- GB1293483A GB1293483A GB0050/71A GB105071A GB1293483A GB 1293483 A GB1293483 A GB 1293483A GB 0050/71 A GB0050/71 A GB 0050/71A GB 105071 A GB105071 A GB 105071A GB 1293483 A GB1293483 A GB 1293483A
- Authority
- GB
- United Kingdom
- Prior art keywords
- orgotein
- jan
- divalent metal
- crude
- extraneous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010070915 orgotein Proteins 0.000 title abstract 4
- 229960004534 orgotein Drugs 0.000 title abstract 4
- TUGDLVFMIQZYPA-UHFFFAOYSA-N tetracopper;tetrazinc Chemical compound [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2] TUGDLVFMIQZYPA-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000013058 crude material Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
1293483 Orgotein DIAGNOSTIC DATA Inc 8 Jan 1971 [16 Jan 1970 (2)] 1050/71 Heading C3H Pure orgotein (compact, water-soluble, non- toxic, substantially non-antigenic, anti-inflammatory protein in the form of a metal chelate with a divalent metal) has an extraneous protein content and silicon content of substantially nil and a UV absorbance (A<SP>1</SP> 280 %) of 2À30À2. Crude orgotein-containing material may be purified by conventional methods until the only remaining impurities are extraneous proteins and the latter then removed either by chromatography or by heating in buffer solution in presence of a salt of a divalent metal of ionic radius 0À6 to 1À0. The source of the crude material may be animal liver.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US349270A | 1970-01-16 | 1970-01-16 | |
| US353870A | 1970-01-16 | 1970-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1293483A true GB1293483A (en) | 1972-10-18 |
Family
ID=26671830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0050/71A Expired GB1293483A (en) | 1970-01-16 | 1971-01-08 | Orgotein purification process |
Country Status (11)
| Country | Link |
|---|---|
| JP (2) | JPS4948721B1 (en) |
| BE (1) | BE765380A (en) |
| CA (1) | CA924640A (en) |
| CH (2) | CH572942A5 (en) |
| DE (1) | DE2101866C3 (en) |
| DK (1) | DK131090B (en) |
| FR (1) | FR2081438B1 (en) |
| GB (1) | GB1293483A (en) |
| IL (1) | IL35943A (en) |
| NL (1) | NL150009B (en) |
| SE (2) | SE404488B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3763137A (en) * | 1971-12-07 | 1973-10-02 | Diagnostic Data Inc | Isolation of orgotein from red blood cells |
| JPS5712993A (en) * | 1980-06-23 | 1982-01-22 | Fujirebio Inc | Isolation of superoxide dismutase |
| DE3410159A1 (en) * | 1984-03-20 | 1985-09-26 | Alfred Dipl.-Biochem. 7400 Tübingen Gärtner | Process for obtaining Cu2Zn2superoxide dismutase from red blood cells from vertebrates |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL32097A (en) * | 1968-05-13 | 1973-08-29 | Diagnostic Data Inc | Isolation of orgotein from blood |
-
1970
- 1970-12-24 CA CA101505A patent/CA924640A/en not_active Expired
- 1970-12-31 IL IL35943A patent/IL35943A/en unknown
-
1971
- 1971-01-08 GB GB0050/71A patent/GB1293483A/en not_active Expired
- 1971-01-08 NL NL717100222A patent/NL150009B/en not_active IP Right Cessation
- 1971-01-13 FR FR7100918A patent/FR2081438B1/fr not_active Expired
- 1971-01-15 DK DK17271AA patent/DK131090B/en unknown
- 1971-01-15 CH CH66271A patent/CH572942A5/xx not_active IP Right Cessation
- 1971-01-15 SE SE7100483A patent/SE404488B/en unknown
- 1971-01-15 DE DE2101866A patent/DE2101866C3/en not_active Expired
- 1971-01-16 JP JP46001056A patent/JPS4948721B1/ja active Pending
- 1971-04-06 BE BE765380A patent/BE765380A/en not_active IP Right Cessation
-
1973
- 1973-09-24 SE SE7312972A patent/SE417277B/en unknown
-
1974
- 1974-08-09 JP JP9139874A patent/JPS5619876B2/ja not_active Expired
-
1975
- 1975-11-11 CH CH1458075A patent/CH602782A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4948721B1 (en) | 1974-12-23 |
| IL35943A0 (en) | 1971-02-25 |
| DK131090C (en) | 1975-10-27 |
| DE2101866B2 (en) | 1977-11-03 |
| DE2101866A1 (en) | 1971-07-22 |
| SE404488B (en) | 1978-10-09 |
| DE2101866C3 (en) | 1978-06-29 |
| BE765380A (en) | 1971-08-30 |
| FR2081438A1 (en) | 1971-12-03 |
| JPS5069215A (en) | 1975-06-10 |
| NL7100222A (en) | 1971-07-20 |
| SE417277B (en) | 1981-03-09 |
| CA924640A (en) | 1973-04-17 |
| JPS5619876B2 (en) | 1981-05-09 |
| IL35943A (en) | 1974-01-14 |
| DK131090B (en) | 1975-05-26 |
| CH572942A5 (en) | 1976-02-27 |
| NL150009B (en) | 1976-07-15 |
| CH602782A5 (en) | 1978-08-15 |
| FR2081438B1 (en) | 1974-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |